... observed in either pacsin 2 RNAi ( Figs 3 , 8 ) or dynamin 2 RNAi cells ( Figs S1, S7 ) suggest their key roles in distinct cell adhesion machinery required for coordinated movement of collectively migrating cells. BAR domain proteins have been implicated in cancer metastasis by controlling cell...

... of CME. Structure prediction together with quantitative cellular and biochemical studies present a unique BAR domain and PI(4,5)P 2 -dependent protein–membrane interactions. Functional characterization yields accumulation of ArhGEF37 at dynamin 2-rich late endocytic sites and increased endocytosis rates...

...Hong Cao; Jing Chen; Muyiwa Awoniyi; John R. Henley; Mark A. McNiven It is well-known that dynamin 2 (Dyn2) participates in clathrin- and caveolae-mediated endocytosis; however, the role of Dyn2 in coat-independent endocytic processes remains controversial. Here we demonstrate a role for specific...