...Abhishikt David Solomon; Odjo G. Gouttia; Ling Wang; Songli Zhu; Feifei Wang; Yanqui Li; Mohammadjavad Paydar; Tadayoshi Bessho; Benjamin H. Kwok; Aimin Peng ABSTRACT Double-strand breaks (DSBs) in DNA pose a critical threat to genomic integrity, potentially leading to the onset and progression...

... controlling the G1/S transition. It also ensures proper oxidative and cell wall stress responses. Previously, we found that Swi6 was crucial for the survival of genotoxic stress. Here, we show that a lack of Swi6 causes replication stress leading to double-strand break (DSB) formation, inefficient DNA repair...

...P. M. Krawczyk; T. Borovski; J. Stap; T. Cijsouw; R. ten Cate; J. P. Medema; R. Kanaar; N. A. P. Franken; J. A. Aten DNA double-strand breaks (DSBs) can efficiently kill cancer cells, but they can also produce unwanted chromosome rearrangements when DNA ends from different DSBs are erroneously...

...Karine Dubrana; Haico van Attikum; Florence Hediger; Susan M. Gasser Double-strand breaks (DSB) in yeast lead to the formation of repair foci and induce a checkpoint response that requires both the ATR-related kinase Mec1 and its target, Rad53. By combining high-resolution confocal microscopy...

...Janet K. Jang; Dalia E. Sherizen; Rajal Bhagat; Elizabeth A. Manheim; Kim S. McKim The relationship between synaptonemal complex formation (synapsis) and double-strand break formation (recombination initiation) differs between organisms. Although double-strand break creation is required for normal...