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Keywords: Dominant negative
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Journal Articles
J Cell Sci (2007) 120 (22): 4009–4015.
Published: 15 November 2007
... signaling in cancer has not been explored. Here, we identify a small fragment of LRP1 that exhibits high affinity to MK. This fragment inhibits the binding between MK and LRP1, and could therefore be used as a soluble dominant-negative MK receptor. We report here the new finding that MK-LRP1 is crucial...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (17): 3602–3612.
Published: 01 September 2006
... that AE1 R664X protein, which is associated with dominant hereditary spherocytosis, has a dominant-negative effect on the expression of wild-type AE1. To determine whether the R664X mutation has a dominant-negative effect on expression of wild-type AE1, we analyzed the stability and functional...
Includes: Supplementary data
Journal Articles
J Cell Sci (2004) 117 (23): 5591–5597.
Published: 01 November 2004
.... * Author for correspondence (e-mail: vperrier@igh.cnrs.fr ) 21 7 2004 © The Company of Biologists Limited 2004 2004 PrP Prion Dominant negative Lentivirus Therapy Transmissible spongiform encephalopathies (TSEs) are neurodegenerative disorders including Creutzfeldt-Jakob...
Journal Articles
J Cell Sci (2004) 117 (20): 4665–4672.
Published: 15 September 2004
... by which a native connexin, exerting a dominant negative effect, can inhibit gap junctional intercellular communication. In the testis, connexin33 could exert a specific role on germ cell proliferation by suppressing the regulatory effect of connexin43. There is growing evidence that phosphorylation may...