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Keywords: Dictyostelium
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Journal Articles
J Cell Sci (2023) 136 (20): jcs261447.
Published: 16 October 2023
... light on both the regulation and function of atypical MAPKs in different organisms. In particular, the analysis of the atypical MAPK in the amoeba Dictyostelium discoideum has revealed important roles in chemotactic responses and gene regulation. The rapid and transient phosphorylation of the atypical...
Journal Articles
In collection:
Cell migration
J Cell Sci (2023) 136 (3): jcs260591.
Published: 2 February 2023
...Shigehiko Yumura; Masaki Nakano; Aika Honda; Yuuki Hashimoto; Tomo Kondo ABSTRACT Cyclic guanosine 3′,5′-monophosphate (cGMP) is a ubiquitous important second messenger involved in various physiological functions. Here, intracellular cGMP (cGMPi) was visualized in chemotactic Dictyostelium cells...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (18): jcs260107.
Published: 21 September 2022
...Ramesh Rijal; Sara A. Kirolos; Ryan J. Rahman; Richard H. Gomer ABSTRACT Dictyostelium discoideum is a unicellular eukaryote that eats bacteria, and eventually outgrows the bacteria. D. discoideum cells accumulate extracellular polyphosphate (polyP), and the polyP concentration increases...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (16): jcs260148.
Published: 19 August 2022
...Jeffrey A. Hadwiger; Huaqing Cai; Ramee G. Aranda; Saher Fatima ABSTRACT The Dictyostelium atypical mitogen-activated protein kinase (MAPK) Erk2 is required for chemotactic responses to cAMP as amoeba undergo multicellular development. In this study, Erk2 was found to be essential for the cAMP...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (7): jcs259648.
Published: 14 April 2022
...Günther Gerisch; Jana Prassler; Mary Ecke ABSTRACT In multi-nucleate cells of Dictyostelium , cytokinesis is performed by unilateral cleavage furrows that ingress the large cells from their border. We use a septase (sepA)-null mutant with delayed cytokinesis to show that in anaphase a pattern...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2021) 134 (14): jcs258777.
Published: 22 July 2021
...Shigenori Hirose; Mariko Katoh-Kurasawa; Gad Shaulsky ABSTRACT Allorecognition and tissue formation are interconnected processes that require signaling between matching pairs of the polymorphic transmembrane proteins TgrB1 and TgrC1 in Dictyostelium . Extracellular and intracellular cAMP signaling...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2019) 132 (2): jcs224998.
Published: 24 January 2019
...Thomas D. Williams; Sew-Yeu Peak-Chew; Peggy Paschke; Robert R. Kay ABSTRACT Macropinocytosis is an actin-driven process of large-scale and non-specific fluid uptake used for feeding by some cancer cells and the macropinocytosis model organism Dictyostelium discoideum . In Dictyostelium...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
In collection:
Imaging
J Cell Sci (2018) 131 (9): jcs216176.
Published: 4 May 2018
...Weiye Wang; Song Chen; Satarupa Das; Wolfgang Losert; Carole A. Parent ABSTRACT Dictyostelium discoideum cells transport adenylyl cyclase A (ACA)-containing vesicles to the back of polarized cells to relay exogenous cAMP signals during chemotaxis. Fluorescence in situ hybridization (FISH...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (7): jcs208892.
Published: 9 April 2018
...-proteins and the cytoskeleton. Small G-proteins Cytoskeleton Symmetry Dictyostelium Chemotaxis The nature of physics is symmetrical. For instance, molecules have equal probability to diffuse to the right or left ( Livio, 2012 ; Gross, 1996 ). Cells and organisms appear approximately...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (6): jcs213736.
Published: 21 March 2018
...Thomas D. Williams; Robert R. Kay ABSTRACT Macropinocytosis is a conserved endocytic process used by Dictyostelium amoebae for feeding on liquid medium. To further Dictyostelium as a model for macropinocytosis, we developed a high-throughput flow cytometry assay to measure macropinocytosis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (23): 4002–4012.
Published: 1 December 2017
...Shigenori Hirose; Gong Chen; Adam Kuspa; Gad Shaulsky ABSTRACT Allorecognition is a key factor in Dictyostelium development and sociality. It is mediated by two polymorphic transmembrane proteins, TgrB1 and TgrC1, which contain extracellular immunoglobulin domains. TgrB1 and TgrC1 are necessary...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (14): 2394–2404.
Published: 15 July 2017
...Patrick M. Suess; Jacob Watson; Wensheng Chen; Richard H. Gomer ABSTRACT Linear chains of five to hundreds of phosphates called polyphosphate are found in organisms ranging from bacteria to humans, but their function is poorly understood. In Dictyostelium discoideum , polyphosphate is used...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (10): 1785–1795.
Published: 15 May 2017
...Peter A. Thomason; Jason S. King; Robert H. Insall ABSTRACT The steps leading to constitutive exocytosis are poorly understood. In Dictyostelium WASH complex mutants, exocytosis is blocked, so cells that take up fluorescent dextran from the medium retain it and remain fluorescent. Here, we...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (3): 551–562.
Published: 1 February 2017
...Barbara Pergolizzi; Enrico Bracco; Salvatore Bozzaro ABSTRACT Cyclic AMP (cAMP) binding to G-protein-coupled receptors (GPCRs) orchestrates chemotaxis and development in Dictyostelium. By activating the RasC–TORC2–PKB (PKB is also known as AKT in mammals) module, cAMP regulates cell polarization...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (24): 4449–4454.
Published: 15 December 2016
.... Food is a common source of mutagens, but little is known about how nutritional factors cause lasting genetic changes in the consuming organism. Here, we describe an unusual genetic interaction between DNA repair in the unicellular amoeba Dictyostelium discoideum and its natural bacterial food source...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (20): 3845–3858.
Published: 15 October 2016
... by promoting enrichment of repair factors at damage sites through ADP-ribose interaction domains. Here, we exploit the simple eukaryote Dictyostelium to uncover a role for ADP-ribosylation in regulating DNA interstrand crosslink repair and redundancy of this pathway with non-homologous end-joining (NHEJ...
Includes: Supplementary data