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Keywords: Differentiation
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Journal Articles
J Cell Sci (2021) 134 (2): jcs247643.
Published: 27 January 2021
... in a water bath ( Fig. 1 A). Control cells were subjected to an identical procedure within a non-pressurized water bath. We then exposed cells to cyclic HP at 1 MPa, 0.3 Hz for 6 h and analyzed the effect on chondrocyte state. Analysis of chondrocyte progenitor and differentiation markers revealed that HP...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (24): jcs245282.
Published: 23 December 2020
... of histone variants and gene position changes with respect to the nuclear periphery. Here, using high-resolution microscopy and quantitative image analysis, we surveyed a panel of histone modifications for changes in nuclear peripheral enrichment during differentiation of human embryonic stem cells...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (24): jcs247841.
Published: 23 December 2020
... mechanistic evidence indicating that ubiquitin carboxyl-terminal hydrolase 8 (USP8) modulates BDNF- and TrkB-dependent neuronal differentiation. USP8 binds to the C-terminus of TrkB using its microtubule-interacting domain (MIT). Immunopurified USP8 deubiquitylates TrkB in vitro , whereas knockdown of USP8...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (17): jcs228015.
Published: 11 September 2020
... in lineage specification, proliferative potential, differentiation, cell death and survival, DNA damage response and metabolism. Furthermore, p63 is linked to human disease states including cancer. p63 is critical to many aspects of cell signaling, and in this Cell science at a glance article...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (17): jcs228973.
Published: 09 September 2019
...Shinji Kondo; Hidemasa Kato; Yutaka Suzuki; Toyoyuki Takada; Masamitsu Eitoku; Toshihiko Shiroishi; Narufumi Suganuma; Sumio Sugano; Hidenori Kiyosawa ABSTRACT We developed an in vitro system to differentiate embryonic stem cells (ESCs) derived from reciprocally crossed F1 hybrid mice into neurons...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (16): jcs230490.
Published: 27 August 2019
.... In line with this, CXCL2 overexpression attenuated proliferation, as well as differentiation, of osteoblasts in vitro . By contrast, CXCL2 downregulation promoted osteoblast expansion and differentiation. Mechanistically, CXCL2 inhibits the ERK1/2 (MAPK3/1) signaling pathway in osteoblasts. Activation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (6): jcs222059.
Published: 18 March 2019
... , in cultured Schwann cells and find that tau is present in these cells. Gene silencing of Mapt promoted Schwann cell proliferation and inhibited Schwann cell migration and differentiation. In vivo application of Mapt siRNA suppressed the migration of Schwann cells after sciatic nerve injury. Consistent...
Journal Articles
In collection:
Polarity
J Cell Sci (2018) 131 (24): jcs219204.
Published: 17 December 2018
... structural variations that result in a remarkable repertoire of diverse compounds. This diversity of GSLs is exploited during embryogenesis, when different GSLs are produced at specific developmental stages and along several differentiation trajectories. Importantly, plasma membrane receptors interact...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (21): 3740–3748.
Published: 01 November 2017
... regulation in neuroendocrine differentiated cells. This point mutation altered the promoter's regulatory mechanism by discrete changes in transcription factor TR occupancy and altered enrichment of the repressive chromatin modification of histone-3-lysine-9-trimethyl (H3K9Me3). Insights relating...
Journal Articles
J Cell Sci (2017) 130 (18): 3083–3093.
Published: 15 September 2017
...Julie Perroud; Laurent Bernheim; Maud Frieden; Stephane Koenig ABSTRACT Ca 2+ signaling plays a key role during human myoblast differentiation. Among Ca 2+ -sensitive pathways, calcineurin is essential for myoblast differentiation and muscle regeneration. Nuclear factor of activated T-cell (NFAT...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (17): 2833–2842.
Published: 01 September 2017
...Julia Lindqvist; Elin Torvaldson; Josef Gullmets; Henok Karvonen; Andras Nagy; Pekka Taimen; John E. Eriksson ABSTRACT Nestin, a member of the cytoskeletal family of intermediate filaments, regulates the onset of myogenic differentiation through bidirectional signaling with the kinase Cdk5. Here...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (14): 2371–2381.
Published: 15 July 2017
...: Fluorescent transgenic reporter constructs detecting caspase activity were designed and integrated in Xenopus embryos, revealing an unexpected nonapoptotic function for the initiator caspase-9 in primitive blood formation. Caspase Apoptosis Erythropoiesis Differentiation Xenopus Cell...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (4): 683–688.
Published: 15 February 2017
...Marta N. Shahbazi; Daniel Peña-Jimenez; Francesca Antonucci; Matthias Drosten; Mirna Perez-Moreno ABSTRACT Epidermal homeostasis is tightly controlled by a balancing act of self-renewal or terminal differentiation of proliferating basal keratinocytes. An increase in DNA content as a consequence...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (19): 3533–3540.
Published: 01 October 2016
...Ksenia G. Kolobynina; Valeria V. Solovyova; Konstantin Levay; Albert A. Rizvanov; Vladlen Z. Slepak ABSTRACT Tescalcin (TESC, also known as calcineurin-homologous protein 3, CHP3) is a 24-kDa EF-hand Ca 2+ -binding protein that has recently emerged as a regulator of cell differentiation and growth...
Journal Articles
J Cell Sci (2016) 129 (4): 788–803.
Published: 15 February 2016
...Christine Hofstetter; Justyna M. Kampka; Sascha Huppertz; Heike Weber; Andreas Schlosser; Albrecht M. Müller; Matthias Becker ABSTRACT Pluripotent embryonic stem cells (ESCs) are characterised by their capacity to self-renew indefinitely while maintaining the potential to differentiate into all...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (1): 145–154.
Published: 01 January 2016
... cells, whereas, during megakaryocytic differentiation, declining Gfi1b levels facilitate a robust induction of Rgs18. Concordantly, alterations in Rgs18 expression produce disparate outcomes by augmenting megakaryocytic and potently suppressing erythroid differentiation and vice versa. These phenotypes...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (23): 4306–4316.
Published: 01 December 2015
...-stromal-cell-derived neuregulin-1 induces ErbB2–ErbB3 heterodimerization in extravillous trophoblasts and stabilizes trophoblast differentiation through suppression of apoptosis. Trophoblast Neuregulin 1 ErbB2 ErbB3 Apoptosis Differentiation Neuregulin 1 (NRG1) is widely known to play...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (14): 2415–2422.
Published: 15 July 2015
...Pan Dan; Émilie Velot; Véronique Decot; Patrick Menu ABSTRACT Mesenchymal stem cells (MSCs) are among the most promising and suitable stem cell types for vascular tissue engineering. Substantial effort has been made to differentiate MSCs towards vascular cell phenotypes, including endothelial cells...
Journal Articles
J Cell Sci (2015) 128 (9): 1707–1717.
Published: 01 May 2015
...Genevieve S. Griffiths; Jinger Doe; Mayumi Jijiwa; Pam Van Ry; Vivian Cruz; Michelle de la Vega; Joe W. Ramos; Dean J. Burkin; Michelle L. Matter Muscle differentiation requires a complex signaling cascade that leads to the production of multinucleated myofibers. Genes regulating the intrinsic...
Journal Articles
J Cell Sci (2014) 127 (24): 5261–5272.
Published: 15 December 2014
...Takashi Nakamura; Yasuo Yoshitomi; Kiyoshi Sakai; Vyomesh Patel; Satoshi Fukumoto; Yoshihiko Yamada ABSTRACT The basal layer of the epidermis contains stem cells and transit amplifying cells that rapidly proliferate and differentiate further into the upper layers of the epidermis. A number...
Includes: Supplementary data