...Hua Li; Yinzhen He; Yan Wang; Lin Xie; Gangyun Wu; Xiayu Liu; Xiufen Duan; Kaiyao Zhou; Wenxiu Ning ABSTRACT Desmosomes play a crucial role in maintaining tissue barrier integrity, particularly in mechanically stressed tissues. The assembly of desmosomes is regulated by the cytoskeleton and its...

...Judith B. Fülle; Henri Huppert; David Liebl; Jaron Liu; Rogerio Alves de Almeida; Bian Yanes; Graham D. Wright; E. Birgitte Lane; David R. Garrod; Christoph Ballestrem ABSTRACT Desmosomes, strong cell–cell junctions of epithelia and cardiac muscle, link intermediate filaments to cell membranes...

... junctions, desmosomes. We provide evidence that this system not only ensures tissue integrity, but also cooperates with other networks to create more complex tissues with emerging properties in sensing and responding to increasingly stressful environments. We will also draw attention to how defects...

...Brett J. Roberts; Kristen E. Johnson; Kathleen P. McGuinn; Jintana Saowapa; Robert A. Svoboda; My G. Mahoney; Keith R. Johnson; James K. Wahl, III ABSTRACT Desmosomes are prominent adhesive junctions found in various epithelial tissues. The cytoplasmic domains of desmosomal cadherins interact...

...Molly Lowndes; Sabyasachi Rakshit; Omer Shafraz; Nicolas Borghi; Robert M. Harmon; Kathleen J. Green; Sanjeevi Sivasankar; W. James Nelson ABSTRACT Adhesion between cells is established by the formation of specialized intercellular junctional complexes, such as desmosomes. Desmosomes contain...

...-Seetharam; Sorab N. Dalal ABSTRACT The regulation of cell–cell adhesion is important for the processes of tissue formation and morphogenesis. Here, we report that loss of 14-3-3γ leads to a decrease in cell–cell adhesion and a defect in the transport of plakoglobin and other desmosomal proteins to the cell...

...Rita M. Cabral; Daniel Tattersall; Vishal Patel; Graham D. McPhail; Elizabeth Hatzimasoura; Dominic J. Abrams; Andrew P. South; David P. Kelsell Summary Desmosomes are intercellular junctions specialised for strong adhesion that are prominent in the epidermis and heart muscle. Defective desmosomal...

... complexes: adherens junctions, desmosomes and gap junctions. However, recent morphological and molecular data indicate a mixing of adherens junctional and desmosomal components, resulting in a ‘hybrid adhering junction’ or ‘area composita’. The α-catenin family member αT-catenin, part of the N-cadherin...

... Desmosome Extracellular matrix Keratinocyte Epithelial tissues derive positional and functional cues from their surroundings, in part through cell–cell and cell–substrate interactions involving cadherins and integrins, respectively ( Hynes, 2002 ; Wheelock and Johnson, 2003 ). Adhesion-dependent...

...Emilie A. Leclerc; Anne Huchenq; Nicolas R. Mattiuzzo; Daniel Metzger; Pierre Chambon; Norbert B. Ghyselinck; Guy Serre; Nathalie Jonca; Marina Guerrin Corneodesmosin (CDSN) is specific to desmosomes of epithelia undergoing cornification, mainly the epidermis and the inner root sheath of the hair...

... microscopy, that desmosomal proteins in the heart localize not only to the desmosomes in the intercalated discs but also at adhering junctions with hybrid composition. We found that in the latter junctions, endogenous plakophilin-2 colocalizes with αT-catenin. By providing an extra link between the cadherin...

... in these diseases has led to significant increases in our understanding of intermediate filament biology. The major cell-surface attachment site for intermediate filament networks is the desmosome, an adhesive intercellular junction prominent in the epidermis and the heart. During the past decade, substantial...

...Zhining Den; Xing Cheng; Maria Merched-Sauvage; Peter J. Koch Desmocollin 3 (Dsc3) is a transmembrane glycoprotein that belongs to the cadherin family of cell adhesion receptors. Together with desmoglein(s), it forms the transmembrane core of desmosomes, a multiprotein complex involved in cell...

...David R. Garrod; Mohamed Y. Berika; William F. Bardsley; David Holmes; Lydia Tabernero The resistance of tissues to physical stress is dependent upon strong cell-cell adhesion in which desmosomes play a crucial role. We propose that desmosomes fulfil this function by adopting a more strongly...

...Mechthild Hatzfeld; Kathleen J. Green; Helmut Sauter p0071, a member of the armadillo protein family, is most closely related to p120 ctn and the plakophilins 1-3. Whereas plakophilins are desmosomal plaque proteins, p120 ctn localizes to adherens junctions and interacts with classical cadherins...

...David E. Gutstein; Fang-yu Liu; Marian B. Meyers; Andrew Choo; Glenn I. Fishman Adherens junctions and desmosomes are responsible for mechanically coupling myocytes in the heart and are found closely apposed to gap junction plaques at the intercalated discs of cardiomyocytes. It is not known...

...Reinhard Windoffer; Monika Borchert-Stuhlträger; Rudolf E. Leube Desmosomes are prominent cell adhesion structures that are major stabilizing elements, together with the attached cytoskeletal intermediate filament network, of the cytokeratin type in epithelial tissues. To examine desmosome...

..., α-catenin, β-catenin, plakoglobin) and desmosomal (desmoplakin-1/2, plakoglobin) proteins on, and within, cell extensions demonstrating that cell junctions had undergone considerable disassembly. However, groups of cell extensions appeared to be associated by E-cadherin/ catenin-mediated...

...Elayne A. Bornslaeger; Lisa M. Godsel; Connie M. Corcoran; Jung K. Park; Mechthild Hatzfeld; Andrew P. Kowalczyk; Kathleen J. Green ABSTRACT Desmosomes are adhesive junctions that link intermediate filament networks to sites of strong intercellular adhesion. These junctions play an important role...

... a remarkable dual location: they occur in the nuclei of cells and, in epithelial cells, at the plasma membrane within the desmosomal plaques. We have shown by solid phasebinding assays that both PKP1a and PKP2a bind to intermediate filament (IF) proteins, in particular to cytokeratins (CKs) from epidermal...