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Keywords: Cysteine protease
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Journal Articles
J Cell Sci (2020) 133 (1): jcs236489.
Published: 9 January 2020
... expression in the parasite. Here, we show the existence of a novel proteolytic processing for PfGCN5 that is crucial for its activity in vivo . We find that a cysteine protease-like enzyme is required for the processing of PfGCN5 protein. Immunofluorescence and immuno-electron microscopy analysis suggest...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2000) 113 (22): 4035–4041.
Published: 15 November 2000
...Darren R. Brooks; Laurence Tetley; Graham H. Coombs; Jeremy C. Mottram ABSTRACT Removal of the pro-domain of a cysteine protease is essential for activation of the enzyme. We have engineered a cysteine protease (CPB2.8) of the protozoan parasite Leishmania mexicana by site-directed mutagenesis...
Journal Articles
J Cell Sci (1995) 108 (10): 3219–3231.
Published: 1 October 1995
..., or if amastigotes were pre-treated with the irreversible cysteine protease inhibitor Z-Phe-AlaCHN2 before infection, clearly indicating that amastigotes also degraded the internalized class II molecules. Study of infected macrophage cryosections by immuno-electron microscopy allowed the identification of the class...
Journal Articles