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Keywords: Dynactin
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Journal Articles
J Cell Sci (2023) 136 (5): jcs259689.
Published: 16 November 2022
... , A. P. and Yildiz , A. ( 2016 ). The mammalian dynein-dynactin complex is a strong opponent to kinesin in a tug-of-war competition . Nat. Cell Biol. 18 , 1018 - 1024 . 10.1038/ncb3393 Bielli , A. , Thornqvist , P. O. , Hendrick , A. G. , Finn , R. , Fitzgerald...
Includes: Supplementary data
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Cytoskeleton
J Cell Sci (2021) 134 (23): jcs258510.
Published: 2 December 2021
.... We find that astral microtubule-bound She1 precludes the initiation of dynein-mediated spindle movements in mother cells by preventing association of dynein and dynactin with microtubule plus ends in this compartment. We also find that this requires interactions between She1 and the microtubule-bound...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (6): jcs227132.
Published: 15 March 2019
... enhance the stability of the complex that dynein forms with its required activator dynactin, leading to highly processive motility toward the microtubule minus end. Furthermore, activating adaptors mediate specific interactions of the motor complex with cargos such as Rab6-positive vesicles...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (8): 1555–1567.
Published: 15 April 2015
... microtubules, thereby driving nuclear migration. However, the precise mechanisms underlying dynein localization and activation remain unclear. Here, we identified three subunits of dynactin in fission yeast: Arp1, Mug5 and Jnm1 (also known as Mug1). These subunits transiently colocalized with dynein foci...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (19): 3187–3195.
Published: 1 October 2008
... on the nucleus. * Author for correspondence (e-mail: [email protected] ) 8 7 2008 © The Company of Biologists Limited 2008 2008 Dynactin Dynein Microtubules Migration Cell migration plays a central role in a variety of biological processes; tissue development...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2008) 121 (2): 155–161.
Published: 15 January 2008
...Haining Zhang; Ahna R. Skop; John G. White In many organisms, the dynein-dynactin complex is required for the alignment of the mitotic spindle onto the axis of polarity of a cell undergoing asymmetric cell division. How this complex transduces polarity cues, either intrinsic or extrinsic...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2006) 119 (21): 4431–4441.
Published: 1 November 2006
...Jean-Guy Delcros; Claude Prigent; Régis Giet The dynactin complex cooperates with the dynein complex in various systems for mitotic completion. Here we analysed the mitotic phenotype of Drosophila S2 cells following the knockdown of the dynactin subunit p150 Glued . We found that p150 Glued...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2006) 119 (13): 2758–2767.
Published: 1 July 2006
...Peter Watson; David J. Stephens Microtubule dynamics and function are regulated, at least in part, by a family of proteins that localize to microtubule plus-ends, and include EB1, CLIP-170 and the dynactin component p150 Glued . Plus-end pools of these proteins, notably dynactin, have been invoked...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2005) 118 (21): 5101–5108.
Published: 1 November 2005
... on their ability to interact with the dynein-dynactin motor complex. Our data also indicate that dynactin is required for the targeting of Nlp and ninein to the centrosome. Furthermore, phosphorylation of Nlp by the polo-like kinase 1 (Plk1) negatively regulates its association with dynactin. These findings...
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2003) 116 (18): 3793–3802.
Published: 15 September 2003
..., kinesin, had no effect. Surprisingly, overexpression of the protein p50 dynamitin, a subunit of the dynactin complex that links vesicular cargo to the dynein motor in minus directed vesicle trafficking, did not abrogate chlamydial migration even though host vesicle transport was inhibited. Nascent...
Journal Articles
J Cell Sci (2002) 115 (11): 2257–2264.
Published: 1 June 2002
... Microtubules Spindle Par proteins G-protein signalling Dynein Dynactin Asymmetric partitioning of cell fate determinants is employed to generate cell type diversity in a number of different organisms † ( Horvitz and Herskowitz,1992 ). However, asymmetric division does not necessarily result...
Journal Articles
J Cell Sci (2000) 113 (20): 3663–3671.
Published: 15 October 2000
... and detachment of tubular processes that interconnected adjacent organelles. Inhibition of cytoplasmic dynein based motility by overexpression of the dynactin subunit, dynamitin (p50), inhibited the movement of peroxisomes in vivo and interfered with the reestablishment of a uniform distribution of peroxisomes...
Journal Articles
J Cell Sci (1999) 112 (20): 3507–3518.
Published: 15 October 1999
...Imran B. Clark; David I. Meyer ABSTRACT Dynactin is a large multisubunit complex that regulates cytoplasmic dynein-mediated functions. To gain insight into the role of dynactin’s most abundant component, Arp1α was transiently overexpressed in mammalian cells. Arp1α overexpression resulted in a cell...
Journal Articles
J Cell Sci (1999) 112 (10): 1437–1447.
Published: 15 May 1999
...-interacting proteins has implicated the dynactin complex as the cytoplasmic dynein ‘receptor’ on organelles and kinetochores. Immunofluorescence microscopy using a total of six antibodies generated against the p150 Glued , Arp1 and dynamitin subunits of dynactin revealed a novel fraction of dynactin-positive...