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Keywords: Cytoskeleton
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Journal Articles
In collection:
Mechanobiology
J Cell Sci (2021) 134 (6): jcs240226.
Published: 22 March 2021
..., and the mechanobiological responses of pericytes to these forces. Pericyte Cytoskeleton Contractility Cell migration Cell mechanics In vitro models Pericytes are mural cells of the microvasculature that are embedded in the vessel basement membrane (BM), where they surround...
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2021) 134 (6): jcs247866.
Published: 11 March 2021
... attachments to contractile F-actin. Summary: Clarification of the relationship between two tension-regulated proteins, LIMD1 and TRIP6, and identification of a role for TRIP6 in regulating the organization of the actin cytoskeleton. Mechanotransduction Tension Hippo Junction LIMD1 Cytoskeleton...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2021) 134 (6): jcs256180.
Published: 11 March 2021
... axon initial segment Ranbp2 are shown to be based on NF186-cross-reacting antibodies and the intrinsic ability of an N-terminal fragment of Ranbp2 to bind to stable microtubules. Axon Cytoskeleton Antibody Ranbp2 Nup358 The axon initial segment (AIS) is essential for the proper...
Journal Articles
J Cell Sci (2021) 134 (5): jcs252403.
Published: 08 March 2021
... the reorganization of the cytoskeleton and positioning of intracellular organelles. We show this model is amenable to screening C. trachomatis mutants for defects in the fusion of pathogenic vacuoles, the recruitment of intracellular organelles and inhibition of cell death. Moreover, we reconstructed...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2021) 134 (5): jcs251298.
Published: 25 February 2021
... manner, and that this is necessary for their contraction and remodeling into rings. We demonstrate that the structural integrity of these incipient septin discs requires both an intact F-actin and microtubule cytoskeleton and provide fundamental new insight into their functional organization within the...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (4): jcs257006.
Published: 22 February 2021
... is critical for generating functional multi-ciliated epithelium in the mouse oviduct. Basal body Cytoskeleton Oviduct Planar cell polarity Reproduction Super-resolution microscopy Multi-ciliated cells (MCCs), which have a few hundred cilia on their apical surface ( Brooks and...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (3): jcs248393.
Published: 10 February 2021
.... Rho GTPase Signal transduction Trio family Cytoskeleton Neurodevelopmental disorders Cell morphogenesis Trio family proteins are key regulators of cell motility and morphogenesis, tissue development, and protein trafficking and secretion in numerous biological contexts, including their...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2021) 134 (3): jcs248385.
Published: 08 February 2021
...Gillian DeWane; Alicia M. Salvi; Kris A. DeMali ABSTRACT Attention has long focused on the actin cytoskeleton as a unit capable of organizing into ensembles that control cell shape, polarity, migration and the establishment of intercellular contacts that support tissue architecture. However, these...
Journal Articles
J Cell Sci (2020) 133 (20): jcs244731.
Published: 30 October 2020
... the bone marrow. Here, we discuss the mechanisms of megakaryocyte differentiation and how bona fide platelets are brought into circulation. Megakaryocyte Platelet Cytoskeleton Mechanobiology Blood platelets are crucial during hemostasis to prevent hemorrhages. At sites of vascular...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (18): jcs248047.
Published: 15 September 2020
...Jana Jentzsch; Adal Sabri; Konstantin Speckner; Gertrud Lallinger-Kube; Matthias Weiss; Klaus Ersfeld ABSTRACT The shape of kinetoplastids, such as Trypanosoma brucei , is precisely defined during the stages of the life cycle and governed by a stable subpellicular microtubule cytoskeleton. During...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (15): jcs248583.
Published: 05 August 2020
... membrane mechanics during distinct developmental events. C. elegans spectrin binds to ankyrin, and these proteins function to regulate neural development. Cell migration Cytoskeleton Dendrite formation Membrane mechanics Spectrin Neural development The development of the nervous system...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (6): jcs228031.
Published: 16 March 2020
... way that cells associate with each other is through Ca 2+ -dependent adhesion molecules called cadherins, which mediate cell–cell interactions through adherens junctions, thereby anchoring and organizing the cortical actin cytoskeleton. This actin-based network confers dynamic properties to cell...
Journal Articles
J Cell Sci (2019) 132 (11): jcs224071.
Published: 31 May 2019
... moving through narrow membrane micropores were selected from established cell lines. By examining micropore-selected human MDA MB 231 breast cancer and MDA MB 435 melanoma cancer cells, membrane fluidity and nuclear elasticity were excluded as primary contributors. Instead, reduced actin cytoskeleton...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (9): jcs226266.
Published: 30 April 2019
...Hoan Van Ngo; Serge Mostowy ABSTRACT Septins are widely recognized as a component of the cytoskeleton that is essential for cell division, and new work has shown that septins can recognise cell shape by assembling into filaments on membrane regions that display micrometer-scale curvature (e.g. at...
Journal Articles
J Cell Sci (2019) 132 (9): jcs224311.
Published: 30 April 2019
... controlling cytoskeletal dynamics downstream of guidance cues, and thus, steering the axon during neuronal development. Growth cones +TIP Plus-end tracking proteins CKAP5 Cytoskeleton Super resolution F-actin alignment The growth cone is a structure at the tip of the growing axon that is...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (6): jcs229047.
Published: 15 March 2019
...-tubulin is labeled with K63 polyubiquitin chains at K304 during ciliary disassembly and transported to cell body by retrograde intraflagellar transport. Chlamydomonas Cilia Ubiquitin Cytoskeleton Organelle Intraflagellar transport Cilia/flagella are microtubule-based organelles found...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (22): jcs218099.
Published: 22 November 2018
... transport, nuclear positioning, spindle migration and anchorage, polar body extrusion and accurate chromosome segregation in mammalian oocytes. In this Cell Science at a Glance article and the accompanying poster, we summarize the many functions of the actin cytoskeleton in oocytes, with a focus on findings...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (21): jcs215517.
Published: 08 November 2018
... to the actin cytoskeleton . J. Cell Biol.   149 , 181 - 194 . 10.1083/jcb.149.1.181 Krawczyk , C. , Bachmaier , K. , Sasaki , T. , Jones , R. G. , Snapper , S. B. , Bouchard , D. , Kozieradzki , I. , Ohashi , P. S. , Alt , F. W. and Penninger , J. M...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2018) 131 (20): jcs221853.
Published: 17 October 2018
... activated by phosphorylation, provide a critical link between the plasma membrane and underlying actin cytoskeleton in surface structures. Here, we outline recent insights into how microvilli and stereocilia are built, and the roles of tip links. Furthermore, we highlight how ezrin is locally regulated by...
Journal Articles
In collection:
Cell Migration
J Cell Sci (2018) 131 (17): jcs213595.
Published: 03 September 2018
... epithelial characteristics necessary for tissue repair through regulating cytoskeleton and E-Cadherin dynamics. * Author for correspondence ( antonio.jacinto@nms.unl.pt ) Competing interests The authors declare no competing or financial interests. 5 12 2017 6 8 2018 © 2018...
Includes: Supplementary data