... in Wnt negative-feedback regulation. Here, we show that axin and conductin differ in their functional interaction with the upstream Wnt pathway component Dvl. Conductin shows reduced binding to Dvl2 compared to axin, and degradation of β-catenin by conductin is only poorly blocked by Dvl2. We propose...

... ) 2 2 2010 © 2010. 2010 Wnt β-catenin Frizzled Dvl KSRP RNA decay Canonical pathway Lef/Tcf Primitive endoderm K-Homology splicing regulatory protein Wnt signaling is crucial during normal embryonic development and cellular homeostasis ( Logan and Nusse, 2004 ; Malbon...

.... * Author for correspondence (e-mail: [email protected] ) 5 12 2005 © The Company of Biologists Limited 2006 2006 Wnt Frizzled LRP Arrow β-catenin Ryk Dishevelled Dvl Wnts are secreted lipid-modified glycoproteins ( Willert et al., 2003 ) found in all metozoans examined...