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Keywords: Drug response
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Journal Articles
J Cell Sci (2021) 134 (16): jcs256461.
Published: 23 August 2021
... these to classical two-dimensional (2D) cultures in various aspects of tumor phenotype and drug responses. Compared to 2D monolayers, the 3D spheroids showed significant increases in migration capacity, stemness characteristics, hypoxia and drug resistance. Co-culture with endothelial cells, which mimics essential...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (1): 203–218.
Published: 01 January 2017
... as preclinical systems to mimic physiologic drug responses. We provide evidence for strong changes of proliferation and metabolic capacity in three dimensions by systematically analyzing spheroids of colon cancer cell lines. Spheroids showed relative lower activities in the AKT, mammalian target of rapamycin...
Includes: Supplementary data