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1-20 of 24
Keywords: Degradation
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Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2024) 137 (4): jcs261579.
Published: 28 February 2024
... CP110 CCP110 Degradation Proteasome Ubiquitylation National Institute of General Medical Sciences http://dx.doi.org/10.13039/100000057 R35GM144102 Dutch fabric merchant and exemplary microscopy pioneer Antonie van Leeuwenhoek described microorganisms with flagella, otherwise...
Journal Articles
In collection:
Proteostasis
Richard S. Marshall, David C. Gemperline, Fionn McLoughlin, Adam J. Book, Kay Hofmann, Richard D. Vierstra
Journal:
Journal of Cell Science
J Cell Sci (2020) 133 (21): jcs249862.
Published: 3 November 2020
... distinct chaperone that forms a tripartite complex with PBAC1 and PBAC2 to promote assembly of the 20S proteasome α-ring in Arabidopsis . Arabidopsis Chaperone Core protease Degradation Evolution Proteasome Proteolysis Proteostasis Regulatory particle Ubiquitin National...
Includes: Supplementary data
Journal Articles
In collection:
Autophagy
Journal:
Journal of Cell Science
J Cell Sci (2018) 131 (19): jcs214304.
Published: 4 October 2018
...Alberto Danieli; Sascha Martens ABSTRACT The degradation of misfolded proteins is essential for cellular homeostasis. Misfolded proteins are normally degraded by the ubiquitin-proteasome system (UPS), and selective autophagy serves as a backup mechanism when the UPS is overloaded. Selective...
Journal Articles
In collection:
Proteostasis
Journal:
Journal of Cell Science
J Cell Sci (2017) 130 (19): 3336–3346.
Published: 1 October 2017
... that the deubiquitylating enzyme Ubp12 interacts with Cdc48 and regulates proteasomal degradation of Rad23-dependent substrates in Saccharomyces cerevisiae. Overexpression of Ubp12 results in stabilization of Rad23-dependent substrates. We show that Ubp12 removes short ubiquitin chains from the N-terminal ubiquitin-like...
Includes: Supplementary data
Journal Articles
Max Z. Totland, Christian H. Bergsland, Tone A. Fykerud, Lars M. Knudsen, Nikoline L. Rasmussen, Peter W. Eide, Zeremariam Yohannes, Vigdis Sørensen, Andreas Brech, Ragnhild A. Lothe, Edward Leithe
Journal:
Journal of Cell Science
J Cell Sci (2017) 130 (17): 2867–2882.
Published: 1 September 2017
... to protein kinase C activation. Furthermore, overexpression of NEDD4, but not a catalytically inactive form of NEDD4, was found to result in nearly complete loss of gap junctions and increased lysosomal degradation of Cx43 in both HeLa and C33A cervical carcinoma cells. Collectively, the data provide new...
Includes: Supplementary data
Journal Articles
Chunbin Zou, Matthew J. Synan, Jin Li, Sheng Xiong, Michelle L. Manni, Yuan Liu, Bill B. Chen, Yutong Zhao, Sruti Shiva, Yulia Y. Tyurina, Jianfei Jiang, Janet S. Lee, Sudipta Das, Anuradha Ray, Prabir Ray, Valerian E. Kagan, Rama K. Mallampalli
Journal:
Journal of Cell Science
J Cell Sci (2016) 129 (1): 51–64.
Published: 1 January 2016
... mitochondrial function. Exposure to LPS selectively decreased levels of carbon 20 (C 20 )-containing cardiolipin molecular species, whereas the content of C 18 or C 16 species was not significantly altered, consistent with decreased levels of Alcat1. Alcat1 is a labile protein that is lysosomally degraded...
Includes: Supplementary data
Journal Articles
Olga Vagin, Elmira Tokhtaeva, Patton E. Garay, Puneet Souda, Sara Bassilian, Julian P. Whitelegge, Ramilla Lewis, George Sachs, Larry Wheeler, Roger Aoki, Ester Fernandez-Salas
Journal:
Journal of Cell Science
J Cell Sci (2014) 127 (15): 3294–3308.
Published: 1 August 2014
...-membrane-associated clusters, colocalizing with septins-2 and septin-7, which accumulated in these clusters only in the presence of LCA. The L428A/L429A mutation decreased co-clustering of LCA and septins and accelerated proteasomal and non-proteasomal degradation of LCA. Similarly, the impairment...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2014) 127 (14): 3149–3161.
Published: 15 July 2014
... dependencies of SIN proteins differ from those in mitotic cells, suggesting a modified functional organisation of the SIN during meiosis. Third, there is stage-specific degradation of SIN components in meiosis; Byr4p is degraded after meiosis I, whereas the degradation of Cdc7p, Cdc11p and Sid4p occurs after...
Includes: Supplementary data
Journal Articles
In collection:
Proteostasis
Journal:
Journal of Cell Science
J Cell Sci (2014) 127 (13): 2898–2909.
Published: 1 July 2014
...Aishwarya Payapilly; Stephen High ABSTRACT BAG6 participates in protein quality control and, here, we address its role in endoplasmic-reticulum-associated degradation (ERAD) by using the polytopic membrane protein OpD, an opsin degron mutant. Both BAG6 knockdown and BAG6 overexpression delay OpD...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2014) 127 (10): 2189–2203.
Published: 15 May 2014
... in these pathways. We present evidence that the isoform 5 splice variant of PIPKIγ (PIPKIγi5) associates with E-cadherin and promotes its lysosomal degradation. Additionally, we show that the endosomal trafficking proteins SNX5 and SNX6 associate with PIPKIγi5 and inhibit PIPKIγi5-mediated E-cadherin degradation...
Includes: Supplementary data
Journal Articles
Akihiko Yokoyama, Francesca Ficara, Mark J. Murphy, Christian Meisel, Alpana Naresh, Issay Kitabayashi, Michael L. Cleary
Journal:
Journal of Cell Science
J Cell Sci (2011) 124 (13): 2208–2219.
Published: 1 July 2011
...) and the phenylalanine/tyrosine-rich (FYRN) domain of MLL N . Free MLL N is destroyed by a mechanism that targets the FYRN domain, whereas free MLL C is exported to the cytoplasm and degraded by the proteasome. PHD1 is encoded by an alternatively spliced exon that is occasionally deleted in T-cell leukemia, and its...
Includes: Supplementary data
Journal Articles
M. Cristina Limón-Mortés, Mar Mora-Santos, Águeda Espina, José A. Pintor-Toro, Antonio López-Román, María Tortolero, Francisco Romero
Journal:
Journal of Cell Science
J Cell Sci (2008) 121 (11): 1825–1831.
Published: 1 June 2008
... degradation after UV irradiation, the ubiquitin ligase responsible for securin ubiquitylation has not been well characterized. In this study, we show that UV radiation induced a marked reduction of securin in both the nucleus and cytoplasm. Moreover, we show that GSK-3β inhibitors prevent securin degradation...
Journal Articles
Jungsug Gwak, Munju Cho, Soo-Jung Gong, Jaejoon Won, Dong-Eun Kim, Eun-Young Kim, Sang Sup Lee, Mina Kim, Tae Kook Kim, Jae-Gook Shin, Sangtaek Oh
Journal:
Journal of Cell Science
J Cell Sci (2006) 119 (22): 4702–4709.
Published: 15 November 2006
... the development of cancer. The key mechanism in regulation of the Wnt/β-catenin pathway is the amino-terminal phosphorylation of β-catenin, marking it for proteasomal degradation. Here we present small-molecule-based identification of protein kinase C (PKC)-mediated β-catenin phosphorylation as a novel mechanism...
Includes: Supplementary data
Journal Articles
Shane Minogue, Mark G. Waugh, Maria Antonietta De Matteis, David J. Stephens, Fedor Berditchevski, J. Justin Hsuan
Journal:
Journal of Cell Science
J Cell Sci (2006) 119 (3): 571–581.
Published: 1 February 2006
... degradation of activated epidermal growth factor receptor was dramatically impaired in small inhibitory RNA-treated cells. We demonstrate that phosphatidylinositol 4-kinase IIα is necessary for the correct endocytic traffic and downregulation of activated epidermal growth factor receptor. * Author...
Includes: Multimedia, Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2005) 118 (5): 981–992.
Published: 1 March 2005
..., and as a component of dcp1 bodies in mammals, is also present in stress granules. Both stress granules and dcp1 bodies are involved in mRNA storage and/or degradation, although so far no link has been made between the two, in terms of neither morphology nor protein content. Here we show that transient CPEB1...
Journal Articles
Soheil Naderi, Kristine B. Gutzkow, Hege U. Låhne, Siri Lefdal, W. Johnathan Ryves, Adrian J. Harwood, Heidi K. Blomhoff
Journal:
Journal of Cell Science
J Cell Sci (2004) 117 (17): 3769–3783.
Published: 1 August 2004
... degradation of cyclin D3 in proteasomes, and that this occurs via glycogen synthase kinase-3β (GSK-3β)-mediated phosphorylation of cyclin D3 at Thr-283. Elevation of cAMP did not change the subcellular distribution of either cyclin D3 or GSK-3β. However, cAMP promoted the interaction between cyclin D3 and GSK...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2003) 116 (24): 4957–4963.
Published: 15 December 2003
... thresholds of ERK activity control the expression of FRA-1. A basal activity is required to induce transcription of the FRA-1 gene, but additional higher levels of activity stabilize FRA-1 against proteasome-dependent degradation. These results provide a clear-cut example that the magnitude of ERK signalling...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2003) 116 (11): 2213–2222.
Published: 1 June 2003
...Marc A. Thomas; Nathalie Zosso; Isabelle Scerri; Nicolas Demaurex; Marc Chanson; Olivier Staub The gap junction protein connexin43 is known to have a rapid turnover,involving degradation by both the proteasomal and lysosomal systems, but the structural features of connexin43 that govern...
Journal Articles
Elizabeth A. Palmer, Kristina B. Kruse, Sheara W. Fewell, Sean M. Buchanan, Jeffrey L. Brodsky, Ardythe A. McCracken
Journal:
Journal of Cell Science
J Cell Sci (2003) 116 (11): 2361–2373.
Published: 1 June 2003
...Elizabeth A. Palmer; Kristina B. Kruse; Sheara W. Fewell; Sean M. Buchanan; Jeffrey L. Brodsky; Ardythe A. McCracken In the eukaryotic cell, a protein quality control process termed endoplasmic reticulum-associated degradation (ERAD) rids the ER of aberrant proteins and unassembled components...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2003) 116 (9): 1707–1717.
Published: 1 May 2003
...Azadeh Arabi; Cecilia Rustum; Einar Hallberg; Anthony P. H. Wright c-Myc is a predominately nuclear transcription factor that is a substrate for rapid turnover by the proteasome system. Cancer-related mutations in c-Myc lead to defects in its degradation and thereby contribute to the increase...
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