... we explore the hypothesis that a reduction in sarcoplasmic reticulum (SR) Ca 2+ concentration ([Ca 2+ ] SR ) is at the origin of this loss of Ca 2+ homeostasis. We engineered Drosophila melanogaster to express the Ca 2+ indicator GAP3 targeted to muscle SR, and we developed a new method to calibrate...

... contractility Developmental mechanics Non-muscle Myosin-II Zipper Drosophila melanogaster Tissue function frequently relies on the underlying shapes and organization of its constituent cells. Diverse processes are responsible for coordinating the morphology and arrangement of cells into complex...

...]. R.D. was supported by a post-doctoral fellowship from the Fondation ARC pour la Recherche sur le Cancer. References Abad , J. P. and Villasante , A. ( 1999 ). The 3′ non-coding region of the Drosophila melanogaster HeT-A telomeric retrotransposon contains sequences with propensity...

... with cancer with a marker indicative of invasiveness. As such, we suggest a mechanism by which JAK/STAT pathway signalling may promote metastasis. Drosophila melanogaster Haematopoiesis Tumorigenesis JAK Rho1 Total RNA extracted using TriReagent® (Sigma-Aldrich, USA) from Kc 167 cells, third...

.... 24 05 2013 15 10 2013 © 2014. Published by The Company of Biologists Ltd 2014 Erect wing Mitochondrial fusion Opa1-like Indirect flight muscle Drosophila melanogaster Biogenesis and dynamic changes in shape and size of mitochondria are important for tissue growth...

..., a novel player of Drosophila asymmetric divisions, reveals two distinct steps in inscuteable apical localization.   Cell   100 , 399 – 409 . 10.1016/S0092-8674(00)80676-5 Dynein Formins Small GTPases Spindle orientation Drosophila melanogaster Oriented cell division is essential...

.... Published by The Company of Biologists Ltd 2013 Tubular sclerosis complex Intestinal stem cell TORC1 Nutrition Notch Delamination Drosophila melanogaster The intestinal epithelium is a rapidly renewing tissue and the residing intestinal stem cells (ISCs) are responsible for this high...

... ( prantera@unitus.it ) 4 06 2013 © 2013. Published by The Company of Biologists Ltd 2013 Meiosis rae1 RNA-export factor Drosophila melanogaster Mitotic cell cycle regulator The discovery of genes underlying regulation and execution of meiotic events is essential to gain...

... and D253 in Drosophila melanogaster ). These residues are highly conserved and predicted to play a major role in the protein–protein interactions between SNARE complexes by forming an ionic couple. Accordingly, we generated transgenic Drosophila lines expressing SNAREs mutated in these residues...

... ). Indirect suppression involving behavioral mutants with altered nerve excitability in Drosophila melanogaster.   Genetics   100 , 597 – 614 . Gnerer   J. P. , Kreber   R. A. , Ganetzky   B. ( 2006 ). wasted away, a Drosophila mutation in triosephosphate isomerase, causes paralysis...

...) and UASCrb FL (a gift from E. Knust). nulloGal4 drives ubiquitous expression in the ectoderm and salPEGal4 in the wing pouch of imaginal discs. Crumbs Drosophila melanogaster Cell architecture Morphogenesis Morphogenesis and organogenesis rely on the capacity of cells...

... in the salivary glands of Drosophila melanogaster: characterization of the glue proteins and their developmental appearance.   Cell   9 , 365 – 373 . 10.1016/0092-8674(76)90081-7 Bell   M. , Wang   H. , Chen   H. , McLenithan   J. C. , Gong   D. W. , Yang   R. Z. , Yu   D. , Fried...

... accumulation of dynactin.   Biochem. Biophys. Res. Commun.   359 , 811 – 816 . 10.1016/j.bbrc.2007.05.188 Bobinnec   Y. , Marcaillou   C. , Morin   X. , Debec   A. ( 2003 ). Dynamics of the endoplasmic reticulum during early development of Drosophila melanogaster.   Cell Motil...

...Daishi Kitazawa; Masamitsu Yamaguchi; Hajime Mori; Yoshihiro H. Inoue Summary The coatomer protein complex, COPI, mediates retrograde vesicle transport from the Golgi apparatus to the ER. Here, we investigated the meiotic phenotype of Drosophila melanogaster spermatocytes expressing dsRNA of 52...

... COPI ARF ARF-GEF GBF1 Gartenzwerg Drosophila melanogaster Tracheal system Epithelial tube Membrane traffic The dimensions and shapes of epithelial tubules in many organs, such as vertebrate kidneys, lungs and vascular systems, are precisely controlled to ensure normal organ function...

... both the activity of the correction mechanism and the architecture of the centromere. * Author for correspondence ( cesunkel@ibmc.up.pt ) 18 11 2011 © 2012. 2012 Cell cycle Drosophila melanogaster Kinetochore Mitosis Polo Distribution of sister chromatids during...

... affecting the Drosophila melanogaster follicular epithelium, we isolated a mutation in CoREST that disrupts the Notch-dependent mitotic-to-endocycle switch of follicle cells at stage 6 of oogenesis. We show that Drosophila CoREST positively regulates Notch signaling, acting downstream of the proteolytic...

... factors such as the chromosome passenger complex. * Author for correspondence ( mckim@rci.rutgers.edu ) 4 7 2011 © 2011. 2011 Meiosis Mitosis Microtubule Drosophila melanogaster Acentrosomal spindle Chromosome segregation Ran is a member of the Ras family of small...

...Heiko Meyer; Olga Vitavska; Helmut Wieczorek According to a classic tenet, sugar transport across animal membranes is restricted to monosaccharides. Here, we present the first report of an animal sucrose transporter, SCRT, which we detected in Drosophila melanogaster at each developmental stage. We...

... ) within the C-terminal region, which is cleaved by botulinum neurotoxin A, with consequent blockade of neuroexocytosis. The possibility that it may play an important role in the function of the neuroexocytosis machinery was tested at neuromuscular junctions of Drosophila melanogaster larvae expressing...