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Keywords: DNA-binding domain
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Journal Articles
J Cell Sci (2001) 114 (20): 3771–3778.
Published: 15 October 2001
... implicated in two distinct modes of cell death induced by DNA damage, namely apoptosis and necrosis. During the execution phase of apoptosis, PARP-1 is specifically proteolyzed by caspases to produce an N-terminal DNA-binding domain (DBD) and a C-terminal catalytic fragment. The functional consequence...