1-20 of 26
Keywords: EGF
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
J Cell Sci (2021) 134 (17): jcs258456.
Published: 03 September 2021
... localization compared with other markers of in vivo ERK activation. EGF EGFR LET-23 LET-60 LIN-45 MEK-2 MAPK C. elegans Nuclear translocation nKTR KTR Vulval development Cell fate patterning National Institutes of Health http://dx.doi.org/10.13039/100000002 R01GM121625...
Includes: Supplementary data
Journal Articles
In collection:
Membrane Trafficking
J Cell Sci (2021) 134 (7): jcs252411.
Published: 15 April 2021
... the recruitment of 5-inositol phosphatases to circular ruffles. Macropinocytosis GTPase Rab Phosphatase Phosphoinositide EGF Ruffling Macropinocytosis is an actin-driven process that involves the formation and extension of plasma membrane ruffles and the eventual closure of large (≥0.2 to 5.0...
Includes: Supplementary data
Journal Articles
In collection:
Membrane Trafficking
J Cell Sci (2019) 132 (19): jcs229179.
Published: 03 October 2019
... (MVBs) for degradation. The regulatory mechanism underlying formation of intralumenal vesicles en route to generation of MVBs is not fully understood. In this study, we found that SH3YL1, a phosphoinositide-binding protein, had a vesicular localization pattern overlapping with internalized EGF...
Includes: Supplementary data
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2018) 131 (10): jcs215780.
Published: 16 May 2018
... differentiate. Activation of epidermal growth factor (EGF) signaling mediated the proliferative response to matrix stiffness and depended on focal adhesion assembly and cytoskeletal tension. Comparison of normal skin with keloid scar tissue further revealed an upregulation of EGF signaling within the epidermis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (16): 2707–2721.
Published: 15 August 2017
... a differential role in sorting of the degradative cargoes. CIM6PR EGF SNX12 Endosomal maturation Intraluminal vesicles Retromer Endocytosis begins at the plasma membrane where distinct signaling events select a range of different cargoes for internalization ( Sigismund et al., 2012 ). Several...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (5): 975–988.
Published: 01 March 2017
... oxidation of a candidate upstream target, the inhibitor of κB kinase α (IKKα; encoded by CHUK ), as a mechanism of action. We show that IKKα is sulfenylated at a conserved cysteine residue in the kinase domain, which correlates with de-repression of EGF promoter activity and increased EGF expression. Thus...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (11): 2156–2168.
Published: 01 June 2015
... and EGF signaling during three-dimensional culture. Wnt3a and EGF induced the expression of the P2Y 2 receptor (P2Y 2 R, also known as P2RY2), and knockdown of P2Y 2 R suppressed tubular formation. A P2Y 2 R mutant that lacks nucleotide responsiveness rescued the phenotypes resulting from P2Y 2 R...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (5): 913–922.
Published: 01 March 2015
... acetylation sites with arginine residues prevents cytoplasmic accumulation of Net1A caused by deacetylase inhibition or EGF stimulation. By contrast, replacement of these sites with glutamine residues is sufficient for Net1A relocalization, RhoA activation and downstream signaling. Moreover, the N-terminal...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (5): 1247–1258.
Published: 01 March 2012
... directly. We show here that NGF- and EGF-induced initial cell extensions result in APC phosphorylation by the MAPK/ERK pathway, which, in parallel with inhibition of GSK-3β, promotes localization of APC to the tip of cell extensions. Whereas GSK-3β inhibition promotes APC binding and stabilization...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (2): 435–448.
Published: 15 January 2012
... signalling networks remain largely uncharacterized. Here we identify a signalling module composed of a fibronectin–α5β1-integrin–integrin-linked-kinase (ILK) complex that, in concert with epidermal growth factor (EGF) cues, cooperatively controls the formation of transient actin-based circular dorsal ruffles...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (7): 1043–1054.
Published: 01 April 2011
... by either epidermal growth factor (EGF) or NMDA. These findings support the idea that GSH might represent the most important buffer of NO toxicity in neuronal cells, and indicate that the disruption of cellular redox buffering controlled by GSH makes neuronal cells susceptible to endogenous physiological...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (23): 4156–4169.
Published: 01 December 2010
... se is critical for the peripheral recruitment of XB130. To this end we co-transfected GFP tagged XB130 with dominant negative Rac (T17A) ( Takaishi et al., 1994 ). As expected, DN-Rac completely prevented the EGF-induced formation of the F-actin belt. Instead, in the absence of Rac activity EGF...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2008) 121 (13): 2197–2207.
Published: 01 July 2008
... keratinocytes was blocked using siRNA targeting Smads. Unexpectedly, we found that EGF blocked TGFβ1-mediated N-cadherin expression in oral keratinocytes and not in OSCC cells. Mechanistically, EGF enhanced Smad phosphorylation in the linker region, and attenuated TGFβ1-mediated phosphorylation of Smad at the C...
Journal Articles
J Cell Sci (2007) 120 (19): 3465–3474.
Published: 01 October 2007
... for epidermal growth factor (EGF)-stimulated protrusion in MTLn3 carcinoma cells. When stimulated with EGF, carcinoma cells showed a rapid increase in activated Cdc42 that is primarily localized to the protruding edge of the cells. siRNA-mediated knockdown of Cdc42 expression caused a decrease in EGF-stimulated...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2007) 120 (10): 1818–1828.
Published: 15 May 2007
... is internalized from the cell surface with degradation or recycling as potential fates. However, the cellular machinery involved in cadherin internalization and recycling remains controversial. Here we investigated EGF-induced E-cadherin internalization. EGF stimulation of MCF-7 cells resulted in Rac1-modulated...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2005) 118 (12): 2707–2721.
Published: 15 June 2005
... PLP-189 of BPGAP1, with prolines 184 and 186 being indispensable for this interaction. Overexpression of EEN or BPGAP1 alone induced EGF-stimulated receptor endocytosis and ERK1/2 phosphorylation. These processes were further enhanced when EEN was present together with the wildtype...
Journal Articles
J Cell Sci (2004) 117 (15): 3221–3231.
Published: 01 July 2004
... growth factor (EGF) receptor; however, the site of action of RhoB within the endocytic pathway is still unknown. RhoB exists as two prenylated forms in cells: geranylgeranylated RhoB (RhoB-GG) and farnesylated RhoB (RhoB-F). Here we use farnesyltransferase inhibitors (FTIs) to show that prenylation...
Journal Articles
J Cell Sci (2003) 116 (23): 4799–4810.
Published: 01 December 2003
... (Dresden, Germany), respectively. GFPK44A-Dynamin II was provided by M. McNiven (Mayo Clinic, Rochester, MN). To generate YFP/CFP fusion proteins, Rab5 or Rab4 full-length cDNAs were amplified by PCR and ligated to pEYFP-C1 (Clontech) by using Bgl II and Xho I restriction sites. EGF was obtained...
Journal Articles
J Cell Sci (2003) 116 (18): 3749–3760.
Published: 15 September 2003
... in cultured keratinocytes exposed to epidermal growth factor (EGF), the signaling pathway that regulates the formation of these structures is not defined. In cultured human keratinocytes seeded on fibronectin, we found that protein-serine/threonine kinase inhibitors including staurosporine, induced...
Journal Articles
J Cell Sci (2003) 116 (17): 3543–3556.
Published: 01 September 2003
... in either a ligand bound or ligand unbound state was necessary and sufficient for EGF-induced cell migration. In a ligand bound state, β4 integrin supported EGF-induced cell migration though sustained activation of Rac1. In the absence of α6β4 integrin ligation, Rac1 activation became tempered and EGF...