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Keywords: DSBs
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Journal Articles
Deoxyguanosine enhances the cytotoxicity of the topoisomerase i inhibitor camptothecin by reducing the repair of double-strand breaks induced in replicating dna
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Journal:
Journal of Cell Science
J Cell Sci (1991) 100 (4): 883–893.
Published: 1 December 1991
..., that the double-strand breaks (DSBs) are generated predominantly at sites of replication and not in the bulk DNA. A number of these DSBs are long-lived. The present study shows that dG affects the repair of these DSBs in a dose-dependent manner, and that a higher proportion of the initial lesions induced...
