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Keywords: DNA damage
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Journal Articles
J Cell Sci (2024) 137 (6): jcs261630.
Published: 2 April 2024
.... DNA damage DNA repair Chromatin dynamics Nuclear actin Nuclear architecture Oocyte development Transcription Germany's Excellence Strategy 390939984 Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659 GR 2111/13-1 Schweizerischer...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2023) 136 (1): jcs260563.
Published: 12 January 2023
... of the nuclear alterations also contain autophagic proteins and type II DNA topoisomerases (TOP2A and TOP2B), or the nucleolar protein fibrillarin, implying they are also targets of nucleophagy. We propose that basal nucleophagy contributes to genome and nuclear stability, as well as in response to DNA damage...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (14): jcs259009.
Published: 19 July 2022
... constrained by concerns of unequal nuclear expansion. Here, we demonstrate the conditions for isotropic expansion of the nucleus at a resolution equal to or better than 120–130 nm (pre-expansion). Using the DNA damage response proteins BRCA1, 53BP1 (also known as TP53BP1) and RAD51 as exemplars, we...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (8): jcs259114.
Published: 28 April 2022
...Gérald Lossaint; Anđela Horvat; Véronique Gire; Katarina Bačević; Karim Mrouj; Fabienne Charrier-Savournin; Virginie Georget; Daniel Fisher; Vjekoslav Dulić ABSTRACT Senescence is an irreversible withdrawal from cell proliferation that can be initiated after DNA damage-induced cell cycle arrest...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (12): jcs255786.
Published: 17 June 2021
... the number of apoptotic cells. DNA damage responses rely on the efficiency of the DNA repair machinery to eliminate at least 50% of the DNA damage within the first 8-10 h post-UVBR irradiation ( Friedberg et al., 2005 ). Impairment of critical mediators facilitating DNA repair leads to the accumulation...
Includes: Supplementary data
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Cilia and flagella
J Cell Sci (2021) 134 (2): jcs255950.
Published: 27 January 2021
.... , Vagnarelli , P. , Earnshaw , W. , Gillespie , D. , Jallepalli , P. and Schiebel , E. ( 2010 ). Vertebrate cells genetically deficient for Cdc14A or Cdc14B retain DNA damage checkpoint proficiency but are impaired in DNA repair . J. Cell Biol. 189 , 631 - 639 . 10.1083/jcb...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (13): jcs244442.
Published: 1 July 2020
...Cedric Landmann; Priscillia Pierre-Elies; Damien Goutte-Gattat; Emilie Montembault; Marie-Charlotte Claverie; Anne Royou ABSTRACT The DNA damage sensor Mre11-Rad50-Nbs1 complex and Polo kinase are recruited to DNA lesions during mitosis. However, their mechanism of recruitment is elusive. Here...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (11): jcs242420.
Published: 4 June 2020
... in structure of nuclear myosins, their nuclear import and their roles within transcription, DNA damage, chromatin organisation and viral infections. We will also consider both the biochemical and biophysical properties and restraints that are placed on these multifunctional motors, and how they link...
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Polarity
J Cell Sci (2019) 132 (8): jcs225243.
Published: 15 April 2019
... depletion alters neither the apical localization of TnI or Bazooka, nor the basal localization of Dlg. Nevertheless, overexpressing PI3K prevents the defects seen upon TnI depletion. TnI loss-of-function disrupts cytoskeletal β-Catenin, E-Cadherin and γ-Tubulin, and causes an increase in DNA damage...
Includes: Supplementary data
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Journal Articles
J Cell Sci (2018) 131 (13): jcs214932.
Published: 9 July 2018
...), culminating in the accumulation of DSBs. These effects were associated with a reduced expression of DNA damage signaling and repair proteins. Our data disclose a key role for dephosphorylation of PP1:NIPP1 substrates in setting the threshold for DNA repair, and indicate that activators of this phosphatase...
Includes: Supplementary data
Journal Articles
In collection:
Stem cells
J Cell Sci (2018) 131 (2): jcs204065.
Published: 29 January 2018
... divisions and that DNA damage promotes BR-dependent paracrine signaling in the stem cell niche as a prerequisite to stem cell replenishment. Brassinosteroids (BRs) are plant steroid hormones that were originally discovered in Brassica napus pollen for their ability to promote growth when exogenously...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (21): 3749–3763.
Published: 1 November 2017
..., 2006 ). To calculate the extent of DNA damage, the percentage tail length and relative DNA content were calculated using the Comet assay plugin in ImageJ software. MCF10A cells seeded in an 8-well chamber cover glass at a density of 5×10 4 cells per well were incubated for 16 h. The cells...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (19): 3347–3359.
Published: 1 October 2017
... joining (NHEJ), which relies on 53BP1. The balance between NHEJ and HR depends, in part, on whether 53BP1 predominates in binding to damage sites, where it protects the DNA ends from resection. The nucleoporin Nup153 has been implicated in the DNA damage response, attributed to a role in promoting nuclear...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (10): 1717–1729.
Published: 15 May 2017
... that α-catenin is able to modulate the sensitivity of cells to DNA damage and toxicity. Furthermore, nuclear α-catenin is actively recruited to sites of DNA damage. This recruitment occurs in a β-catenin-dependent manner and requires nuclear actin polymerization. These findings provide mechanistic...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (6): 1134–1146.
Published: 15 March 2017
... tolerance to DNA damage. Here, we show that NIPBL is recruited to DNA damage throughout the cell cycle via independent mechanisms, influenced by type of damage. First, the heterochromatin protein HP1γ (also known as CBX3) recruits NIPBL to DNA double-strand breaks (DSBs) through the corresponding HP1...
Includes: Supplementary data