... to substantial DNA methylation changes in the kidney endothelium and SOCS3iEKO promotes a divergent response in DNA methylation in following exposure to LPS. Furthermore, we found that increased STAT and AP1 (JunB, BATF and Fos) transcriptional activity was associated with DNA methylation changes, suggesting...

... DNA methylation and histone modifications were significantly altered in the stem-like and non-stem phenotypes. In particular, in the stem-like phenotype, the miR-200b-200a-429 cluster was silenced primarily through polycomb group-mediated histone modifications whereas the miR-200c-141 cluster...

...Joe Burrage; Ausma Termanis; Andreas Geissner; Kevin Myant; Katrina Gordon; Irina Stancheva Summary LSH, a protein related to the SNF2 family of chromatin-remodelling ATPases, is essential for the correct establishment of DNA methylation levels and patterns in plants and mammalian cells. However...

... such as migration, extracellular matrix production and assembly in 3D self-assembled tissues. To determine potential regulatory regions predictive of expression of PDGFRβ following differentiation from ESCs and iPSCs, we analyzed the DNA methylation status of a region of the PDGFRB promoter that contains multiple...

...., Carrington, J. C. and Jacobsen, S. E. ( 2004 ). RNA silencing genes control de novo DNA methylation. Science 303 , 1336 . Chan, S. W., Henderson, I. R., Zhang, X., Shah, G., Chien, J. S. and Jacobsen, S. E. ( 2006a ). RNAi, DRD1, and histone methylation actively target developmentally important non...

... hybridization, Aurora-B and H3S10 phosphorylated foci were found more frequently at larger pericentromeres than at smaller ones, revealing a preferential phosphorylation of pericentromeres, exhibiting a high density of methyl cytosines. Disruption of DNA methylation inhibited pericentromeric Aurora-B targeting...

... Limited 2006 2006 DNA methylation Transcriptional repression Epigenetics Methyl CpG binding protein Eukaryotic chromosomes are the repositories of the genetic information necessary to direct the synthesis of cellular components. Information is embedded in them at multiple levels...

... and induced changes in DNA methylation and histone acetylation, using in situ hybridisation and confocal 3D imaging. After germinating seeds either in the presence of 5-Azacytidine (5-AC), which leads to DNA hypomethylation, or trichostatin A (TSA), which results in histone hyperacetylation, the architecture...

...Adrian Bird; Peri Tate; Xinsheng Nan; Javier Campoy; Richard Meehan; Sally Cross; Susan Tweedie; Jillian Charlton; Donald Macleod ABSTRACT We have been studying the evolution and function of DNA methylation in vertebrate animals using three related approaches. The first is to further characterise...

.... © The Company of Biologists Limited 1992 1992 DNA methylation transcriptional repression methyl-CpG binding proteins In mammals approximately 70% of all CpGs are methylated at the 5 position of cytosine. It is not clear what the functional role of this modification is, but it has...

...Stephen G. Grant; Ronald G. Worton ABSTRACT Treatment with 5-azacytidine, a potent inhibitor of DNA methylation, was used to induce activation of the selectable hprt gene on the inactive X chromosome in a diploid female Chinese hamster cell line. The transformed, stably diploid cell line F3B...