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Keywords: DNA double-strand breaks
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Journal Articles
J Cell Sci (2022) 135 (11): jcs259514.
Published: 8 June 2022
... demonstrate that dual-specificity tyrosine-regulated kinase 2 (DYRK2) is a novel regulator of neddylation and maintains genome stability. Deletion of DYRK2 leads to persistent DNA double-strand breaks (DSBs) and subsequent genome instability. Mechanistically, DYRK2 promotes neddylation through forming...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (13): jcs214932.
Published: 9 July 2018
... in a manner that requires both PP1 activity and substrate recruitment via the ForkHead Associated domain of NIPP1. More specifically, PP1–NIPP1 expression resulted in the build up of RNA–DNA hybrids (R-loops), enhanced chromatin compaction and a diminished repair of DNA double-strand breaks (DSBs...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (15): 3529–3534.
Published: 1 August 2012
... by conventional microscopy. Consistent with a role for 53BP1 in promoting DNA double-strand break repair by non-homologous end joining, 53BP1 enrichment in IRIF is most prominent in the G0/G1 cell cycle phases, where it is enriched in dense globular structures. By contrast, as cells transition through S phase...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2012) 125 (1): 189–199.
Published: 1 January 2012
... therefore tested whether the sensing and repair of DNA double-strand breaks (DNA-dsbs) is altered in irradiated cells kept under continual oxic, hypoxic or anoxic conditions. Synchronized G0–G1 human fibroblasts were irradiated (0–10 Gy) after initial gassing with 0% O 2 (anoxia), 0.2% O 2 (hypoxia) or 21...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (22): 4644–4649.
Published: 15 November 2006
... in reduction of DNA double-strand breaks and damage checkpoint signaling, although the treatment significantly reversed the aberrant shape of their nuclei. This suggests that DNA damage accumulation and aberrant nuclear morphology are independent phenotypes arising from prelamin A accumulation...
Journal Articles
J Cell Sci (2001) 114 (18): 3345–3357.
Published: 15 September 2001
... of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance Nucleic Acids Res . 24 , 4639 -4648. Brush, G. S., Anderson, C. W. and Kelly, T. J. ( 1994 ). The DNA-activated protein kinase is required for the phosphorylation of replication protein...