...Simon Janes; Ulrike Schmidt; Karim Ashour Garrido; Nadja Ney; Susanna Concilio; Mohamed Zekri; Thomas Caspari Summary Exposure of human cells to heat switches the activating signal of the DNA damage checkpoint from genotoxic to temperature stress. This change reduces mitotic commitment...

...) * These authors contributed equally to this work 18 1 2007 © The Company of Biologists Limited 2007 2007 Drosophila DNA damage checkpoint Meiotic checkpoint Hus1 In many cell types specific checkpoint mechanisms exist that monitor the integrity of the chromosomes...

... here that depletion of Top3 activates the DNA damage checkpoint associated with phosphorylation of the checkpoint kinase Chk1. Despite activation of this checkpoint, top3 cells exit the arrest but fail to undergo faithful chromosome segregation. However, these mitotic defects are secondary...

.... If G1/S DNA damage checkpoints allowed for completion of DNA repair, then it might be expected that cells would not delay in a subsequent mitosis. Unirradiated cells reach a 2N DNA content at 120 minutes after release fromαf (Fig. 2A). A return to 1N DNA content is observed at 150 minutes...

... such roles. Perhaps more surprisingly, the two kinases not only have different targets in different organisms but also seem to respond to different signals in different organisms. So, whereas in fission yeast Chk1 is required for the DNA damage checkpoint and Cds1 is specifically involved in the replication...