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Keywords: E-cadherin
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Journal Articles
In collection:
Mechanobiology
J Cell Sci (2018) 131 (24): jcs216648.
Published: 14 December 2018
...Hannah Campbell; Christy Heidema; Daisy G. Pilarczyk; Kris A. DeMali ABSTRACT The response of cells to mechanical inputs is a key determinant of cell behavior. In response to external forces, E-cadherin initiates signal transduction cascades that allow the cell to modulate its contractility to...
Includes: Supplementary data
Journal Articles
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Cell Migration
J Cell Sci (2018) 131 (17): jcs213595.
Published: 03 September 2018
... epithelial characteristics necessary for tissue repair through regulating cytoskeleton and E-Cadherin dynamics. * Author for correspondence ( antonio.jacinto@nms.unl.pt ) Competing interests The authors declare no competing or financial interests. 5 12 2017 6 8 2018 © 2018...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2017) 130 (23): 4013–4027.
Published: 01 December 2017
... spectrometry, the MT2-MMP cytosolic tail was found to interact with the zonula occludens protein-1 (ZO-1) at the apical junctions of polarized epithelial cells. Functionally, MT2-MMP localizes in the apical domain of epithelial cells where it cleaves E-cadherin and promotes epithelial cell accumulation, a...
Includes: Supplementary data
Journal Articles
In collection:
Polarity
J Cell Sci (2017) 130 (7): 1224–1231.
Published: 01 April 2017
...-adhesion phenotype was rescued by interfering with polarity establishment, indicating that polarity establishment enforces plasma membrane compartmentalization. Consistent with this idea, the decreased plasma membrane levels of the adhesion proteins E-cadherin and MAGI-1 in ribo-1(RNAi) embryos were...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2016) 129 (12): 2416–2429.
Published: 15 June 2016
...Robert Sroka; Johan Van Lint; Sarah-Fee Katz; Marlon R. Schneider; Alexander Kleger; Stephan Paschke; Thomas Seufferlein; Tim Eiseler ABSTRACT Dynamic regulation of cell–cell adhesion by the coordinated formation and dissolution of E-cadherin-based adherens junctions is crucial for tissue...
Includes: Supplementary data
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2016) 129 (9): 1843–1854.
Published: 01 May 2016
...Ismaeel Muhamed; Jun Wu; Poonam Sehgal; Xinyu Kong; Arash Tajik; Ning Wang; Deborah E. Leckband ABSTRACT This report elucidates an E-cadherin-based force-transduction pathway that triggers changes in cell mechanics through a mechanism requiring epidermal growth factor receptor (EGFR...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (2): 354–366.
Published: 15 January 2016
... for the conserved fibroblast growth factor (FGF) signaling pathway in the maintenance of epithelial cell adhesion through FGF modulation of zygotic E-cadherin. During Drosophila gastrulation, primordial germ cells (PGCs) are transported with the posterior midgut while it undergoes dynamic cell shape...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (21): 3898–3909.
Published: 01 November 2015
... activation of SH2 domain-containing phosphatase-2 (SHP2; also known as PTPN11), a proto-oncogene. In lung and pancreatic cancer cell lines, reductions in E-cadherin expression, increases in vimentin expression and increases in cell scatter rates were larger when cells were treated with TGFβ and EGF versus...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (11): 2047–2056.
Published: 01 June 2015
... adherens junctions in Madin–Darby canine kidney (MDCK) cells. Knockdown of FilGAP by siRNA stimulated the disassembly and migration of MDCK cells induced by hepatocyte growth factor (HGF). By contrast, forced expression of FilGAP induced accumulation of E-cadherin at adherens junctions. Endogenous FilGAP...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (5): 1011–1022.
Published: 01 March 2015
.... 22 08 2014 8 12 2014 © 2015. Published by The Company of Biologists Ltd 2015 Serine threonine kinase 11 STK11 Epithelial polarity Cell extrusion E-cadherin Preimplantation Polarity formation is an important step in the development of the embryonic and extraembryonic...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (3): 499–515.
Published: 01 February 2015
... escaper flies show enhanced wing polarization defects and females exhibit strong egg chamber encapsulation defects. Live-imaging analysis suggests that the observed phenotypes are caused by an impaired turnover of E-cadherin at the membrane. Simultaneous knockdown of Cip4 and Nostrin strongly increases...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (18): 4037–4051.
Published: 15 September 2014
... fates. In assessing potential upstream inputs to this new p120-catenin–REST–CoREST pathway, REST gene targets were found to respond to the level of E-cadherin, with evidence suggesting that p120-catenin transduces signals between E-cadherin and the nucleus. In summary, we provide the first evidence for...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (15): 3331–3346.
Published: 01 August 2014
... tumorigenesis. E-cadherin (E-cad), the main component of adherens junctions, has been shown to be essential for epithelial cell extrusion, but its mechanistic contribution remains unclear. Here, we provide clear evidence that cell extrusion can be driven by the cleavage of E-cad, both in a wild-type and an...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (11): 2420–2432.
Published: 01 June 2014
... RPTPα (human gene name PTPRA ) is recruited to epithelial adherens junctions at the time of cell–cell contact, where it is in molecular proximity to E-cadherin. RPTPα is required for appropriate cadherin-dependent adhesion and for cyst architecture in three-dimensional culture. Loss of RPTPα impairs...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (10): 2189–2203.
Published: 15 May 2014
... required for cellular processes. Several C-terminal splice variants of PIPKIγ (also known as PIP5K1C) exist, and have been implicated in a multitude of cellular roles. PI(4,5)P 2 serves as a fundamental regulator of E-cadherin transport, and PI(4,5)P 2 -generating enzymes are important signaling relays in...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (10): 2326–2338.
Published: 15 May 2014
... levels of E-cadherin and β-catenin but increases those of vimentin and Twist1. Second, the motility of CPEB1-depleted cells is increased. Third, CID-9 cells normally form growth-arrested, polarized and three-dimensional acini upon culture in extracellular matrix, but CPEB1-deficient CID-9 cells form...
Journal Articles
J Cell Sci (2014) 127 (4): 885–895.
Published: 15 February 2014
...Christina M. Van Itallie; Amber Jean Tietgens; Angel Aponte; Karin Fredriksson; Alan S. Fanning; Marjan Gucek; James M. Anderson ABSTRACT Known proteins associated with the cell-adhesion protein E-cadherin include catenins and proteins involved in signaling, trafficking and actin organization...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (18): 4108–4110.
Published: 15 September 2013
... increases in junctional E-cadherin in tumor cells, upregulation of genes encoding components of cell–cell junctions, and downregulation of mesenchymal-specific and metalloproteinase-encoding genes. These data show that collagen organization, rather than density alone, is a key contributor to the invasive...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (20): 4853–4864.
Published: 15 October 2012
... was upregulated by HGF in two independent epithelial cell types, HepG2 and MDCK, whereas KLF4 knockdown inhibited HGF-induced E-cadherin suppression and cell scattering. Moreover, enforced nuclear KLF4 expression alone was sufficient to upregulate KLF4, downregulate E-cadherin and trigger scattering...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (11): 2615–2625.
Published: 01 June 2012
...Fei Geng; Weijia Zhu; Richard A. Anderson; Brian Leber; David W. Andrews E-cadherin is synthesized as a precursor and then undergoes cleavage by proprotein convertases. This processing is essential for E-cadherin maturation and cell adhesion. Loss of cell adhesion causes detachment-induced...
Includes: Supplementary data