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Keywords: Cyclin-dependent kinase
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Journal Articles
In collection:
Cell Cycle , Metabolism
J Cell Sci (2023) 136 (10): jcs260727.
Published: 25 May 2023
... repressed state essential for cell survival in stressful environments. In the fission yeast Schizosaccharomyces pombe , cell size is reduced by cell division before entry into stationary phase; thus cyclin-dependent kinase (CDK) must actively contribute to stationary phase establishment. However...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (12): jcs259626.
Published: 21 June 2022
...Souradeep Basu; James O. Patterson; Theresa U. Zeisner; Paul Nurse ABSTRACT The eukaryotic cell cycle is driven by the activity of cyclin-dependent kinases (CDKs). CDK activity rises over 50-fold during the cell cycle, from a low level in G1 to a high level in mitosis. However, it is not known...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (6): jcs235721.
Published: 17 March 2020
...Yang Ma; Guanxiong Yan; Xiaojie Han; Jing Zhang; Jie Xiong; Wei Miao ABSTRACT To investigate the mechanisms underlying initiation of the sexual cell cycle in eukaryotes, we have focused on cyclins and cyclin-dependent kinases (CDKs) in the well-studied model ciliate, Tetrahymena thermophila . We...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (18): jcs232314.
Published: 23 September 2019
... medium provided that the original work is properly attributed. Summary: Phosphorylation of importin-α1 by cyclin-dependent kinase 1 provides spatial and temporal control of mitotic spindle assembly through the release of spindle-assembly factors from inhibitory complexes during mitosis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (16): 2673–2681.
Published: 15 August 2017
...Brendan L. Powers; Mark C. Hall ABSTRACT Inactivation of cyclin-dependent kinase (Cdk) and reversal of Cdk phosphorylation are universally required for mitotic exit. In budding yeast ( Saccharomyces cerevisiae ), Cdc14 is essential for both and thought to be the major Cdk-counteracting phosphatase...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (20): 4703–4711.
Published: 15 October 2012
...Daniel Fisher; Liliana Krasinska; Damien Coudreuse; Béla Novák Summary Fifteen years ago, it was proposed that the cell cycle in fission yeast can be driven by quantitative changes in the activity of a single protein kinase complex comprising a cyclin – namely cyclin B – and cyclin dependent kinase...
Journal Articles
J Cell Sci (2012) 125 (10): 2533–2543.
Published: 15 May 2012
...Chang-Run Li; Jie-Ying Au Yong; Yan-Ming Wang; Yue Wang Cyclin-dependent kinases (CDKs) regulate septin organization in a cell-cycle-dependent manner in yeast. However, the mechanism remains unclear. Here, we show that the Candida albicans CDK Cdc28 phosphorylates the Nim1-related kinase Gin4...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (14): 2424–2434.
Published: 15 July 2007
...Dongli Hu; Marcus Valentine; Vincent J. Kidd; Jill M. Lahti Cyclin-dependent kinase 11 (CDK11) mRNA produces a 110-kDa protein (CDK11 p110 ) throughout the cell cycle and a 58-kDa protein (CDK11 p58 ) that is specifically translated from an internal ribosome entry site sequence during G2/M. CDK11...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2007) 120 (3): 435–446.
Published: 1 February 2007
...Stephen M. Huisman; Monique F. M. A. Smeets; Marisa Segal Spindle morphogenesis is regulated by cyclin-dependent kinases and monitored by checkpoint pathways to accurately coordinate chromosomal segregation with other events in the cell cycle. We have previously dissected the contribution...
Includes: Supplementary data
Journal Articles
J Cell Sci (2004) 117 (18): 4089–4098.
Published: 15 August 2004
...Chun Y. Gao; Mary Ann Stepp; Robert Fariss; Peggy Zelenka Recent studies have shown that Cdk5, a member of the cyclin-dependent-kinase family, regulates adhesion and migration in a mouse corneal epithelial cell line. Here, we extend these findings to corneal wound healing in vivo and examine...
Journal Articles
J Cell Sci (2004) 117 (3): 487–506.
Published: 22 January 2004
...Tatiana García-Muse; Gero Steinberg; José Pérez-Martín Pathogenesis, morphogenesis and cell cycle are connected in the fungal pathogen Ustilago maydis . Here we report the characterization of the catalytic subunit of the cyclin-dependent kinase, encoded by the gene cdk1 , and the two B-type...
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (1998) 111 (24): 3585–3596.
Published: 18 December 1998
...Philipp Kaldis; Zachary W. Pitluk; I. Amy Bany; Deborah A. Enke; Marisa Wagner; Edward Winter; Mark J. Solomon ABSTRACT Eukaryotic cell cycles are controlled by the activities of cyclin-dependent kinases (cdks). The major cdk in budding yeast, Saccharomyces cerevisiae , is Cdc28p. Activation...
Journal Articles
Journal Articles
J Cell Sci (1995) 108 (6): 2425–2432.
Published: 1 June 1995
... association with subcellular structures may play key regulatory roles at different stages of the cell cycle and during mitosis. * Author for correspondence 30 09 1994 02 03 1995 © 1995 by Company of Biologists 1995 wee1 cyclin-dependent kinase cell cycle mitosis...
Journal Articles
J Cell Sci (1994) 107 (10): 2789–2799.
Published: 1 October 1994
..., and that the activation of p40 MO15 may require phosphorylation on T176. * Author for correspondence 11 05 1994 10 06 1994 © 1994 by Company of Biologists 1994 CAK cell cycle cyclin-dependent kinase Fig. 7. Phosphorylation and activation of GST-MO15 mutants. (A) Xenopus CSF...
Journal Articles
J Cell Sci (1994) 1994 (Supplement_18): 89–96.
Published: 1 January 1994
... by chromosomal translocation, DNA amplification and retroviral integration. Cyclins D1, D2 and D3 preferentially associate with two closely related members of the cyclin-dependent kinase family, Cdk4 and Cdk6 and the various complexes are each capable of phosphorylating the retinoblastoma gene product (pRb...
Journal Articles
J Cell Sci (1993) 106 (2): 535–544.
Published: 1 October 1993
... that deletion of the C terminus might create completely non-functional cyclin A proteins. Neither Kobayashi et al. (1992) nor Lees and Harlow (1993) have studied the subcellular localization of cyclin A. cyclin cdk cyclin-dependent kinase complex formation nuclear transport Cyclin proteins...