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Keywords: Cytochrome c
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Journal Articles
J Cell Sci (2018) 131 (16): jcs214973.
Published: 20 August 2018
... embedded within the C-terminal domain of the NAD + -dependent protein deacetylase SIRT1 is permissive for cathepsin B docking and subsequent cleavage of SIRT1. Cytochrome C Inflamm-aging SIRT1 Caspase 9 Cathepsin B Tissue aging is often accompanied by chronic, low-dose inflammation, which...
Journal Articles
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J Cell Sci (2017) 130 (2): 360–371.
Published: 15 January 2017
... polyclonal anti-caspase-9 (cat. no. 9502, 1:700; Cell Signaling), mouse monoclonal anti-cytochrome c (sc13156, 1:500; Santa Cruz), mouse monoclonal anti-PARP-1 (sc8007, 1:1000; Santa Cruz), rabbit polyclonal anti-Myc (sc789, 1:700; Santa Cruz) and rabbit polyclonal anti-calnexin (sc11397, 1:1000; Santa...
Journal Articles
Journal Articles
J Cell Sci (2008) 121 (17): 2913–2920.
Published: 1 September 2008
...Changhui Wang; Guo-Lei Zhou; Srilakshmi Vedantam; Peng Li; Jeffrey Field Mitochondria play a central role in regulating apoptosis by releasing proapoptotic contents such as cytochrome c , and generating reactive oxygen species (ROS). Early in apoptosis, proteins translocate to mitochondria...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (13): 2186–2196.
Published: 1 July 2008
..., at stage III, Bax and Bak began to form small complexes at the MOM. Later, at stage IV, these Bax and Bak complexes expanded to become large clusters. We found that the formation of Bax-Bak small complexes at stage III was responsible for permeabilizing the MOM to release cytochrome c and Smac. Using...
Includes: Multimedia, Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2005) 118 (9): 1779–1787.
Published: 1 May 2005
... and caspase activators. Despite this, studies in Caenorhabditis elegans , Drosophila and vertebrates have revealed some apparent differences both in the way apoptosis is regulated and in the way individual molecules contribute to the propagation of the death signal. For example, whereas cytochrome c released...
Journal Articles
Journal Articles
J Cell Sci (2004) 117 (13): 2641–2651.
Published: 1 June 2004
... to help sustain cell survival following damaging stimuli. (e-mail: hmbeere@aol.com ) © The Company of Biologists Limited 2004 2004 Heat shock protein (Hsp) Co-chaperones Apoptosis Apoptosome Caspases Death receptor Mitochondria Proteasome NF-κB Cytochrome c Bcl-2...
Journal Articles
J Cell Sci (2003) 116 (22): 4493–4499.
Published: 15 November 2003
... mitochondrial dysfunction and cell death. * Author for correspondence (e-mail: cwd@po.cwru.edu ) © The Company of Biologists Limited 2003 2003 Bcl-2 Endoplasmic reticulum ER Mitochondria Bcl-Cb5 Calcium BH3-only Cytochrome c Apoptosis is a cellular process by which a cell...
Journal Articles
Journal Articles
J Cell Sci (2001) 114 (4): 677–684.
Published: 15 February 2001
... in the mitochondria. It also inhibited glucose deprivation-induced cytochrome c release from the mitochondria. It is possible that overexpression of Bcl2 prevents glucose deprivation-induced ceramide generation, probably by preventing the leakage of hydroperoxide from the mitochondria. We also observed that glucose...