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Keywords: Desmosome
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Journal Articles
J Cell Sci jcs.258906.
Published: 12 October 2021
...Judith B. Fülle; Henri Huppert; David Liebl; Jaron Liu; Rogerio Alves de Almeida; Bian Yanes; Graham D. Wright; E. Birgitte Lane; David R. Garrod; Christoph Ballestrem Desmosomes, strong cell-cell junctions of epithelia and cardiac muscle, link intermediate filaments to cell membranes...
Journal Articles
J Cell Sci (2020) 133 (6): jcs228031.
Published: 16 March 2020
... junctions, desmosomes. We provide evidence that this system not only ensures tissue integrity, but also cooperates with other networks to create more complex tissues with emerging properties in sensing and responding to increasingly stressful environments. We will also draw attention to how defects...
Journal Articles
J Cell Sci (2014) 127 (17): 3782–3793.
Published: 01 September 2014
...Brett J. Roberts; Kristen E. Johnson; Kathleen P. McGuinn; Jintana Saowapa; Robert A. Svoboda; My G. Mahoney; Keith R. Johnson; James K. Wahl, III ABSTRACT Desmosomes are prominent adhesive junctions found in various epithelial tissues. The cytoplasmic domains of desmosomal cadherins interact...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (10): 2339–2350.
Published: 15 May 2014
...Molly Lowndes; Sabyasachi Rakshit; Omer Shafraz; Nicolas Borghi; Robert M. Harmon; Kathleen J. Green; Sanjeevi Sivasankar; W. James Nelson ABSTRACT Adhesion between cells is established by the formation of specialized intercellular junctional complexes, such as desmosomes. Desmosomes contain...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (10): 2174–2188.
Published: 15 May 2014
...-Seetharam; Sorab N. Dalal ABSTRACT The regulation of cell–cell adhesion is important for the processes of tissue formation and morphogenesis. Here, we report that loss of 14-3-3γ leads to a decrease in cell–cell adhesion and a defect in the transport of plakoglobin and other desmosomal proteins to the cell...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (12): 2853–2861.
Published: 15 June 2012
...Rita M. Cabral; Daniel Tattersall; Vishal Patel; Graham D. McPhail; Elizabeth Hatzimasoura; Dominic J. Abrams; Andrew P. South; David P. Kelsell Summary Desmosomes are intercellular junctions specialised for strong adhesion that are prominent in the epidermis and heart muscle. Defective desmosomal...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (4): 1058–1067.
Published: 15 February 2012
... complexes: adherens junctions, desmosomes and gap junctions. However, recent morphological and molecular data indicate a mixing of adherens junctional and desmosomal components, resulting in a ‘hybrid adhering junction’ or ‘area composita’. The α-catenin family member αT-catenin, part of the N-cadherin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (20): 3576–3586.
Published: 15 October 2010
.... , Stokes D. L. ( 2008 ). Plakoglobin is required for effective intermediate filament anchorage to desmosomes . J. Invest. Dermatol. 128 , 2665 - 2675 . Aktary Z. , Chapman K. , Lam L. , Lo A. , Ji C. , Graham K. , Cook L. , Li L. , Mackey J. R...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2009) 122 (15): 2699–2709.
Published: 01 August 2009
...Emilie A. Leclerc; Anne Huchenq; Nicolas R. Mattiuzzo; Daniel Metzger; Pierre Chambon; Norbert B. Ghyselinck; Guy Serre; Nathalie Jonca; Marina Guerrin Corneodesmosin (CDSN) is specific to desmosomes of epithelia undergoing cornification, mainly the epidermis and the inner root sheath of the hair...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (12): 2126–2136.
Published: 15 June 2007
... microscopy, that desmosomal proteins in the heart localize not only to the desmosomes in the intercalated discs but also at adhering junctions with hybrid composition. We found that in the latter junctions, endogenous plakophilin-2 colocalizes with αT-catenin. By providing an extra link between the cadherin...
Journal Articles
J Cell Sci (2006) 119 (5): 797–806.
Published: 01 March 2006
... in these diseases has led to significant increases in our understanding of intermediate filament biology. The major cell-surface attachment site for intermediate filament networks is the desmosome, an adhesive intercellular junction prominent in the epidermis and the heart. During the past decade, substantial...
Journal Articles
J Cell Sci (2006) 119 (3): 482–489.
Published: 01 February 2006
...Zhining Den; Xing Cheng; Maria Merched-Sauvage; Peter J. Koch Desmocollin 3 (Dsc3) is a transmembrane glycoprotein that belongs to the cadherin family of cell adhesion receptors. Together with desmoglein(s), it forms the transmembrane core of desmosomes, a multiprotein complex involved in cell...
Includes: Supplementary data
Journal Articles
J Cell Sci (2005) 118 (24): 5743–5754.
Published: 15 December 2005
...David R. Garrod; Mohamed Y. Berika; William F. Bardsley; David Holmes; Lydia Tabernero The resistance of tissues to physical stress is dependent upon strong cell-cell adhesion in which desmosomes play a crucial role. We propose that desmosomes fulfil this function by adopting a more strongly...
Journal Articles
J Cell Sci (2003) 116 (7): 1219–1233.
Published: 01 April 2003
...Mechthild Hatzfeld; Kathleen J. Green; Helmut Sauter p0071, a member of the armadillo protein family, is most closely related to p120 ctn and the plakophilins 1-3. Whereas plakophilins are desmosomal plaque proteins, p120 ctn localizes to adherens junctions and interacts with classical cadherins...
Journal Articles
J Cell Sci (2003) 116 (5): 875–885.
Published: 01 March 2003
...David E. Gutstein; Fang-yu Liu; Marian B. Meyers; Andrew Choo; Glenn I. Fishman Adherens junctions and desmosomes are responsible for mechanically coupling myocytes in the heart and are found closely apposed to gap junction plaques at the intercalated discs of cardiomyocytes. It is not known...
Journal Articles
J Cell Sci (2002) 115 (8): 1717–1732.
Published: 15 April 2002
...Reinhard Windoffer; Monika Borchert-Stuhlträger; Rudolf E. Leube Desmosomes are prominent cell adhesion structures that are major stabilizing elements, together with the attached cytoskeletal intermediate filament network, of the cytokeratin type in epithelial tissues. To examine desmosome...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (1993) 1993 (Supplement_17): 119–125.
Published: 01 December 1993
.... Trophectoderm differentiation begins at compaction (8-cell stage) when cell-cell adhesion, mediated by uvomorulin, and epithelial cell polarisation first occur. Here, we review our work on the biogenesis of tight junctions and desmosomes during epithelial differentiation. Tight junction construction begins...