...). Replication of a single nucleoid requires at least three DNA polymerase I-like proteins (i.e. POLIB, POLIC and POLID), each showing discrete localizations near the kDNA during S phase. POLIB and POLID have roles in minicircle replication but the specific role of POLIC in kDNA maintenance is less clear. Here...

... containing Cdt2). However, the factors involved in positive regulation of PrSet7 histone methylation remain undefined. Here, we present biochemical and genetic evidence for a previously undocumented interaction between Drosophila PrSet7 (dPrSet7) and DNA polymerase α in Drosophila . Depletion...

...Tomoo Ogi; Patricia Kannouche; Alan R. Lehmann DNA polymerases of the Y-family are involved in translesion DNA synthesis past different types of DNA damage. Previous work has shown that DNA polymerases η and ι are localised in replication factories during S phase, where they colocalise one-to-one...

... and the progression of the Hsp90 catalytic pathway. In this report we have identified the Drosophila Dpit47 protein (D NA p olymerase i nteracting t pr containing protein of 47 kDa) through its interaction with the DNA polymerase α. This protein is a predominantly nuclear protein, which forms a tight...

..., with emphasis on current uncertainties. Most DNA replication and repair enzymes in mammalian cell nuclei, e.g. DNA polymerases α, β, δ, and ε, have direct counterparts in yeast. In contrast, the abundant enzymes in mammalian cell nuclei that bind and are activated specifically by DNA strand interruptions, poly...

... was very stable. Foci remained when ∼90% chromatin was removed, suggesting they were attached to an underlying structure. * Author for correspondence 22 01 1993 24 02 1993 © 1993 by Company of Biologists 1993 replication foci DNA polymerase nucleoskeleton dTTP analogues...