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Keywords: DNA damage
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Journal Articles
J Cell Sci (2021) 134 (12): jcs255786.
Published: 17 June 2021
.... Photobiol. B Biol. 209 , 111951 . 10.1016/j.jphotobiol.2020.111951 Binz , S. K. , Sheehan , A. M. and Wold , M. S. ( 2004 ). Replication protein A phosphorylation and the cellular response to DNA damage . DNA Repair 3 , 1015 - 1024 . 10.1016/j.dnarep.2004.03.028 Block...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (6): jcs249706.
Published: 22 March 2021
...Matteo Cabrini; Marco Roncador; Alessandro Galbiati; Lina Cipolla; Antonio Maffia; Fabio Iannelli; Simone Sabbioneda; Fabrizio d’Adda di Fagagna; Sofia Francia ABSTRACT The DNA damage response (DDR) is the signaling cascade that recognizes DNA double-strand breaks (DSBs) and promotes...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (2): jcs243394.
Published: 27 January 2021
..., promoting the epithelial–mesenchymal transition (EMT); however, the underlying mechanisms are unknown. We found that silica, matrix stiffening or their combination triggered Ac-α-Tub downregulation in alveolar epithelial cells, followed by DNA damage and replication stress. α-TAT1 elevated Ac-α-Tub to limit...
Includes: Supplementary data
Journal Articles
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Cilia and Flagella
J Cell Sci (2021) 134 (2): jcs255950.
Published: 27 January 2021
.... , Vagnarelli , P. , Earnshaw , W. , Gillespie , D. , Jallepalli , P. and Schiebel , E. ( 2010 ). Vertebrate cells genetically deficient for Cdc14A or Cdc14B retain DNA damage checkpoint proficiency but are impaired in DNA repair . J. Cell Biol. 189 , 631 - 639 . 10.1083/jcb...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (13): jcs244442.
Published: 01 July 2020
...Cedric Landmann; Priscillia Pierre-Elies; Damien Goutte-Gattat; Emilie Montembault; Marie-Charlotte Claverie; Anne Royou ABSTRACT The DNA damage sensor Mre11-Rad50-Nbs1 complex and Polo kinase are recruited to DNA lesions during mitosis. However, their mechanism of recruitment is elusive. Here...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (11): jcs242420.
Published: 04 June 2020
... in structure of nuclear myosins, their nuclear import and their roles within transcription, DNA damage, chromatin organisation and viral infections. We will also consider both the biochemical and biophysical properties and restraints that are placed on these multifunctional motors, and how they link...
Journal Articles
J Cell Sci (2020) 133 (9): jcs235473.
Published: 11 May 2020
...Imke K. Mandemaker; Di Zhou; Serena T. Bruens; Dick H. Dekkers; Pernette J. Verschure; Raghu R. Edupuganti; Eran Meshorer; Jeroen A. A. Demmers; Jurgen A. Marteijn ABSTRACT Many chromatin remodeling and modifying proteins are involved in the DNA damage response, where they stimulate repair...
Includes: Supplementary data
Journal Articles
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Stem Cells
J Cell Sci (2020) 133 (8): jcs237545.
Published: 24 April 2020
... that despite a similar DNA-damaging effect along the anteroposterior axis of intact animals, responses differed between anterior and posterior fragments after amputation. Stem cell proliferation and differentiation proceeded successfully in the amputated heads, leading to regeneration of missing tissues. Stem...
Includes: Supplementary data
Journal Articles
In collection:
Polarity
J Cell Sci (2019) 132 (8): jcs225243.
Published: 15 April 2019
... depletion alters neither the apical localization of TnI or Bazooka, nor the basal localization of Dlg. Nevertheless, overexpressing PI3K prevents the defects seen upon TnI depletion. TnI loss-of-function disrupts cytoskeletal β-Catenin, E-Cadherin and γ-Tubulin, and causes an increase in DNA damage...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (23): jcs219311.
Published: 05 December 2018
...Xiangduo Kong; Gladys Mae Saquilabon Cruz; Sally Loyal Trinh; Xu-Dong Zhu; Michael W. Berns; Kyoko Yokomori ABSTRACT TRF2 (TERF2) binds to telomeric repeats and is critical for telomere integrity. Evidence suggests that it also localizes to non-telomeric DNA damage sites. However, this recruitment...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (13): jcs214932.
Published: 09 July 2018
...), culminating in the accumulation of DSBs. These effects were associated with a reduced expression of DNA damage signaling and repair proteins. Our data disclose a key role for dephosphorylation of PP1:NIPP1 substrates in setting the threshold for DNA repair, and indicate that activators of this phosphatase...
Includes: Supplementary data
Journal Articles
In collection:
Stem Cells
J Cell Sci (2018) 131 (2): jcs204065.
Published: 29 January 2018
... divisions and that DNA damage promotes BR-dependent paracrine signaling in the stem cell niche as a prerequisite to stem cell replenishment. § These authors contributed equally to this work * Present address: Carnegie Institution for Science, Department of Plant Biology, 260 Panama St...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (21): 3749–3763.
Published: 01 November 2017
...: Alkylation damage induced cellular transformation in breast acinar cultures, which was partially rescued by DNA-PK inhibition. DNA damage MNU Polarity EMT Golgi dispersal pDNA-PKcs Many harmful chemicals in the environment challenge human DNA. Aberrant regulation of the DNA damage response...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (19): 3347–3359.
Published: 01 October 2017
... joining (NHEJ), which relies on 53BP1. The balance between NHEJ and HR depends, in part, on whether 53BP1 predominates in binding to damage sites, where it protects the DNA ends from resection. The nucleoporin Nup153 has been implicated in the DNA damage response, attributed to a role in promoting nuclear...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (10): 1717–1729.
Published: 15 May 2017
... that α-catenin is able to modulate the sensitivity of cells to DNA damage and toxicity. Furthermore, nuclear α-catenin is actively recruited to sites of DNA damage. This recruitment occurs in a β-catenin-dependent manner and requires nuclear actin polymerization. These findings provide mechanistic...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (6): 1134–1146.
Published: 15 March 2017
... tolerance to DNA damage. Here, we show that NIPBL is recruited to DNA damage throughout the cell cycle via independent mechanisms, influenced by type of damage. First, the heterochromatin protein HP1γ (also known as CBX3) recruits NIPBL to DNA double-strand breaks (DSBs) through the corresponding HP1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (4): 788–803.
Published: 15 February 2016
... differentiation by employing the GSK-J4 inhibitor, which is specific for KDM6 proteins, and by targeted gene knockout (KO) and knockdown. We observe that inhibition of the H3K27 demethylase activity induces DNA damage along with activation of the DNA damage response (DDR) and cell death in differentiating...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (23): 4255–4262.
Published: 01 December 2015
... and the accompanying poster, we present an overview of recent advances in ATR and ATM research with emphasis on that into the modes of ATM and ATR activation, the different signaling pathways they participate in – including those that do not involve DNA damage – and highlight their relevance in cancer. * Authors...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (3): 599–604.
Published: 01 February 2015
... of Biologists Ltd 2015 Chromatin mobility Paired-particle tracking DNA damage In eukaryotes, DNA is wrapped around histone proteins in a complex structure, the chromatin. Higher-order organization of the chromatin exerts an important influence on genomic functions, including gene expression, DNA...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (18): 3885–3891.
Published: 15 September 2014
...Robert Y. L. Tsai ABSTRACT A quintessential trait of stem cells is embedded in their ability to self-renew without incurring DNA damage as a result of genome replication. One key self-renewal factor is the nucleolar GTP-binding protein nucleostemin (also known as guanine-nucleotide-binding protein...