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Keywords: Degradation
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Journal Articles
J Cell Sci (2024) 137 (4): jcs261579.
Published: 28 February 2024
... CP110 CCP110 Degradation Proteasome Ubiquitylation National Institute of General Medical Sciences http://dx.doi.org/10.13039/100000057 R35GM144102 Dutch fabric merchant and exemplary microscopy pioneer Antonie van Leeuwenhoek described microorganisms with flagella, otherwise...
Journal Articles
In collection:
Proteostasis
J Cell Sci (2020) 133 (21): jcs249862.
Published: 3 November 2020
... distinct chaperone that forms a tripartite complex with PBAC1 and PBAC2 to promote assembly of the 20S proteasome α-ring in Arabidopsis . Arabidopsis Chaperone Core protease Degradation Evolution Proteasome Proteolysis Proteostasis Regulatory particle Ubiquitin National...
Includes: Supplementary data
Journal Articles
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Autophagy
J Cell Sci (2018) 131 (19): jcs214304.
Published: 4 October 2018
...Alberto Danieli; Sascha Martens ABSTRACT The degradation of misfolded proteins is essential for cellular homeostasis. Misfolded proteins are normally degraded by the ubiquitin-proteasome system (UPS), and selective autophagy serves as a backup mechanism when the UPS is overloaded. Selective...
Journal Articles
In collection:
Proteostasis
J Cell Sci (2017) 130 (19): 3336–3346.
Published: 1 October 2017
... that the deubiquitylating enzyme Ubp12 interacts with Cdc48 and regulates proteasomal degradation of Rad23-dependent substrates in Saccharomyces cerevisiae. Overexpression of Ubp12 results in stabilization of Rad23-dependent substrates. We show that Ubp12 removes short ubiquitin chains from the N-terminal ubiquitin-like...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2014) 127 (15): 3294–3308.
Published: 1 August 2014
...-membrane-associated clusters, colocalizing with septins-2 and septin-7, which accumulated in these clusters only in the presence of LCA. The L428A/L429A mutation decreased co-clustering of LCA and septins and accelerated proteasomal and non-proteasomal degradation of LCA. Similarly, the impairment...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (14): 3149–3161.
Published: 15 July 2014
... dependencies of SIN proteins differ from those in mitotic cells, suggesting a modified functional organisation of the SIN during meiosis. Third, there is stage-specific degradation of SIN components in meiosis; Byr4p is degraded after meiosis I, whereas the degradation of Cdc7p, Cdc11p and Sid4p occurs after...
Includes: Supplementary data
Journal Articles
In collection:
Proteostasis
J Cell Sci (2014) 127 (13): 2898–2909.
Published: 1 July 2014
...Aishwarya Payapilly; Stephen High ABSTRACT BAG6 participates in protein quality control and, here, we address its role in endoplasmic-reticulum-associated degradation (ERAD) by using the polytopic membrane protein OpD, an opsin degron mutant. Both BAG6 knockdown and BAG6 overexpression delay OpD...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (10): 2189–2203.
Published: 15 May 2014
... in these pathways. We present evidence that the isoform 5 splice variant of PIPKIγ (PIPKIγi5) associates with E-cadherin and promotes its lysosomal degradation. Additionally, we show that the endosomal trafficking proteins SNX5 and SNX6 associate with PIPKIγi5 and inhibit PIPKIγi5-mediated E-cadherin degradation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (13): 2208–2219.
Published: 1 July 2011
...) and the phenylalanine/tyrosine-rich (FYRN) domain of MLL N . Free MLL N is destroyed by a mechanism that targets the FYRN domain, whereas free MLL C is exported to the cytoplasm and degraded by the proteasome. PHD1 is encoded by an alternatively spliced exon that is occasionally deleted in T-cell leukemia, and its...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (11): 1825–1831.
Published: 1 June 2008
... degradation after UV irradiation, the ubiquitin ligase responsible for securin ubiquitylation has not been well characterized. In this study, we show that UV radiation induced a marked reduction of securin in both the nucleus and cytoplasm. Moreover, we show that GSK-3β inhibitors prevent securin degradation...
Journal Articles
J Cell Sci (2006) 119 (22): 4702–4709.
Published: 15 November 2006
... the development of cancer. The key mechanism in regulation of the Wnt/β-catenin pathway is the amino-terminal phosphorylation of β-catenin, marking it for proteasomal degradation. Here we present small-molecule-based identification of protein kinase C (PKC)-mediated β-catenin phosphorylation as a novel mechanism...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (3): 571–581.
Published: 1 February 2006
... degradation of activated epidermal growth factor receptor was dramatically impaired in small inhibitory RNA-treated cells. We demonstrate that phosphatidylinositol 4-kinase IIα is necessary for the correct endocytic traffic and downregulation of activated epidermal growth factor receptor. * Author...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2005) 118 (5): 981–992.
Published: 1 March 2005
..., and as a component of dcp1 bodies in mammals, is also present in stress granules. Both stress granules and dcp1 bodies are involved in mRNA storage and/or degradation, although so far no link has been made between the two, in terms of neither morphology nor protein content. Here we show that transient CPEB1...
Journal Articles
J Cell Sci (2004) 117 (17): 3769–3783.
Published: 1 August 2004
... degradation of cyclin D3 in proteasomes, and that this occurs via glycogen synthase kinase-3β (GSK-3β)-mediated phosphorylation of cyclin D3 at Thr-283. Elevation of cAMP did not change the subcellular distribution of either cyclin D3 or GSK-3β. However, cAMP promoted the interaction between cyclin D3 and GSK...
Journal Articles
Journal Articles
J Cell Sci (2003) 116 (11): 2213–2222.
Published: 1 June 2003
...Marc A. Thomas; Nathalie Zosso; Isabelle Scerri; Nicolas Demaurex; Marc Chanson; Olivier Staub The gap junction protein connexin43 is known to have a rapid turnover,involving degradation by both the proteasomal and lysosomal systems, but the structural features of connexin43 that govern...
Journal Articles
Journal Articles
J Cell Sci (2003) 116 (9): 1707–1717.
Published: 1 May 2003
...Azadeh Arabi; Cecilia Rustum; Einar Hallberg; Anthony P. H. Wright c-Myc is a predominately nuclear transcription factor that is a substrate for rapid turnover by the proteasome system. Cancer-related mutations in c-Myc lead to defects in its degradation and thereby contribute to the increase...