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Keywords: Drosophila
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Journal Articles
J Cell Sci jcs.259547.
Published: 11 May 2022
... genome editing to delete the PDZ domain-encoding region from Drosophila dishevelled . Canonical Wg signalling is entirely normal in these deletion mutants, however they show defects in multiple contexts controlled by noncanonical Wnt signalling such as planar polarity. We use NMR spectroscopy to identify...
Journal Articles
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Lipid Biology
J Cell Sci (2022) 135 (7): jcs259092.
Published: 14 April 2022
... cells are induced to liberate fatty acids from lipid droplets. We have shown a non-canonical role for a subset of peroxisome-assembly [Peroxin (Pex)] proteins in this process in Drosophila . Transmembrane proteins Pex3, Pex13 and Pex14 were observed to surround newly formed lipid droplets. Trafficking...
Includes: Supplementary data
Journal Articles
In collection:
Membrane Trafficking
J Cell Sci (2022) 135 (3): jcs259590.
Published: 3 February 2022
... extensively in cultured cells, studies of EVs in vivo have remained scarce. We report here that EVs are present in the developing lumen of tracheal tubes in Drosophila embryos. We define two distinct EV subpopulations, one of which contains the Munc13-4 (also known as UNC13D) homolog Staccato (Stac...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (2): jcs259132.
Published: 24 January 2022
...Eliana F. Torres-Zelada; Smitha George; Hannah R. Blum; Vikki M. Weake ABSTRACT The histone acetyltransferase Gcn5 is critical for gene expression and development. In Drosophila , Gcn5 is part of four complexes (SAGA, ATAC, CHAT and ADA) that are essential for fly viability and have key roles...
Includes: Supplementary data
Journal Articles
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Imaging
J Cell Sci (2021) 134 (24): jcs259570.
Published: 16 December 2021
... (PAINT) routinely gives 30 nm resolution or better at depths greater than 20 µm. This revealed that the nuclear pores are nonrandomly distributed in most Drosophila tissues, in contrast to what is seen in cultured cells. Lamin Dm 0 shows a complementary localization to the nuclear pores, suggesting...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (23): jcs258891.
Published: 9 December 2021
... phosphorylation. However, the in vivo relevance of the phosphorylation of WAVE proteins remains largely unknown. Here, we identified casein kinase I alpha (CK1α) as a regulator of WAVE, thereby controlling cell shape and cell motility in Drosophila macrophages. CK1α binds and phosphorylates WAVE in vitro...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2021) 134 (21): jcs258973.
Published: 5 November 2021
... function for the distribution of F-actin plus and minus ends. In syncytial Drosophila embryos, Rho1 signaling is high between actin caps, i.e. the cortical intercap region. Capping protein binds to free plus ends of F-actin to prevent elongation of the filament. Capping protein has served as a marker...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2021) 134 (20): jcs258512.
Published: 22 October 2021
... in neurons. In the present study, we demonstrate that the Drosophila ankyrin repeat and KH domain-containing protein Mask negatively affects MT stability in both larval muscles and motor neurons. In larval muscles, loss-of-function of mask increases MT polymer length, and in motor neurons, loss of mask...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2022) 135 (5): jcs259086.
Published: 20 August 2021
... membrane contact sites to be described; however, the protein composition and molecular function of these sites is still emerging. Here, we leverage yeast and Drosophila model systems to uncover a novel role for the Hobbit (Hob) proteins at ER–PM contact sites. We find that Hobbit localizes to ER–PM contact...
Includes: Supplementary data
Journal Articles
In collection:
Membrane Trafficking
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2021) 134 (15): jcs259037.
Published: 3 August 2021
...); after budding from the TGN, granules undergo modifications, including an increase in size. These changes occur during a poorly understood process called secretory granule maturation. Here, we leverage the Drosophila larval salivary glands as a model to characterize a novel role for Rab GTPases during...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2021) 134 (14): jcs254037.
Published: 23 July 2021
...Janet K. Jang; Amy C. Gladstein; Arunika Das; Joanatta G. Shapiro; Zachary L. Sisco; Kim S. McKim ABSTRACT Meiosis in female oocytes lacks centrosomes, the microtubule-organizing centers. In Drosophila oocytes, meiotic spindle assembly depends on the chromosomal passenger complex (CPC...
Includes: Supplementary data
Journal Articles
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Stem Cells
J Cell Sci (2021) 134 (14): jcs258757.
Published: 22 July 2021
..., this process must be tightly controlled. Here, we show that a translational regulator, me31B , plays a critical role in preventing excess dedifferentiation in the Drosophila male germline: in the absence of me31B , spermatogonia dedifferentiate into germline stem cells (GSCs) at a dramatically elevated...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2021) 134 (10): jcs258603.
Published: 24 May 2021
...Sandrine Pizette; Tamás Matusek; Bram Herpers; Pascal P. Thérond; Catherine Rabouille ABSTRACT In metazoans, tissue growth and patterning is partly controlled by the Hedgehog (Hh) morphogen. Using immuno-electron microscopy on Drosophila wing imaginal discs, we identified a cellular structure...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (9): jcs257592.
Published: 11 May 2021
... regulated by secreted glycan-binding lectins. Using the Drosophila neuromuscular junction (NMJ) as a model glutamatergic synapse, we identify a new Ca 2+ -binding (C-type) lectin, Lectin-galC1 (LGC1), which modulates presynaptic function and neurotransmission strength. We find that LGC1 is enriched...
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2021) 134 (9): jcs258269.
Published: 7 May 2021
... and regulation patterns of SLK in development and disease, that make it a potential therapeutic target. Drosophila SLK STK2 Ste20 kinase Animal models Signaling There are over 500 different mammalian protein kinases ( Hunter, 1987 , 1991 , 1995 ), which can be further divided into four...
Journal Articles
In collection:
Polarity , Stem Cells
J Cell Sci (2021) 134 (6): jcs257022.
Published: 26 March 2021
...Yasushi Izumi; Kyoko Furuse; Mikio Furuse ABSTRACT Smooth septate junctions (sSJs) regulate the paracellular transport in the intestinal tract in arthropods. In Drosophila , the organization and physiological function of sSJs are regulated by at least three sSJ-specific membrane proteins: Ssk, Mesh...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2021) 134 (6): jcs251231.
Published: 26 March 2021
...Tsuyoshi Shoda; Kanta Yamazoe; Yuri Tanaka; Yuki Asano; Yoshihiro H. Inoue ABSTRACT After centrosome duplication, centrioles elongate before M phase. To identify genes required for this process and to understand the regulatory mechanism, we investigated the centrioles in Drosophila premeiotic...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2021) 134 (4): jcs246496.
Published: 17 February 2021
... interactions. The Drosophila syncytial embryo represents a simple pseudo-tissue, with its nuclei orderly embedded in a structured cytoskeletal matrix at the embryonic cortex with no physical separation by cellular membranes. Here, we review the stereotypic dynamics and regulation of the cytoskeleton...
Journal Articles
J Cell Sci (2021) 134 (2): jcs253096.
Published: 22 January 2021
...Darya A. Kalashnikova; Daniil A. Maksimov; Stanislav E. Romanov; Petr P. Laktionov; Dmitry E. Koryakov ABSTRACT We explored functional roles of two H3K9-specific histone methyltransferases of Drosophila melanogaster , SetDB1 (also known as Eggless) and Su(var)3-9. Using the DamID approach, we...
Includes: Supplementary data
Journal Articles
In collection:
Membrane Trafficking
J Cell Sci (2020) 133 (24): jcs245571.
Published: 29 December 2020
...Syara Fujii; Kazuo Kurokawa; Tatsuya Tago; Ryota Inaba; Arata Takiguchi; Akihiko Nakano; Takunori Satoh; Akiko K. Satoh ABSTRACT Golgi stacks are the basic structural units of the Golgi. Golgi stacks are separated from each other and scattered in the cytoplasm of Drosophila cells. Here, we report...
Includes: Supplementary data