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Keywords: Dictyostelium
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Journal Articles
J Cell Sci (2021) 134 (14): jcs258777.
Published: 22 July 2021
...Shigenori Hirose; Mariko Katoh-Kurasawa; Gad Shaulsky ABSTRACT Allorecognition and tissue formation are interconnected processes that require signaling between matching pairs of the polymorphic transmembrane proteins TgrB1 and TgrC1 in Dictyostelium . Extracellular and intracellular cAMP signaling...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (22): jcs236505.
Published: 14 November 2019
... distinct, but conserved, glycine residues in both the Dictyostelium piaA gene and its human ortholog, RICTOR . The two conserved residues are spaced ∼50 amino acids apart, and both are embedded within a conserved region falling in between the Ras-GEFN2 and Rictor­_V domains. The effects of point mutations...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (2): jcs224998.
Published: 24 January 2019
...Thomas D. Williams; Sew-Yeu Peak-Chew; Peggy Paschke; Robert R. Kay ABSTRACT Macropinocytosis is an actin-driven process of large-scale and non-specific fluid uptake used for feeding by some cancer cells and the macropinocytosis model organism Dictyostelium discoideum . In Dictyostelium...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (23): jcs222000.
Published: 30 November 2018
... of reactive oxygen species, deprivation of nutrients and the lumenal accumulation of toxic metals are essential to kill ingested bacteria or inhibit the growth of intracellular pathogens. Here, we used the soil amoeba Dictyostelium discoideum , a professional phagocyte that digests bacteria for nutritional...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (19): jcs207951.
Published: 11 October 2018
...Lauriane Mas; Adeline Cieren; Christian Delphin; Agnès Journet; Laurence Aubry ABSTRACT Arrestins are key adaptor proteins that control the fate of cell-surface membrane proteins and modulate downstream signaling cascades. The Dictyostelium discoideum genome encodes six arrestin-related proteins...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2018) 131 (9): jcs216176.
Published: 04 May 2018
...Weiye Wang; Song Chen; Satarupa Das; Wolfgang Losert; Carole A. Parent ABSTRACT Dictyostelium discoideum cells transport adenylyl cyclase A (ACA)-containing vesicles to the back of polarized cells to relay exogenous cAMP signals during chemotaxis. Fluorescence in situ hybridization (FISH...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (7): jcs208892.
Published: 09 April 2018
...-proteins and the cytoskeleton. Small G-proteins Cytoskeleton Symmetry Dictyostelium Chemotaxis All data shown are the mean±s.d. or s.e.m. with the number of replicates ( n ) as indicated in the figure legends or text. Statistical significance was tested with a Student's t -test...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (6): jcs213736.
Published: 21 March 2018
...Thomas D. Williams; Robert R. Kay ABSTRACT Macropinocytosis is a conserved endocytic process used by Dictyostelium amoebae for feeding on liquid medium. To further Dictyostelium as a model for macropinocytosis, we developed a high-throughput flow cytometry assay to measure macropinocytosis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (23): 4002–4012.
Published: 01 December 2017
...Shigenori Hirose; Gong Chen; Adam Kuspa; Gad Shaulsky ABSTRACT Allorecognition is a key factor in Dictyostelium development and sociality. It is mediated by two polymorphic transmembrane proteins, TgrB1 and TgrC1, which contain extracellular immunoglobulin domains. TgrB1 and TgrC1 are necessary...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (14): 2394–2404.
Published: 15 July 2017
...Patrick M. Suess; Jacob Watson; Wensheng Chen; Richard H. Gomer ABSTRACT Linear chains of five to hundreds of phosphates called polyphosphate are found in organisms ranging from bacteria to humans, but their function is poorly understood. In Dictyostelium discoideum , polyphosphate is used...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (10): 1785–1795.
Published: 15 May 2017
...Peter A. Thomason; Jason S. King; Robert H. Insall ABSTRACT The steps leading to constitutive exocytosis are poorly understood. In Dictyostelium WASH complex mutants, exocytosis is blocked, so cells that take up fluorescent dextran from the medium retain it and remain fluorescent. Here, we...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (3): 551–562.
Published: 01 February 2017
...Barbara Pergolizzi; Enrico Bracco; Salvatore Bozzaro ABSTRACT Cyclic AMP (cAMP) binding to G-protein-coupled receptors (GPCRs) orchestrates chemotaxis and development in Dictyostelium. By activating the RasC–TORC2–PKB (PKB is also known as AKT in mammals) module, cAMP regulates cell polarization...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (24): 4449–4454.
Published: 15 December 2016
.... Food is a common source of mutagens, but little is known about how nutritional factors cause lasting genetic changes in the consuming organism. Here, we describe an unusual genetic interaction between DNA repair in the unicellular amoeba Dictyostelium discoideum and its natural bacterial food source...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (20): 3845–3858.
Published: 15 October 2016
... by promoting enrichment of repair factors at damage sites through ADP-ribose interaction domains. Here, we exploit the simple eukaryote Dictyostelium to uncover a role for ADP-ribosylation in regulating DNA interstrand crosslink repair and redundancy of this pathway with non-homologous end-joining (NHEJ...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (8): 1722–1733.
Published: 15 April 2016
...Mariko Katoh-Kurasawa; Balaji Santhanam; Gad Shaulsky ABSTRACT The GATA transcription factor GtaG is conserved in Dictyostelids and is essential for terminal differentiation in Dictyostelium discoideum , but its function is not well understood. Here, we show that gtaG is expressed in prestalk cells...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (21): 3990–3996.
Published: 01 November 2015
...Cheng-Lin Frank Li; Gong Chen; Amanda Nicole Webb; Gad Shaulsky ABSTRACT Cell surface adhesion receptors play diverse functions in multicellular development. In Dictyostelium , two immunoglobulin-like adhesion proteins, TgrB1 and TgrC1, are essential components with dual roles in morphogenesis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (23): 5115–5125.
Published: 01 December 2014
... of differentiated Dictyostelium discoideum cells to investigate whether localized receptor stimuli can induce the spreading of excitable waves in the G-protein-dependent signal transduction system. By imaging the spatiotemporal dynamics of fluorescent markers for phosphatidylinositol (3,4,5)-trisphosphate (PIP 3...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (7): 1576–1584.
Published: 01 April 2014
... both proteolysis-dependent functions, as components of the γ-secretase complex, and proteolysis-independent functions in signalling. In this study, we investigate a conserved function of human presenilins in the development of the simple model organism Dictyostelium discoideum . We show that the block...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (23): 5465–5476.
Published: 01 December 2013
...Steven Robery; Richard Tyson; Christopher Dinh; Adam Kuspa; Angelika A. Noegel; Till Bretschneider; Paul L. R. Andrews; Robin S. B. Williams Summary Detection of substances tasting bitter to humans occurs in diverse organisms including the social amoeba Dictyostelium discoideum . To establish...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (22): 5247–5258.
Published: 15 November 2013
...Hiroshi Senoo; Tsuyoshi Araki; Masashi Fukuzawa; Jeffrey G. Williams Summary MrfA, a transcription factor that regulates Dictyostelium prestalk cell differentiation, is an orthologue of the metazoan myelin gene regulatory factor (MRF) proteins. We show that the MRFs contain a predicted...