...-sensing mechanism wherein reductions in microtubule motor levels would be expected to accelerate neuronal growth, and validated this prediction in dynein heavy chain 1 Loa mutant ( Dync1h1 Loa ) sensory neurons. Here, we describe a new mouse model with a conditional deletion allele of exons 24 and 25...

... of Biologists 1998 Outer dynein arm Dynein heavy chain In vitro motility assay Flagellar dyneins are molecular motors that produce a sliding force between adjacent outer doublet microtubules (reviewed by Gibbons, 1981 ; Porter and Johnson, 1989 ; Mitchell, 1994 ). Dyneins contain heavy...

... divergent from the sea urchin beta chain (64% and 65% similarity, respectively), whereas the Chlamydomonas gamma chain is more divergent from urchin beta (54% similarity). The four glycine-rich loops identified as potential nucleotide-binding sites in other dynein heavy chains are also present...