... repressed state essential for cell survival in stressful environments. In the fission yeast Schizosaccharomyces pombe , cell size is reduced by cell division before entry into stationary phase; thus cyclin-dependent kinase (CDK) must actively contribute to stationary phase establishment. However...

...Souradeep Basu; James O. Patterson; Theresa U. Zeisner; Paul Nurse ABSTRACT The eukaryotic cell cycle is driven by the activity of cyclin-dependent kinases (CDKs). CDK activity rises over 50-fold during the cell cycle, from a low level in G1 to a high level in mitosis. However, it is not known...

...Yang Ma; Guanxiong Yan; Xiaojie Han; Jing Zhang; Jie Xiong; Wei Miao ABSTRACT To investigate the mechanisms underlying initiation of the sexual cell cycle in eukaryotes, we have focused on cyclins and cyclin-dependent kinases (CDKs) in the well-studied model ciliate, Tetrahymena thermophila . We...

... medium provided that the original work is properly attributed. Summary: Phosphorylation of importin-α1 by cyclin-dependent kinase 1 provides spatial and temporal control of mitotic spindle assembly through the release of spindle-assembly factors from inhibitory complexes during mitosis...

...Brendan L. Powers; Mark C. Hall ABSTRACT Inactivation of cyclin-dependent kinase (Cdk) and reversal of Cdk phosphorylation are universally required for mitotic exit. In budding yeast ( Saccharomyces cerevisiae ), Cdc14 is essential for both and thought to be the major Cdk-counteracting phosphatase...

...Daniel Fisher; Liliana Krasinska; Damien Coudreuse; Béla Novák Summary Fifteen years ago, it was proposed that the cell cycle in fission yeast can be driven by quantitative changes in the activity of a single protein kinase complex comprising a cyclin – namely cyclin B – and cyclin dependent kinase...

...Chang-Run Li; Jie-Ying Au Yong; Yan-Ming Wang; Yue Wang Cyclin-dependent kinases (CDKs) regulate septin organization in a cell-cycle-dependent manner in yeast. However, the mechanism remains unclear. Here, we show that the Candida albicans CDK Cdc28 phosphorylates the Nim1-related kinase Gin4...

...Dongli Hu; Marcus Valentine; Vincent J. Kidd; Jill M. Lahti Cyclin-dependent kinase 11 (CDK11) mRNA produces a 110-kDa protein (CDK11 p110 ) throughout the cell cycle and a 58-kDa protein (CDK11 p58 ) that is specifically translated from an internal ribosome entry site sequence during G2/M. CDK11...

...Stephen M. Huisman; Monique F. M. A. Smeets; Marisa Segal Spindle morphogenesis is regulated by cyclin-dependent kinases and monitored by checkpoint pathways to accurately coordinate chromosomal segregation with other events in the cell cycle. We have previously dissected the contribution...

...Chun Y. Gao; Mary Ann Stepp; Robert Fariss; Peggy Zelenka Recent studies have shown that Cdk5, a member of the cyclin-dependent-kinase family, regulates adhesion and migration in a mouse corneal epithelial cell line. Here, we extend these findings to corneal wound healing in vivo and examine...

...Tatiana García-Muse; Gero Steinberg; José Pérez-Martín Pathogenesis, morphogenesis and cell cycle are connected in the fungal pathogen Ustilago maydis . Here we report the characterization of the catalytic subunit of the cyclin-dependent kinase, encoded by the gene cdk1 , and the two B-type...

...Anabelle Decottignies; Patrick Zarzov; Paul Nurse We investigated the in vivo localisation of fission yeast cyclin-dependent kinase cdc2p during mitosis and meiosis. Fusion to yellow fluorescent protein (YFP) revealed that cdc2-YFP is present in the cytoplasm at all stages of the cell cycle...

... of Biologists 2000 Cdc6 Proteolysis S phase Cyclin-dependent kinase Duplication of nuclear DNA is strictly coordinated with the rest of the cell cycle so that it occurs only once before the cycle is reset at mitosis. Regulated initiation of mammalian DNA replication can now be achieved...

...Philipp Kaldis; Zachary W. Pitluk; I. Amy Bany; Deborah A. Enke; Marisa Wagner; Edward Winter; Mark J. Solomon ABSTRACT Eukaryotic cell cycles are controlled by the activities of cyclin-dependent kinases (cdks). The major cdk in budding yeast, Saccharomyces cerevisiae , is Cdc28p. Activation...

...Jean-Bernard Lazaro; Magali Kitzmann; Marie-Alix Poul; Marie Vandromme; Ned J. C. Lamb; Anne Fernandez ABSTRACT We have examined the expression, activity and localization of cyclin dependent kinase 5 (cdk5), during myogenesis. Cdk5 protein was found expressed in adult mouse muscle. In murine C2...

... association with subcellular structures may play key regulatory roles at different stages of the cell cycle and during mitosis. * Author for correspondence 30 09 1994 02 03 1995 © 1995 by Company of Biologists 1995 wee1 cyclin-dependent kinase cell cycle mitosis...

..., and that the activation of p40 MO15 may require phosphorylation on T176. * Author for correspondence 11 05 1994 10 06 1994 © 1994 by Company of Biologists 1994 CAK cell cycle cyclin-dependent kinase Fig. 7. Phosphorylation and activation of GST-MO15 mutants. (A) Xenopus CSF...

... by chromosomal translocation, DNA amplification and retroviral integration. Cyclins D1, D2 and D3 preferentially associate with two closely related members of the cyclin-dependent kinase family, Cdk4 and Cdk6 and the various complexes are each capable of phosphorylating the retinoblastoma gene product (pRb...

... that deletion of the C terminus might create completely non-functional cyclin A proteins. Neither Kobayashi et al. (1992) nor Lees and Harlow (1993) have studied the subcellular localization of cyclin A. cyclin cdk cyclin-dependent kinase complex formation nuclear transport Cyclin proteins...