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1-20 of 21
Keywords: Drp1
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Journal Articles
In collection:
Organelles
Xiumei He, Liang Wang, Hoi Ying Tsang, Xiaonan Liu, Xiaofeng Yang, Shiming Pu, Ziqi Guo, Cheng Yang, Qiong Wu, Zuping Zhou, Xiaobo Cen, Hongxia Zhao
Journal:
Journal of Cell Science
J Cell Sci (2024) 137 (8): jcs261612.
Published: 30 April 2024
... of mitochondria. Conversely, overexpression of GTPBP8 shifted mitochondrial morphology from tubular to fragmented. Notably, the induced mitochondrial fragmentation from GTPBP8 overexpression was inhibited in cells either depleted of the mitochondrial fission protein Drp1 (also known as DNM1L) or carrying mutated...
Includes: Supplementary data
Journal Articles
In collection:
Organelles
Yi-Shyun Lai, Cheng-Chi Chang, Yong-Yi Chen, Thi My Hang Nguyen, Jixuan Xu, Ying-Chi Chen, Yu-Fen Chang, Chia-Yih Wang, Pai-Sheng Chen, Shih-Chieh Lin, I-Chen Peng, Shaw-Jenq Tsai, Wen-Tai Chiu
Journal:
Journal of Cell Science
J Cell Sci (2023) 136 (12): jcs260819.
Published: 21 June 2023
... but not the Ser637 residue of the mitochondrial fission protein, dynamin-related protein 1 (DRP1, encoded by DNM1L ), via the activation of Ca 2+ -dependent kinases CaMKII, ERK and CDK1. However, optogenetically engineered Ca 2+ signaling did not activate calcineurin phosphatase to dephosphorylate DRP1 at Ser637...
Includes: Supplementary data
Journal Articles
In collection:
Autophagy
Journal:
Journal of Cell Science
J Cell Sci (2023) 136 (6): jcs246348.
Published: 24 March 2023
... for Vps1 accumulation and activity on peroxisomes. Dynamin-related protein Peroxisome Autophagy Drp1 University of Sheffield http://dx.doi.org/10.13039/501100000858 Saudi Arabia Cultural Bureau in London http://dx.doi.org/10.13039/100012363 University of Bisha...
Includes: Supplementary data
Journal Articles
Gabriella L. Robertson, Stellan Riffle, Mira Patel, Caroline Bodnya, Andrea Marshall, Heather K. Beasley, Edgar Garza-Lopez, Jianqiang Shao, Zer Vue, Antentor Hinton, Jr, Maria S. Stoll, Sholto de Wet, Rensu P. Theart, Ram Prosad Chakrabarty, Ben Loos, Navdeep S. Chandel, Jason A. Mears, Vivian Gama
Journal:
Journal of Cell Science
J Cell Sci (2023) 136 (3): jcs260370.
Published: 10 February 2023
... Gama ABSTRACT Mitochondria and peroxisomes are dynamic signaling organelles that constantly undergo fission, driven by the large GTPase dynamin-related protein 1 (DRP1; encoded by DNM1L ). Patients with de novo heterozygous missense mutations in DNM1L present with encephalopathy due to defective...
Includes: Supplementary data
Journal Articles
Qiancong Zhao, Shun Yan, Jin Lu, Danitra J. Parker, Huiying Wu, Qianchuang Sun, David K. Crossman, Shanrun Liu, Qin Wang, Hiromi Sesaki, Kasturi Mitra, Kexiang Liu, Kai Jiao
Journal:
Journal of Cell Science
J Cell Sci (2022) 135 (4): jcs258956.
Published: 21 February 2022
... in determining mitochondrial activity. Dnm1l encodes a dynamin-related GTPase, Drp1, which is required for mitochondrial fission. To investigate the role of Drp1 in cardiogenesis during the embryonic metabolic shift period, we specifically inactivated Dnm1l in second heart field-derived structures. Mutant...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2022) 135 (2): jcs257808.
Published: 17 January 2022
... MFN2 mutation, R364W, results in the generation of elongated, interconnected mitochondria. However, the mechanism leading to this mitochondrial aberration remains poorly understood. Here, we show that mitochondrial hyperfusion in the presence of R364W-MFN2 is due to increased degradation of DRP1 (also...
Includes: Supplementary data
Journal Articles
In collection:
Organelles
Journal:
Journal of Cell Science
J Cell Sci (2020) 133 (18): jcs247593.
Published: 15 September 2020
...-related protein 1 (DRP1, also known as DNML1) is highly expressed in brown adipose tissue compared to expression in white adipose tissue, and these expression levels increase during brown adipocyte differentiation. Our results reveal that the inhibition of DRP1 using mdivi-1 mitigates beige adipocyte...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2019) 132 (18): jcs234435.
Published: 23 September 2019
... as ‘clouds’ around depolarized mitochondria. We have previously shown that calcium-induced actin stimulates increases in both mitochondrial calcium and recruitment of the dynamin GTPase Drp1 (also known as DNM1L). In contrast, depolarization-induced actin is temporally associated with extensive mitochondrial...
Includes: Supplementary data
Journal Articles
In collection:
Organelles
Hideaki Tanaka, Tomohiko Okazaki, Saeko Aoyama, Mutsumi Yokota, Masato Koike, Yasushi Okada, Yukio Fujiki, Yukiko Gotoh
Journal:
Journal of Cell Science
J Cell Sci (2019) 132 (11): jcs224766.
Published: 31 May 2019
... fibroblasts (MEFs) in a manner dependent on Drp1 (also known as DNM1L). Conversely, treatment with 4-PBA, which results in peroxisome proliferation, resulted in mitochondrial elongation in wild-type MEFs, but not in Pex3-knockout MEFs. We further found that peroxisome deficiency increased the levels...
Includes: Supplementary data
Journal Articles
In collection:
Organelles
Journal:
Journal of Cell Science
J Cell Sci (2017) 130 (18): 2953–2960.
Published: 15 September 2017
... the cytosolic face. In this Review, we summarize the role of proteins from the dynamin superfamily in mitochondrial division. This includes recent findings highlighting that dynamin-2 (Dnm2) is involved in mitochondrial scission, which led to the reappraisal of the role of dynamin-related protein 1 (Drp1; also...
Journal Articles
Danitra J. Parker, Archana Iyer, Shikha Shah, Aida Moran, Anita B. Hjelmeland, Malay Kumar Basu, Runhua Liu, Kasturi Mitra
Journal:
Journal of Cell Science
J Cell Sci (2015) 128 (22): 4171–4182.
Published: 15 November 2015
... pool of CycE (mtCycE) lacking a key phosphorylation required for its degradation. Loss of the mitochondrial fission protein dynamin-related protein 1 (Drp1, SwissProt O00429 in humans) augments mitochondrial respiration and elevates the mtCycE pool allowing CycE deregulation, cell cycle alterations...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2015) 128 (17): 3239–3249.
Published: 1 September 2015
... to a D ebcl - and Drp1 -dependent reactive oxygen species production, which in turn activates the Jun Kinase pathway to trigger cell death. Moreover, we show that Debcl and Drp1 can interact and that Buffy inhibits this interaction. Notably, Debcl modulates Drp1 mitochondrial localization during...
Includes: Supplementary data
Journal Articles
In collection:
Metabolism
Christian Pennanen, Valentina Parra, Camila López-Crisosto, Pablo E. Morales, Andrea del Campo, Tomás Gutierrez, Pablo Rivera-Mejías, Jovan Kuzmicic, Mario Chiong, Antonio Zorzano, Beverly A. Rothermel, Sergio Lavandero
Journal:
Journal of Cell Science
J Cell Sci (2014) 127 (12): 2659–2671.
Published: 15 June 2014
... that norepinephrine acts through α 1 -adrenergic receptors to increase cytoplasmic Ca 2+ , activating calcineurin and promoting migration of the fission protein Drp1 (encoded by Dnml1 ) to mitochondria. Dominant-negative Drp1 (K38A) not only prevented mitochondrial fission, it also blocked hypertrophic growth...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2014) 127 (10): 2313–2325.
Published: 15 May 2014
... oxidative phosphorylation are protected from damage-induced fission through the impaired recruitment and activation of mitochondrial DRP1. Using OMA1-deficient MEF cells, we show that the preservation of a stable pool of L-OPA1 at the inner mitochondrial membrane is sufficient to delay mitophagy, even...
Includes: Supplementary data
Journal Articles
Kenta Onoue, Akihiro Jofuku, Reiko Ban-Ishihara, Takaya Ishihara, Maki Maeda, Takumi Koshiba, Takashi Itoh, Mitsunori Fukuda, Hidenori Otera, Toshihiko Oka, Hiroyoshi Takano, Noboru Mizushima, Katsuyoshi Mihara, Naotada Ishihara
Journal:
Journal of Cell Science
J Cell Sci (2013) 126 (1): 176–185.
Published: 1 January 2013
... Fis1 recruits the mitochondrial-fission-regulating GTPase Dnm1 to mitochondrial fission sites. However, the function of its mammalian homologue remains enigmatic because it has been reported to be dispensable for the mitochondrial recruitment of Drp1, a mammalian homologue of Dnm1. We identified...
Includes: Supplementary data
Journal Articles
Wei Qian, Serah Choi, Gregory A. Gibson, Simon C. Watkins, Christopher J. Bakkenist, Bennett Van Houten
Journal:
Journal of Cell Science
J Cell Sci (2012) 125 (23): 5745–5757.
Published: 1 December 2012
...Wei Qian; Serah Choi; Gregory A. Gibson; Simon C. Watkins; Christopher J. Bakkenist; Bennett Van Houten Summary Mitochondrial fission and fusion cycles are integrated with cell cycle progression. In this paper, we demonstrate that the inhibition of mitochondrial fission protein Drp1 causes...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2010) 123 (6): 917–926.
Published: 15 March 2010
... by downregulation of the expression of Fis1 and Drp1, two proteins regulating mitochondrial fission. Targeted photodamage of mitochondria induced the formation of reactive oxygen species (ROS), which triggered mitochondrial fragmentation and loss of membrane potential in young cells, whereas senescent cells proved...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2010) 123 (4): 619–626.
Published: 15 February 2010
... (hFis1), dynamin-related protein 1 (Drp1) and mitofusin 2 (Mfn2), key proteins in the control of mitochondrial fission and fusion. However, how these interactions control mitochondrial dynamics, and cellular function has remained obscure. Here, we show that shRNA-mediated MARCH5 knockdown promoted...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2007) 120 (7): 1178–1188.
Published: 1 April 2007
...Rodolfo Zunino; Astrid Schauss; Peter Rippstein; Miguel Andrade-Navarro; Heidi M. McBride Mitochondria are dynamic organelles that undergo regulated fission and fusion events that are essential to maintain metabolic stability. We previously demonstrated that the mitochondrial fission GTPase DRP1...
Includes: Multimedia, Supplementary data
Journal Articles
Giovanni Benard, Nadège Bellance, Dominic James, Philippe Parrone, Helder Fernandez, Thierry Letellier, Rodrigue Rossignol
Journal:
Journal of Cell Science
J Cell Sci (2007) 120 (5): 838–848.
Published: 1 March 2007
... interfering RNA (siRNA) targeting DRP1 , which revealed the importance of membrane fluidity on the control of bioenergetics. Second, we followed the effect of rotenone, a specific inhibitor of respiratory chain complex I, which causes large structural perturbations, once a threshold was reached. Last, we...
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