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1-11 of 11
Keywords: Desmoplakin
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Journal Articles
Rita M. Cabral, Daniel Tattersall, Vishal Patel, Graham D. McPhail, Elizabeth Hatzimasoura, Dominic J. Abrams, Andrew P. South, David P. Kelsell
Journal:
Journal of Cell Science
J Cell Sci (2012) 125 (12): 2853–2861.
Published: 15 June 2012
... function due to inherited mutations in the constitutive desmosomal gene desmoplakin ( DSP ) causes skin or heart disorders and in some instances both. Different mutations have different disease-causing molecular mechanisms as evidenced by the varying phenotypes resulting from mutations affecting different...
Includes: Supplementary data
Journal Articles
Karine Lapouge, Lionel Fontao, Marie-France Champliaud, Fabienne Jaunin, Miguel A. Frias, Bertrand Favre, Denise Paulin, Kathleen J. Green, Luca Borradori
Journal:
Journal of Cell Science
J Cell Sci (2006) 119 (23): 4974–4985.
Published: 1 December 2006
... muscle cells. The desmosomal component desmoplakin plays a key role in tethering various intermediate filament networks through its C-terminal plakin repeat domain. To gain better insight into the cytoskeletal organization of cardiomyocytes, we investigated the association of desmoplakin with desmin...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2004) 117 (15): 3129–3140.
Published: 1 July 2004
...Xuan Zhou; August Stuart; Luis E. Dettin; Gisela Rodriguez; Bonnie Hoel; G. Ian Gallicano Desmoplakin (DP) is a key component of cellular adhesion junctions known as desmosomes; however, recent investigations have revealed a novel location for DP in junctions separate from desmosomes termed...
Journal Articles
Hong Wan, Michael G. Stone, Cathy Simpson, Louise E. Reynolds, John F. Marshall, Ian R. Hart, Kairbaan M. Hodivala-Dilke, Robin A. J. Eady
Journal:
Journal of Cell Science
J Cell Sci (2003) 116 (20): 4239–4248.
Published: 15 October 2003
... populations is worth exploring. Here we report, for the first time, that clusters of basal keratinocytes at the tips of the rete ridges in human palm, previously recognised as a major repository of stem cells, had very low levels of desmoplakin protein and mRNA expression, compared with cells at the sides...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2003) 116 (5): 875–885.
Published: 1 March 2003
... of desmosomes in cardiac myocytes in the absence of Cx43, we double stained for Cx43 and desmoplakin, a necessary component of desmosomes ( Fig. 4 ). As seen with adherens-junction-associated cadherin staining,gap junctions and desmosomes were often juxtaposed at the intercalated disc( Fig. 4E ). However...
Journal Articles
Elayne A. Bornslaeger, Lisa M. Godsel, Connie M. Corcoran, Jung K. Park, Mechthild Hatzfeld, Andrew P. Kowalczyk, Kathleen J. Green
Journal:
Journal of Cell Science
J Cell Sci (2001) 114 (4): 727–738.
Published: 15 February 2001
... demonstrate the existence of a Triton-soluble complex of proteins containing full length desmoplakin (DP), the arm protein plakoglobin, and the cytoplasmic domain of the desmosomal cadherin, desmoglein 1 (Dsg1). In addition, full length DP, but not an N-terminal plakoglobin binding domain of DP, co...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2000) 113 (13): 2471–2483.
Published: 1 July 2000
... complexes containing PKP1a and desmoplakin I (DPI) have been identified by coimmunoprecipitation and sucrose density fractionation. The significance of these interactions of PKP1a with IF proteins on the one hand and desmoplakin on the other is discussed in relation to the fact that PKP1a is not bound...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (1997) 110 (1): 23–33.
Published: 1 January 1997
... is disruption of desmoplakin organization at the cell surface, indicating dissociation of desmosomes. This effect is followed by a dramatic reorganization of both the intermediate filament (keratins 8 and 18) and microfilament networks, resulting in a merged structure in which the intermediate filaments...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (1996) 109 (8): 2141–2149.
Published: 1 August 1996
...Odile Valiron; Véronique Chevrier; Yves Usson; Ferruccio Breviario; Didier Job; Elisabetta Dejana ABSTRACT Desmoplakin is an intracellular component of desmosomes which plays a role in the anchorage of intermediate filaments to these structures. We report here that, despite the absence...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (1990) 97 (2): 247–257.
Published: 1 October 1990
...Bright D. Angst; Laura A. Nilles; Kathleen J. Green ABSTRACT Desmosomes are major intercellular junctions found in association with intermediate filaments in epithelial, cardiac and arachnoidal tissue. Desmoplakins I and II (DPI and II) are highly related proteins localized in the innermost part...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (1986) 86 (1): 233–248.
Published: 1 December 1986
... and antibodies to desmoplakin and vinculin were used as markers for the presence of desmosomes and fasciae adherentes, respectively. Tiny punctate desmosomes were observed between muscle cells after 24 h and apparently increased in number and/or size between 24 and 48 h in culture. Fasciae adherentes were...