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Keywords: Dominant-negative isoform
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Journal Articles
J Cell Sci (2001) 114 (22): 4051–4061.
Published: 15 November 2001
... the nuclear translocation of ARNT but not that of endogenous HIF-1α, and was associated with ARNT in the cytosol. These results suggest that HIF-1αZ functions as a dominant-negative isoform of HIF-1 by sequestering ARNT in the cytosol. In addition, the generation of HIF-1αZ seems to be responsible...