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Keywords: DNA replication
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Journal Articles
J Cell Sci (2020) 133 (20): jcs244129.
Published: 30 October 2020
... replication stress. TDP-43 nucleic-acid-binding and self-assembly activities are important in inhibiting R-loop accumulation and preserving normal DNA replication. We also found that TDP-43 cytoplasmic aggregation impairs TDP-43 function in R-loop regulation. Furthermore, increased R-loop accumulation and DNA...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (19): 3297–3307.
Published: 01 October 2017
...Yi-Wen Xu; Lan-Rui Cao; Min Wang; Ying Xu; Xin Wu; Junping Liu; Chao Tong; Heng-Yu Fan ABSTRACT Precise regulation of DNA replication and genome integrity is crucial for gametogenesis and early embryogenesis. Cullin ring-finger ubiquitin ligase 4 (CRL4) has multiple functions in the maintenance...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (7): 1239–1250.
Published: 01 April 2017
...Eyemen Kheir; Torsten Krude ABSTRACT Non-coding Y RNAs are essential for the initiation of chromosomal DNA replication in vertebrates, yet their association with chromatin during the cell cycle is not characterised. Here, we quantify human Y RNA levels in soluble and chromatin-associated...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (11): 2118–2129.
Published: 01 June 2015
.... We demonstrate that sbRNAs from a range of nematode species are able to reconstitute the initiation of chromosomal DNA replication in the presence of replication proteins in vitro , and that conserved nucleotide sequence motifs are essential for this function. By functionally inactivating sbRNAs...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (8): 1518–1527.
Published: 15 April 2015
...Nikki A. Copeland; Heather E. Sercombe; Rosemary H. C. Wilson; Dawn Coverley CIZ1 is a nuclear matrix protein that cooperates with cyclin A2 (encoded by CCNA2 ) and CDK2 to promote mammalian DNA replication. We show here that cyclin‐A–CDK2 also negatively regulates CIZ1 activity by phosphorylation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (6): 1297–1306.
Published: 15 March 2013
...Mona Yekezare; Belén Gómez-González; John F. X. Diffley Summary DNA replication in eukaryotic cells initiates from multiple replication origins that are distributed throughout the genome. Coordinating the usage of these origins is crucial to ensure complete and timely replication of the entire...
Journal Articles
J Cell Sci (2013) 126 (4): 914–926.
Published: 15 February 2013
... transcription and replication imaging protocol), that reveals simultaneously mtDNA and RNA, and that can also be coupled to immunofluorescence for in situ protein examination. mTRIP reveals mitochondrial structures engaged in initiation of DNA replication by identification of a specific sequence...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (1): 31–41.
Published: 01 January 2013
... immediately behind the DNA replication fork. The core enzymes of the replisome (leading and lagging polymerases, i.e. DNA polymerases coupled to PCNA) move to the left (lagging strand at the bottom). Histone deposition and chaperone factors (CAF and Asf1) interact with PCNA ( Corpet and Almouzni, 2009...
Journal Articles
J Cell Sci (2012) 125 (11): 2753–2764.
Published: 01 June 2012
... of recombination. Following the initiation of DNA replication, the induction of these foci by replication stress is suppressed by defects in origin recognition complex (ORC) function, which is accompanied by loss of viability and severe mitotic defects. This suggests that cells lacking Brc1 undergo an ORC...
Journal Articles
J Cell Sci (2012) 125 (10): 2436–2445.
Published: 15 May 2012
... synthesis. Fourteen hours after the second thymidine release, when both control and geminin-depleted cells were mainly in G2–M, thymidine was again added for 10 hours, allowing cells that had completed S phase to progress through mitosis and G1, but preventing further DNA replication or re-replication ( Fig...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (4): 965–972.
Published: 15 February 2012
... of replication in higher eukaryotes and a means to dissect Orc-dependent and Orc-independent events at origins. * Author for correspondence ( s.cotterill@sgul.ac.uk ) 5 9 2011 © 2012. 2012 Orc DNA replication Origin of replication Gal4 Drosophila S2 cells Histone acetylation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (1): 133–143.
Published: 01 January 2012
...Madhav Jagannathan; Amos M. Sakwe; Tin Nguyen; Lori Frappier Mini-chromosome maintenance complex-binding protein (MCM-BP) was discovered as a protein that is strongly associated with human MCM proteins, known to be crucial for DNA replication in providing DNA helicase activity. The Xenopus MCM-BP...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (1): 209–219.
Published: 01 January 2012
...Rentian Wu; Jiafeng Wang; Chun Liang Regulation of DNA replication initiation is essential for the faithful inheritance of genetic information. Replication initiation is a multi-step process involving many factors including ORC, Cdt1p, Mcm2-7p and other proteins that bind to replication origins...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (12): 2058–2069.
Published: 15 June 2011
...Alice Tianbu Zhang; Alexander R. Langley; Christo P. Christov; Eyemen Kheir; Thomas Shafee; Timothy J. Gardiner; Torsten Krude Non-coding Y RNAs are required for the initiation of chromosomal DNA replication in mammalian cells. It is unknown how they perform this function or if they associate...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (22): 3933–3943.
Published: 15 November 2010
... in mitotic exit, providing new insight into the intricate regulation of DNA replication through the interplay of CDKs and the Cdc14p phosphatase. * Author for correspondence ( bccliang@ust.hk ) 7 7 2010 © 2010. 2010 Cdc14p phosphatase DNA replication Replication licensing...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (18): 3047–3051.
Published: 15 September 2010
.... , Fremont D. H. , Choi K. ( 2001 ). Oncogenic potential of the DNA replication licensing protein CDT1 . Oncogene 21 , 1150 - 1158 . Arias E. E. , Walter J. C. ( 2007 ). Strength in numbers: preventing rereplication via multiple mechanisms in eukaryotic cells . Genes Dev...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (17): 2867–2876.
Published: 01 September 2010
... to a clear change in nucleolar localization of hCdc14B, localization of hCdc14A was not affected by DNA damage, but its potential role in the DNA damage checkpoint has not been addressed ( Bassermann et al., 2008 ). A role for budding yeast ScCdc14 in DNA replication was originally demonstrated...
Journal Articles
J Cell Sci (2009) 122 (24): 4419–4426.
Published: 15 December 2009
... in the initiation of DNA replication. Here, we present evidence that 14-3-3 proteins are novel regulators of the initiation and elongation steps of DNA replication in Saccharomyces cerevisiae . The results show that the Bmh2 protein, one of the two 14-3-3 homologues in S. cerevisiae , interacts with Mcm2 and Orc2...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (22): 4070–4080.
Published: 15 November 2009
...Vitaly M. Vassin; Rachel William Anantha; Elena Sokolova; Shlomo Kanner; James A. Borowiec ATR is an essential kinase activated in response to DNA-replication stress, with a known target being the RPA2 subunit of human replication protein A (RPA). We find that S33-RPA2 phosphorylation by ATR occurs...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (16): 2836–2845.
Published: 15 August 2009
...Torsten Krude; Christo P. Christov; Olivier Hyrien; Kathrin Marheineke Non-coding Y RNAs have recently been identified as essential novel factors for chromosomal DNA replication in mammalian cell nuclei, but mechanistic details of their function have not been defined. Here, we identify...
Includes: Supplementary data