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Keywords: DDB1
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Journal Articles
J Cell Sci (2018) 131 (15): jcs218016.
Published: 01 August 2018
... of Smo trafficking remains poorly understood. Here, we identified the Cul4–DDB1 E3 ubiquitin ligase complex as being essential for Smo ubiquitylation and cell surface clearance. We found that the C-terminal intracellular domain of Smo recruits Cul4–DDB1 through the β subunit of trimeric G protein (Gβ...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (8): jcs213868.
Published: 26 April 2018
... ligase (designated as CRL7 SMU1 complex) that has an essential role in the maintenance of chromatid cohesion. We demonstrate that SMU1, DDB1, CUL7 and RNF40 are integral components of this complex. SMU1, by acting as a substrate recognition module, binds to H2B and mediates monoubiquitylation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (21): 4985–4994.
Published: 01 November 2013
...Oliver Fleck; Rasmus Vejrup-Hansen; Adam Watson; Antony M. Carr; Olaf Nielsen; Christian Holmberg Summary Cullin4, Ddb1 and Cdt2 are core subunits of the ubiquitin ligase complex CRL4 Cdt2 , which controls genome stability by targeting Spd1 for degradation during DNA replication and repair...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (14): 2393–2401.
Published: 15 July 2009
...Hsiu-Chen Lin; June-Tai Wu; Bertrand Chin-Ming Tan; Cheng-Ting Chien In higher eukaryotes, the pre-replication complex (pre-RC) component Cdt1 is the major regulator in licensing control for DNA replication. The Cul4-DDB1-based ubiquitin ligase mediates Cdt1 ubiquitylation for subsequent...
Includes: Supplementary data