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Keywords: DNA damage
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Journal Articles
J Cell Sci (2022) 135 (14): jcs259009.
Published: 19 July 2022
... constrained by concerns of unequal nuclear expansion. Here, we demonstrate the conditions for isotropic expansion of the nucleus at a resolution equal to or better than 120–130 nm (pre-expansion). Using the DNA damage response proteins BRCA1, 53BP1 (also known as TP53BP1) and RAD51 as exemplars, we...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (8): jcs259114.
Published: 28 April 2022
...Gérald Lossaint; Anđela Horvat; Véronique Gire; Katarina Bačević; Karim Mrouj; Fabienne Charrier-Savournin; Virginie Georget; Daniel Fisher; Vjekoslav Dulić ABSTRACT Senescence is an irreversible withdrawal from cell proliferation that can be initiated after DNA damage-induced cell cycle arrest...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (12): jcs255786.
Published: 17 June 2021
.... , Sheehan , A. M. and Wold , M. S. ( 2004 ). Replication protein A phosphorylation and the cellular response to DNA damage . DNA Repair 3 , 1015 - 1024 . 10.1016/j.dnarep.2004.03.028 Block , W. D. , Yu , Y. and Lees–Miller , S. P. ( 2004 ). Phosphatidyl inositol 3...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (6): jcs249706.
Published: 22 March 2021
...Matteo Cabrini; Marco Roncador; Alessandro Galbiati; Lina Cipolla; Antonio Maffia; Fabio Iannelli; Simone Sabbioneda; Fabrizio d’Adda di Fagagna; Sofia Francia ABSTRACT The DNA damage response (DDR) is the signaling cascade that recognizes DNA double-strand breaks (DSBs) and promotes...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (2): jcs243394.
Published: 27 January 2021
..., promoting the epithelial–mesenchymal transition (EMT); however, the underlying mechanisms are unknown. We found that silica, matrix stiffening or their combination triggered Ac-α-Tub downregulation in alveolar epithelial cells, followed by DNA damage and replication stress. α-TAT1 elevated Ac-α-Tub to limit...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2021) 134 (2): jcs255950.
Published: 27 January 2021
... in processes such as ciliogenesis. Human CDC14 Mitosis Cytokinesis DNA damage Ciliogenesis CDC14 encodes an essential highly conserved dual specificity protein phosphatase that in budding yeast Saccharomyces cerevisiae promotes mitotic exit, the transition from mitosis into G1 phase...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (13): jcs244442.
Published: 1 July 2020
...Cedric Landmann; Priscillia Pierre-Elies; Damien Goutte-Gattat; Emilie Montembault; Marie-Charlotte Claverie; Anne Royou ABSTRACT The DNA damage sensor Mre11-Rad50-Nbs1 complex and Polo kinase are recruited to DNA lesions during mitosis. However, their mechanism of recruitment is elusive. Here...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (11): jcs242420.
Published: 4 June 2020
... in structure of nuclear myosins, their nuclear import and their roles within transcription, DNA damage, chromatin organisation and viral infections. We will also consider both the biochemical and biophysical properties and restraints that are placed on these multifunctional motors, and how they link...
Journal Articles
J Cell Sci (2020) 133 (9): jcs235473.
Published: 11 May 2020
...Imke K. Mandemaker; Di Zhou; Serena T. Bruens; Dick H. Dekkers; Pernette J. Verschure; Raghu R. Edupuganti; Eran Meshorer; Jeroen A. A. Demmers; Jurgen A. Marteijn ABSTRACT Many chromatin remodeling and modifying proteins are involved in the DNA damage response, where they stimulate repair...
Includes: Supplementary data
Journal Articles
In collection:
Stem Cells
J Cell Sci (2020) 133 (8): jcs237545.
Published: 24 April 2020
... that despite a similar DNA-damaging effect along the anteroposterior axis of intact animals, responses differed between anterior and posterior fragments after amputation. Stem cell proliferation and differentiation proceeded successfully in the amputated heads, leading to regeneration of missing tissues. Stem...
Includes: Supplementary data
Journal Articles
In collection:
Polarity
J Cell Sci (2019) 132 (8): jcs225243.
Published: 15 April 2019
... depletion alters neither the apical localization of TnI or Bazooka, nor the basal localization of Dlg. Nevertheless, overexpressing PI3K prevents the defects seen upon TnI depletion. TnI loss-of-function disrupts cytoskeletal β-Catenin, E-Cadherin and γ-Tubulin, and causes an increase in DNA damage...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (23): jcs219311.
Published: 5 December 2018
...Xiangduo Kong; Gladys Mae Saquilabon Cruz; Sally Loyal Trinh; Xu-Dong Zhu; Michael W. Berns; Kyoko Yokomori ABSTRACT TRF2 (TERF2) binds to telomeric repeats and is critical for telomere integrity. Evidence suggests that it also localizes to non-telomeric DNA damage sites. However, this recruitment...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (13): jcs214932.
Published: 9 July 2018
...), culminating in the accumulation of DSBs. These effects were associated with a reduced expression of DNA damage signaling and repair proteins. Our data disclose a key role for dephosphorylation of PP1:NIPP1 substrates in setting the threshold for DNA repair, and indicate that activators of this phosphatase...
Includes: Supplementary data
Journal Articles
In collection:
Stem Cells
J Cell Sci (2018) 131 (2): jcs204065.
Published: 29 January 2018
... divisions and that DNA damage promotes BR-dependent paracrine signaling in the stem cell niche as a prerequisite to stem cell replenishment. These questions prompted us to investigate BR-mediated regulation of quiescence and its impact on stem cell regeneration after DNA damage at the local level...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (21): 3749–3763.
Published: 1 November 2017
... was discarded (leaving behind about 100 µl of solution), mixed well and used for subsequent steps. Alkaline and Neutral Comet assays were performed according to standard protocols ( Olive and Banáth, 2006 ). To calculate the extent of DNA damage, the percentage tail length and relative DNA content were...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (19): 3347–3359.
Published: 1 October 2017
... joining (NHEJ), which relies on 53BP1. The balance between NHEJ and HR depends, in part, on whether 53BP1 predominates in binding to damage sites, where it protects the DNA ends from resection. The nucleoporin Nup153 has been implicated in the DNA damage response, attributed to a role in promoting nuclear...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (10): 1717–1729.
Published: 15 May 2017
... that α-catenin is able to modulate the sensitivity of cells to DNA damage and toxicity. Furthermore, nuclear α-catenin is actively recruited to sites of DNA damage. This recruitment occurs in a β-catenin-dependent manner and requires nuclear actin polymerization. These findings provide mechanistic...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (6): 1134–1146.
Published: 15 March 2017
... tolerance to DNA damage. Here, we show that NIPBL is recruited to DNA damage throughout the cell cycle via independent mechanisms, influenced by type of damage. First, the heterochromatin protein HP1γ (also known as CBX3) recruits NIPBL to DNA double-strand breaks (DSBs) through the corresponding HP1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (4): 788–803.
Published: 15 February 2016
... differentiation by employing the GSK-J4 inhibitor, which is specific for KDM6 proteins, and by targeted gene knockout (KO) and knockdown. We observe that inhibition of the H3K27 demethylase activity induces DNA damage along with activation of the DNA damage response (DDR) and cell death in differentiating...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (23): 4255–4262.
Published: 1 December 2015
... and the accompanying poster, we present an overview of recent advances in ATR and ATM research with emphasis on that into the modes of ATM and ATR activation, the different signaling pathways they participate in – including those that do not involve DNA damage – and highlight their relevance in cancer. * Authors...
Includes: Supplementary data