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Keywords: Dyrk1A
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Journal Articles
Journal Articles
J Cell Sci (2012) 125 (1): 67–80.
Published: 1 January 2012
... and tyrosine phosphorylation. Here, we report on a novel regulatory mechanism; we demonstrate that N-WASP interacts with dual-specificity tyrosine-phosphorylation-regulated kinase 1A (Dyrk1A). In vitro kinase assays indicate that Dyrk1A directly phosphorylates the GTPase-binding domain (GBD) of N-WASP at three...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2009) 122 (10): 1574–1583.
Published: 15 May 2009
... effects produced on both development and health by small variations in the strength of the Notch signal. The Down-syndrome-associated kinase DYRK1A is coexpressed with Notch in various tissues during embryonic development. Here we show that DYRK1A moves to the nuclear transcription compartment where...
Includes: Supplementary data
Journal Articles
J Cell Sci (2003) 116 (15): 3099–3107.
Published: 1 August 2003
...Mónica Álvarez; Xavier Estivill; Susana de la Luna The protein kinase DYRK1A is distributed throughout the nucleoplasm,accumulating in speckle-like regions. We have found that this punctuated nuclear distribution is determined by the contribution of several elements. Although the nuclear import...