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Keywords: EGF
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Journal Articles
J Cell Sci (2023) 136 (16): jcs261199.
Published: 21 August 2023
.... Published by The Company of Biologists Ltd 2023 Summary: Knockout of ErbB genes reveals that the ErbB1 and the ErbB2–ErbB3 complex mediate G1/S progression, and a ligand-independent ErbB2 activity is sufficient for preventing apoptosis at high cell density. ErbB EGF Cell proliferation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (17): jcs258456.
Published: 3 September 2021
... that all six VPCs receive the inductive signal from the epidermal growth factor (EGF) protein LIN-3. MPK-1::mKate2 is also recruited to P6.p, the presumptive primary cell, at higher levels than surrounding presumptive secondary and tertiary cells. After nuclear translocation was completed in all VPCs...
Includes: Supplementary data
Journal Articles
In collection:
Membrane trafficking
J Cell Sci (2021) 134 (7): jcs252411.
Published: 15 April 2021
... the recruitment of 5-inositol phosphatases to circular ruffles. Macropinocytosis GTPase Rab Phosphatase Phosphoinositide EGF Ruffling Canadian Institutes of Health Research http://dx.doi.org/10.13039/501100000024 FDN-143202 Heart and Stroke Foundation of Canada http...
Includes: Supplementary data
Journal Articles
In collection:
Membrane trafficking
J Cell Sci (2019) 132 (19): jcs229179.
Published: 3 October 2019
... (MVBs) for degradation. The regulatory mechanism underlying formation of intralumenal vesicles en route to generation of MVBs is not fully understood. In this study, we found that SH3YL1, a phosphoinositide-binding protein, had a vesicular localization pattern overlapping with internalized EGF...
Includes: Supplementary data
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2018) 131 (10): jcs215780.
Published: 16 May 2018
... differentiate. Activation of epidermal growth factor (EGF) signaling mediated the proliferative response to matrix stiffness and depended on focal adhesion assembly and cytoskeletal tension. Comparison of normal skin with keloid scar tissue further revealed an upregulation of EGF signaling within the epidermis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (16): 2707–2721.
Published: 15 August 2017
... role in sorting of the degradative cargoes. CIM6PR EGF SNX12 Endosomal maturation Intraluminal vesicles Retromer Endocytosis begins at the plasma membrane where distinct signaling events select a range of different cargoes for internalization ( Sigismund et al., 2012 ). Several...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (5): 975–988.
Published: 1 March 2017
... oxidation of a candidate upstream target, the inhibitor of κB kinase α (IKKα; encoded by CHUK ), as a mechanism of action. We show that IKKα is sulfenylated at a conserved cysteine residue in the kinase domain, which correlates with de-repression of EGF promoter activity and increased EGF expression. Thus...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (11): 2156–2168.
Published: 1 June 2015
... and EGF signaling during three-dimensional culture. Wnt3a and EGF induced the expression of the P2Y 2 receptor (P2Y 2 R, also known as P2RY2), and knockdown of P2Y 2 R suppressed tubular formation. A P2Y 2 R mutant that lacks nucleotide responsiveness rescued the phenotypes resulting from P2Y 2 R...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (5): 913–922.
Published: 1 March 2015
... acetylation sites with arginine residues prevents cytoplasmic accumulation of Net1A caused by deacetylase inhibition or EGF stimulation. By contrast, replacement of these sites with glutamine residues is sufficient for Net1A relocalization, RhoA activation and downstream signaling. Moreover, the N-terminal...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (5): 1247–1258.
Published: 1 March 2012
... directly. We show here that NGF- and EGF-induced initial cell extensions result in APC phosphorylation by the MAPK/ERK pathway, which, in parallel with inhibition of GSK-3β, promotes localization of APC to the tip of cell extensions. Whereas GSK-3β inhibition promotes APC binding and stabilization...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (2): 435–448.
Published: 15 January 2012
... signalling networks remain largely uncharacterized. Here we identify a signalling module composed of a fibronectin–α5β1-integrin–integrin-linked-kinase (ILK) complex that, in concert with epidermal growth factor (EGF) cues, cooperatively controls the formation of transient actin-based circular dorsal ruffles...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (7): 1043–1054.
Published: 1 April 2011
... by either epidermal growth factor (EGF) or NMDA. These findings support the idea that GSH might represent the most important buffer of NO toxicity in neuronal cells, and indicate that the disruption of cellular redox buffering controlled by GSH makes neuronal cells susceptible to endogenous physiological...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (23): 4156–4169.
Published: 1 December 2010
... and invasiveness of tumor cells. * Authors for correspondence ( [email protected] ; [email protected] ) 11 8 2010 © 2010. 2010 Actin-binding proteins AFAP1L2 Cytoskeleton EGF Dynamic remodeling of the actin cytoskeleton is indispensable for many physiological...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2008) 121 (13): 2197–2207.
Published: 1 July 2008
... keratinocytes was blocked using siRNA targeting Smads. Unexpectedly, we found that EGF blocked TGFβ1-mediated N-cadherin expression in oral keratinocytes and not in OSCC cells. Mechanistically, EGF enhanced Smad phosphorylation in the linker region, and attenuated TGFβ1-mediated phosphorylation of Smad at the C...
Journal Articles
J Cell Sci (2007) 120 (19): 3465–3474.
Published: 1 October 2007
... for epidermal growth factor (EGF)-stimulated protrusion in MTLn3 carcinoma cells. When stimulated with EGF, carcinoma cells showed a rapid increase in activated Cdc42 that is primarily localized to the protruding edge of the cells. siRNA-mediated knockdown of Cdc42 expression caused a decrease in EGF-stimulated...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2007) 120 (10): 1818–1828.
Published: 15 May 2007
... is internalized from the cell surface with degradation or recycling as potential fates. However, the cellular machinery involved in cadherin internalization and recycling remains controversial. Here we investigated EGF-induced E-cadherin internalization. EGF stimulation of MCF-7 cells resulted in Rac1-modulated...
Includes: Multimedia, Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2004) 117 (15): 3221–3231.
Published: 1 July 2004
... growth factor (EGF) receptor; however, the site of action of RhoB within the endocytic pathway is still unknown. RhoB exists as two prenylated forms in cells: geranylgeranylated RhoB (RhoB-GG) and farnesylated RhoB (RhoB-F). Here we use farnesyltransferase inhibitors (FTIs) to show that prenylation...
Journal Articles
Journal Articles
J Cell Sci (2003) 116 (18): 3749–3760.
Published: 15 September 2003
... in cultured keratinocytes exposed to epidermal growth factor (EGF), the signaling pathway that regulates the formation of these structures is not defined. In cultured human keratinocytes seeded on fibronectin, we found that protein-serine/threonine kinase inhibitors including staurosporine, induced...