... the blood–brain barrier (BBB) is a critical step in central nervous system (CNS) immune surveillance and inflammation. Whereas T cell diapedesis across the intact BBB seems to occur preferentially through the BBB cellular junctions, impaired BBB integrity during neuroinflammation is accompanied by increased...

.... Highlighted Article: Neutrophil L-selectin co-clusters with PECAM-1 in cis during transendothelial migration (TEM). Clustering neutrophil PECAM-1 activates p38 MAPK and JNK to regulate L-selectin shedding, which in turn expedites TEM. PECAM-1 Diapedesis Transmigration p38 MAPK JNK...

...Christopher V. Carman Immune-system functions require that blood leukocytes continuously traffic throughout the body and repeatedly cross endothelial barriers (i.e. diapedese) as they enter (intravasate) and exit (extravasate) the circulation. The very earliest studies to characterize diapedesis...

... membrane during neutrophil diapedesis in an in vitro construct of a blood vessel wall . J. Clin. Invest . 83 , 1122 – 1136 . 10.1172/JCI113992 Hughes , B. J. , Hollers , J. C. , Crockett-Torabi , E. and Smith , C. W. ( 1992 ). Recruitment of CD11b/CD18 to the neutrophil...

...Martin Sandig; Ella Negrou; Kem A. Rogers ABSTRACT To determine changes in the spatial and temporal distribution of cell-cell adhesion molecules during transendo-thelial migration of monocytes, we examined an in vitro model system of diapedesis using high resolution laser scanning confocal...