...Kayla F. Titialii-Torres; Ann C. Morris ABSTRACT Diabetes is linked to various long-term complications in adults, such as neuropathy, nephropathy and diabetic retinopathy. Diabetes poses additional risks for pregnant women, because glucose passes across the placenta, and excess maternal glucose can...

... ). Diabetes and atherosclerosis: epidemiology, pathophysiology, and management . JAMA 287 , 2570 - 2581 . 10.1001/jama.287.19.2570 Böttcher , R. T. , Wiesner , S. , Braun , A. , Wimmer , R. , Berna , A. , Elad , N. , Medalia , O. , Pfeifer , A. , Aszódi...

... investigated how topical insulin application would affect the diabetic wound healing process. We found that the excessive expression of insulin-degrading enzyme led to insufficient insulin levels in diabetic skin during wound healing, which ultimately reduced the recovery rate of diabetic wounds. We confirmed...

...Samuel M. Bestall; Richard P. Hulse; Zoe Blackley; Matthew Swift; Nikita Ved; Kenneth Paton; Nicholas Beazley-Long; David O. Bates; Lucy F. Donaldson ABSTRACT Many potential causes for painful diabetic neuropathy have been proposed including actions of cytokines and growth factors. High mobility...

... exocytosis. Small GTPase Secretory granule Regulated exocytosis Insulin Pancreatic β-cell Diabetes Regulated secretion is a main pathway in the delivery of the bioactive molecules of a cell to the extracellular environment. The pathway comprises coordinated sequential steps...

... . Bonner-Weir , S. ( 1988 ). Morphological evidence for pancreatic polarity of beta cell within islets of Langerhans . Diabetes   37 , 616 - 621 . 10.2337/diab.37.5.616 Bryant , D. M. , Datta , A. , Rodriguez-Fraticelli , A. E. , Peränen , J. , Martín-Belmonte , F...

...Ge Li; Binlin Wu; Meliza G. Ward; Angie C. N. Chong; Sushmita Mukherjee; Shuibing Chen; Mingming Hao ABSTRACT Pancreatic islet dysfunction leading to insufficient glucose-stimulated insulin secretion triggers the clinical onset of diabetes. How islet dysfunction develops is not well understood...

...Yi Wang; Chengsheng Han; Wenzhen Zhu; Zhengxing Wu; Yanmei Liu; Liangyi Chen ABSTRACT Imbalanced glucagon and insulin release leads to the onset of type 2 diabetes. To pinpoint the underlying primary driving force, here we have developed a fast, non-biased optical method to measure ratios...

... PI3K and induces endocytosis through promoting signaling crosstalk between Arf6 and Rab27a pathways. Endocytosis Small GTPase Insulin Membrane trafficking Diabetes Pancreatic β-cells Bidirectional intracellular trafficking is fundamental to maintain cellular homeostasis. In secretory...

... stress in diabetes mellitus. Endocr. Rev. 29 , 42 -61. Ellenberg, J., Siggia, E. D., Moreira, J. E., Smith, C. L., Presley, J. F., Worman, H. J. and Lippincott-Schwartz, J. ( 1997 ). Nuclear membrane dynamics and reassembly in living cells: targeting of an inner nuclear membrane protein...

... by lipid dephosphorylation at the plasma membrane, PTEN also resides in the cytoplasm and nucleus, and its subcellular distribution is under strict control. Deregulation of PTEN function is implicated in other human diseases in addition to cancer, including diabetes and autism. References Agrawal, S...

... outside the mammalian pancreas has implications for regenerative medicine, indicating that biliary epithelium might offer a new source of β cells for the treatment of diabetes. The finding also has evolutionary significance, because it is known that certain basal vertebrates usually form all of their β...

... of apoptosis and/or calcium homeostasis. Presenilin 2 mRNA is expressed in brain, muscle and pancreas but the role of pancreatic presenilin 2 and its relationship to diabetes are unknown. Presenilin 2 immunoreactivity was localised in human and rodent pancreas to islet cells and found in granules of β-cells...