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Keywords: Drp1
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Journal Articles
In collection:
Organelles
J Cell Sci (2024) 137 (8): jcs261612.
Published: 30 April 2024
... of mitochondria. Conversely, overexpression of GTPBP8 shifted mitochondrial morphology from tubular to fragmented. Notably, the induced mitochondrial fragmentation from GTPBP8 overexpression was inhibited in cells either depleted of the mitochondrial fission protein Drp1 (also known as DNM1L) or carrying mutated...
Includes: Supplementary data
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Journal Articles
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Autophagy
J Cell Sci (2023) 136 (6): jcs246348.
Published: 24 March 2023
... for Vps1 accumulation and activity on peroxisomes. Dynamin-related protein Peroxisome Autophagy Drp1 University of Sheffield http://dx.doi.org/10.13039/501100000858 Saudi Arabia Cultural Bureau in London http://dx.doi.org/10.13039/100012363 University of Bisha...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2022) 135 (4): jcs258956.
Published: 21 February 2022
... in determining mitochondrial activity. Dnm1l encodes a dynamin-related GTPase, Drp1, which is required for mitochondrial fission. To investigate the role of Drp1 in cardiogenesis during the embryonic metabolic shift period, we specifically inactivated Dnm1l in second heart field-derived structures. Mutant...
Includes: Supplementary data
Journal Articles
Journal Articles
In collection:
Organelles
J Cell Sci (2020) 133 (18): jcs247593.
Published: 15 September 2020
...-related protein 1 (DRP1, also known as DNML1) is highly expressed in brown adipose tissue compared to expression in white adipose tissue, and these expression levels increase during brown adipocyte differentiation. Our results reveal that the inhibition of DRP1 using mdivi-1 mitigates beige adipocyte...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (18): jcs234435.
Published: 23 September 2019
... as ‘clouds’ around depolarized mitochondria. We have previously shown that calcium-induced actin stimulates increases in both mitochondrial calcium and recruitment of the dynamin GTPase Drp1 (also known as DNM1L). In contrast, depolarization-induced actin is temporally associated with extensive mitochondrial...
Includes: Supplementary data
Journal Articles
In collection:
Organelles
J Cell Sci (2019) 132 (11): jcs224766.
Published: 31 May 2019
... fibroblasts (MEFs) in a manner dependent on Drp1 (also known as DNM1L). Conversely, treatment with 4-PBA, which results in peroxisome proliferation, resulted in mitochondrial elongation in wild-type MEFs, but not in Pex3-knockout MEFs. We further found that peroxisome deficiency increased the levels...
Includes: Supplementary data
Journal Articles
In collection:
Organelles
J Cell Sci (2017) 130 (18): 2953–2960.
Published: 15 September 2017
... the cytosolic face. In this Review, we summarize the role of proteins from the dynamin superfamily in mitochondrial division. This includes recent findings highlighting that dynamin-2 (Dnm2) is involved in mitochondrial scission, which led to the reappraisal of the role of dynamin-related protein 1 (Drp1; also...
Journal Articles
J Cell Sci (2015) 128 (22): 4171–4182.
Published: 15 November 2015
... pool of CycE (mtCycE) lacking a key phosphorylation required for its degradation. Loss of the mitochondrial fission protein dynamin-related protein 1 (Drp1, SwissProt O00429 in humans) augments mitochondrial respiration and elevates the mtCycE pool allowing CycE deregulation, cell cycle alterations...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (17): 3239–3249.
Published: 1 September 2015
... to a D ebcl - and Drp1 -dependent reactive oxygen species production, which in turn activates the Jun Kinase pathway to trigger cell death. Moreover, we show that Debcl and Drp1 can interact and that Buffy inhibits this interaction. Notably, Debcl modulates Drp1 mitochondrial localization during...
Includes: Supplementary data
Journal Articles
In collection:
Metabolism
J Cell Sci (2014) 127 (12): 2659–2671.
Published: 15 June 2014
... that norepinephrine acts through α 1 -adrenergic receptors to increase cytoplasmic Ca 2+ , activating calcineurin and promoting migration of the fission protein Drp1 (encoded by Dnml1 ) to mitochondria. Dominant-negative Drp1 (K38A) not only prevented mitochondrial fission, it also blocked hypertrophic growth...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2010) 123 (4): 619–626.
Published: 15 February 2010
... (hFis1), dynamin-related protein 1 (Drp1) and mitofusin 2 (Mfn2), key proteins in the control of mitochondrial fission and fusion. However, how these interactions control mitochondrial dynamics, and cellular function has remained obscure. Here, we show that shRNA-mediated MARCH5 knockdown promoted...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (7): 1178–1188.
Published: 1 April 2007
...Rodolfo Zunino; Astrid Schauss; Peter Rippstein; Miguel Andrade-Navarro; Heidi M. McBride Mitochondria are dynamic organelles that undergo regulated fission and fusion events that are essential to maintain metabolic stability. We previously demonstrated that the mitochondrial fission GTPase DRP1...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2007) 120 (5): 838–848.
Published: 1 March 2007
... interfering RNA (siRNA) targeting DRP1 , which revealed the importance of membrane fluidity on the control of bioenergetics. Second, we followed the effect of rotenone, a specific inhibitor of respiratory chain complex I, which causes large structural perturbations, once a threshold was reached. Last, we...