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Keywords: DYRK1A
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Journal Articles
J Cell Sci (2012) 125 (3): 561–569.
Published: 1 February 2012
... is structurally similar to β-catenin, regulates the expression of certain Wnt target genes, relieving repression conferred by the POZ- and zinc-finger-domain-containing transcription factor Kaiso. We have identified the kinase Dyrk1A as a component of the p120-catenin–Kaiso trajectory of the Wnt pathway. Using...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (1): 67–80.
Published: 1 January 2012
... and tyrosine phosphorylation. Here, we report on a novel regulatory mechanism; we demonstrate that N-WASP interacts with dual-specificity tyrosine-phosphorylation-regulated kinase 1A (Dyrk1A). In vitro kinase assays indicate that Dyrk1A directly phosphorylates the GTPase-binding domain (GBD) of N-WASP at three...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (14): 2424–2435.
Published: 15 July 2009
... with our panel of phosphospecific antibodies. These experiments identified dual-specificity tyrosine-phosphorylation-regulated kinase (DYRK1A) as the kinase that primes sites of GSK3β phosphorylation in MAP1B, and we confirmed this by knocking down DYRK1A in cultured embryonic cortical neurons by using...
Journal Articles
J Cell Sci (2009) 122 (10): 1574–1583.
Published: 15 May 2009
... effects produced on both development and health by small variations in the strength of the Notch signal. The Down-syndrome-associated kinase DYRK1A is coexpressed with Notch in various tissues during embryonic development. Here we show that DYRK1A moves to the nuclear transcription compartment where...
Includes: Supplementary data
Journal Articles
J Cell Sci (2003) 116 (15): 3099–3107.
Published: 1 August 2003
...Mónica Álvarez; Xavier Estivill; Susana de la Luna The protein kinase DYRK1A is distributed throughout the nucleoplasm,accumulating in speckle-like regions. We have found that this punctuated nuclear distribution is determined by the contribution of several elements. Although the nuclear import...