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Keywords: DNA repair
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Journal Articles
J Cell Sci (2020) 133 (12): jcs240036.
Published: 22 June 2020
... recombination repair (HRR) is suppressed by radiation exposure in a dose-dependent manner. RIF1 has a role in this dose-dependent suppression of HRR by controlling replication initiation. DNA repair Homologous recombination Radiation biology RIF1 The exposure of cells to ionizing radiation (IR...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (11): jcs240010.
Published: 08 June 2020
...Isabella Guardamagna; Elisabetta Bassi; Monica Savio; Paola Perucca; Ornella Cazzalini; Ennio Prosperi; Lucia A. Stivala ABSTRACT Assessment of DNA repair is an important endpoint measurement when studying the biochemical mechanisms of the DNA damage response and when investigating the efficacy of...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (10): jcs238709.
Published: 22 May 2020
... appears that in some situations the lack of all four of the polymerases is less deleterious than the absence of one. DNA repair Meiosis Translesion synthesis S. pombe Rec8 DDK Highlighted Article: Translesion synthesis polymerases are required for meiotic survival in fission yeast...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (3): jcs233437.
Published: 12 February 2020
...Rachel O'Dea; Corrado Santocanale ABSTRACT In order to prevent the deleterious effects of genotoxic agents, cells have developed complex surveillance mechanisms and DNA repair pathways that allow them to maintain genome integrity. The ubiquitin-specific protease 9X (USP9X) contributes to genome...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (13): jcs214932.
Published: 09 July 2018
...), culminating in the accumulation of DSBs. These effects were associated with a reduced expression of DNA damage signaling and repair proteins. Our data disclose a key role for dephosphorylation of PP1:NIPP1 substrates in setting the threshold for DNA repair, and indicate that activators of this phosphatase...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (13): jcs214924.
Published: 06 July 2018
... addition, cohesin plays important roles in processes such as DNA repair and regulation of gene expression. Mounting evidence suggests that various post-translational modifications, including phosphorylation, acetylation and sumoylation regulate cohesin functions. Our mass spectrometry analysis of cohesin...
Includes: Supplementary data
Journal Articles
In collection:
Mitochondria
J Cell Sci (2018) 131 (12): jcs213538.
Published: 25 June 2018
... maintenance in human cells exposed to oxidative stress. Mitochondria DNA repair 8-oxoG OGG1 The mammalian mitochondrial genome consists of a circular double-stranded DNA molecule that is ∼16 kb in length and accounts for 1%–2% of the total DNA in the cell. It encodes for only 13 proteins, all...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (24): 4449–4454.
Published: 15 December 2016
.... Food is a common source of mutagens, but little is known about how nutritional factors cause lasting genetic changes in the consuming organism. Here, we describe an unusual genetic interaction between DNA repair in the unicellular amoeba Dictyostelium discoideum and its natural bacterial food source...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (9): 1769–1774.
Published: 01 May 2016
... 2016 Summary: Knockout of the CEP164 ciliopathy gene ablates ciliogenesis but causes no increase in sensitivity to DNA damage induced by ionising or ultraviolet irradiation. Primary cilium Centrosome amplification DNA damage response DNA repair CEP164 Ciliopathy Primary...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (10): 1887–1900.
Published: 15 May 2015
... analysis. We identified 29 proteins that affected APB formation, which included proteins involved in telomere and chromatin organization, protein sumoylation and DNA repair. By integrating and extending these findings, we found that APB formation induced clustering of telomere repeats, telomere compaction...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (6): 1097–1107.
Published: 15 March 2015
... RRP6 of Drosophila melanogaster and its human ortholog EXOSC10 play a role in DNA repair. Here, we show that RRP6 and EXOSC10 are recruited to DNA double-strand breaks (DSBs) in S2 cells and HeLa cells, respectively. Depletion of RRP6/EXOSC10 does not interfere with the phosphorylation of the histone...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (9): 1869–1874.
Published: 01 May 2014
... role in DNA repair of double-strand breaks; SMCHD1 is recruited to sites of laser micro-irradiated damage along with other DNA repair factors, including Ku80 (also known as XRCC5 in mammals) and RAD51. Cells deficient in SMCHD1 show evidence of decreased efficiency of repair and cell viability after...
Journal Articles
J Cell Sci (2012) 125 (24): 6049–6057.
Published: 15 December 2012
...Fan Zhang; Gregory Bick; Jung-Young Park; Paul R. Andreassen Summary The PALB2 protein is associated with breast cancer susceptibility and Fanconi anemia. Notably, PALB2 is also required for DNA repair by homologous recombination (HR). However, the mechanisms that regulate PALB2, and the functional...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (9): 2127–2133.
Published: 01 May 2012
... KAP-1 dependent pathway . Nat. Cell Biol.   8 , 870 - 876 . ‡ These authors contributed equally to this work * Authors for correspondence ( p.krawczyk@amc.uva.nl ; j.a.aten@amc.uva.nl ) 12 12 2011 © 2012. 2012 Chromosome rearrangement DNA repair Double-strand...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (21): 3603–3618.
Published: 01 November 2011
... APBs with high efficiency in a self-organizing and self-propagating manner. These included: (1) PML and Sp100 as the constituting components of PML nuclear bodies, (2) telomere repeat binding factors 1 and 2 (TRF1 and TRF2, respectively), (3) the DNA repair protein NBS1 and (4) the SUMO E3 ligase MMS21...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (11): 1943–1951.
Published: 01 June 2011
.... * Present address: NYU School of Medicine, Radiation Oncology, 566 First avenue, New York City, NY 10016, USA ‡ These authors contributed equally to this work § Author for correspondence ( muller@ipbs.fr ) 14 2 2011 © 2011. 2011 DNA repair DNA-PK Hypoxia Stress response...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (1): 68–81.
Published: 01 January 2011
... differentiate transient foci from persistent foci, which we term ‘DNA segments with chromatin alterations reinforcing senescence’ (DNA-SCARS). Unlike transient foci, DNA-SCARS associate with PML nuclear bodies, lack the DNA repair proteins RPA and RAD51, lack single-stranded DNA and DNA synthesis and accumulate...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (17): 2867–2876.
Published: 01 September 2010
... assumed. * Author for correspondence ( e.schiebel@zmbh.uni-heidelberg.de ) © 2010. 2010 Dual-specificity phosphatase Cdc14 DNA damage Mitotic exit DNA replication DNA repair It is well recognized that reversible phosphorylation of proteins has a pivotal role in their respective...
Journal Articles
J Cell Sci (2010) 123 (7): 1124–1130.
Published: 01 April 2010
...-containing protein complexes. Furthermore, MRG15 interacts with the entire BRCA complex, which contains BRCA1, PALB2, BRCA2 and RAD51. Interestingly, MRG15-deficient cells, similarly to cells deficient in PALB2 or BRCA2, showed reduced efficiency for homology-directed DNA repair and hypersensitivity to DNA...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (20): 3638–3643.
Published: 15 October 2009
... Checkpoint DNA repair SMC5/6 Eukaryotic cells need to precisely duplicate their genomes during S phase in every cell cycle. However, exogenous and endogenous sources of DNA damage can block the progression of DNA replication forks, potentially resulting in a range of replication-associated DNA...
Includes: Supplementary data