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Keywords: Disaggregation
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Journal Articles
J Cell Sci (2022) 135 (6): jcs258542.
Published: 31 March 2022
... of rabbit reticulocyte lysate (RRL) and/or a combination of Hsc70 and Hsp40 (also known as HSPA8 and DNAJB1, respectively). Targeted deletion mutagenesis revealed that the SBDβ and H domains of Osp94 are critical for protein disaggregation and RRL-mediated refolding. Reactivation of Hsp90-bound heat...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (11): 1917–1926.
Published: 1 June 2009
... by disaggregation. This specific interaction leads not only to mutual detoxification of the pro-apoptotic activity of Omi and Aβ-induced neurotoxicity, but also to a reduction of neurotoxic-Aβ accumulation. The neuroprotective role of Omi is further supported by its upregulation during normal neurogenesis...
Includes: Supplementary data