... we explore the hypothesis that a reduction in sarcoplasmic reticulum (SR) Ca 2+ concentration ([Ca 2+ ] SR ) is at the origin of this loss of Ca 2+ homeostasis. We engineered Drosophila melanogaster to express the Ca 2+ indicator GAP3 targeted to muscle SR, and we developed a new method to calibrate...

... can fine-tune tissue morphology during development. Rho signaling Epithelial morphogenesis Actomyosin contractility Developmental mechanics Non-muscle Myosin-II Zipper Drosophila melanogaster National Institutes of Health 10.13039/100000002 GM117708 HD083185 GM007229...

... or financial interests. 17 12 2014 18 3 2015 © 2015. Published by The Company of Biologists Ltd 2015 Drosophila melanogaster Telomere Capping protein Male germline Spermatogenesis Telomeres are specialized structures that organize the extremities of linear chromosomes...

.... 24 05 2013 15 10 2013 © 2014. Published by The Company of Biologists Ltd 2014 Erect wing Mitochondrial fusion Opa1-like Indirect flight muscle Drosophila melanogaster Biogenesis and dynamic changes in shape and size of mitochondria are important for tissue growth...

... provided that the original work is properly attributed. Drosophila melanogaster Haematopoiesis Tumorigenesis JAK Rho1 The cellular co-ordination and exchange of information required during development is mediated by a relatively small group of evolutionarily conserved signal...

... spindle orientation. * Authors for correspondence ( [email protected] ; [email protected] ) 2 07 2013 © 2013. Published by The Company of Biologists Ltd 2013 Dynein Formins Small GTPases Spindle orientation Drosophila melanogaster Oriented cell division is essential...

.... Published by The Company of Biologists Ltd 2013 Tubular sclerosis complex Intestinal stem cell TORC1 Nutrition Notch Delamination Drosophila melanogaster The intestinal epithelium is a rapidly renewing tissue and the residing intestinal stem cells (ISCs) are responsible for this high...

... premeiotic, meiotic and early postmeiotic stages of Drosophila melanogaster spermatogenesis.   J. Cell Sci.   107 , 3521 – 3534 . Chintapalli   V. R. , Wang   J. , Dow   J. A. ( 2007 ). Using FlyAtlas to identify better Drosophila melanogaster models of human disease.   Nat. Genet.   39...

... and D253 in Drosophila melanogaster ). These residues are highly conserved and predicted to play a major role in the protein–protein interactions between SNARE complexes by forming an ionic couple. Accordingly, we generated transgenic Drosophila lines expressing SNAREs mutated in these residues...

.... * Author for correspondence ( [email protected] ) 4 04 2013 © 2013. Published by The Company of Biologists Ltd 2013 TPI Triosephosphate isomerase Drosophila melanogaster Glycolysis Longevity Locomotor function Triosephosphate isomerase (TPI) is a homodimeric enzyme...

[email protected] ) 4 03 2013 © 2013. Published by The Company of Biologists Ltd 2013 Crumbs Drosophila melanogaster Cell architecture Morphogenesis Morphogenesis and organogenesis rely on the capacity of cells to coordinately change shape. Shape changes in epithelial cells...

... identified the first members of a novel and evolutionarily conserved family of lipid storage regulators, which are also required to properly position LDs within cells. References Beckendorf   S. K. , Kafatos   F. C. ( 1976 ). Differentiation in the salivary glands of Drosophila melanogaster...

... Bobinnec   Y. , Marcaillou   C. , Morin   X. , Debec   A. ( 2003 ). Dynamics of the endoplasmic reticulum during early development of Drosophila melanogaster.   Cell Motil. Cytoskeleton   54 , 217 – 225 . 10.1002/cm.10094 Brill   J. A. , Hime   G. R. , Scharer–Schuksz   M...

...Daishi Kitazawa; Masamitsu Yamaguchi; Hajime Mori; Yoshihiro H. Inoue Summary The coatomer protein complex, COPI, mediates retrograde vesicle transport from the Golgi apparatus to the ER. Here, we investigated the meiotic phenotype of Drosophila melanogaster spermatocytes expressing dsRNA of 52...

... garz activity leads to increased retrograde trafficking. Thus, garz might regulate epithelial tube morphogenesis and secretion by controlling the rate of trafficking of COPI vesicles. Golgi COPI ARF ARF-GEF GBF1 Gartenzwerg Drosophila melanogaster Tracheal system Epithelial tube...

... attachment, in contrast to inhibition of the kinase that results mainly in unattached and lateral-interacting chromosomes, as has been described for human cells ( Lenart et al., 2007 ). POLO kinase was first identified in Drosophila melanogaster ( Sunkel and Glover, 1988 ) and subsequently shown...

... affecting the Drosophila melanogaster follicular epithelium, we isolated a mutation in CoREST that disrupts the Notch-dependent mitotic-to-endocycle switch of follicle cells at stage 6 of oogenesis. We show that Drosophila CoREST positively regulates Notch signaling, acting downstream of the proteolytic...

... factors such as the chromosome passenger complex. * Author for correspondence ( [email protected] ) 4 7 2011 © 2011. 2011 Meiosis Mitosis Microtubule Drosophila melanogaster Acentrosomal spindle Chromosome segregation Ran is a member of the Ras family of small...

...Heiko Meyer; Olga Vitavska; Helmut Wieczorek According to a classic tenet, sugar transport across animal membranes is restricted to monosaccharides. Here, we present the first report of an animal sucrose transporter, SCRT, which we detected in Drosophila melanogaster at each developmental stage. We...

... ) within the C-terminal region, which is cleaved by botulinum neurotoxin A, with consequent blockade of neuroexocytosis. The possibility that it may play an important role in the function of the neuroexocytosis machinery was tested at neuromuscular junctions of Drosophila melanogaster larvae expressing...