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1-20 of 20
Keywords: Cyclin-dependent kinase
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Journal Articles
Motoaki Hiraoka, Yuki Kiyota, Shinnosuke Kawai, Yusuke Notsu, Kohei Yamada, Katsuyuki Kurashima, Jing-Wen Chang, Shunsuke Shimazaki, Ayumu Yamamoto
Journal:
Journal of Cell Science
J Cell Sci (2023) 136 (10): jcs260727.
Published: 25 May 2023
... repressed state essential for cell survival in stressful environments. In the fission yeast Schizosaccharomyces pombe , cell size is reduced by cell division before entry into stationary phase; thus cyclin-dependent kinase (CDK) must actively contribute to stationary phase establishment. However...
Includes: Supplementary data
Journal Articles
A CDK activity buffer ensures mitotic completion
Open AccessIn collection:
Nuclear structure and function
Journal:
Journal of Cell Science
J Cell Sci (2022) 135 (12): jcs259626.
Published: 21 June 2022
...Souradeep Basu; James O. Patterson; Theresa U. Zeisner; Paul Nurse ABSTRACT The eukaryotic cell cycle is driven by the activity of cyclin-dependent kinases (CDKs). CDK activity rises over 50-fold during the cell cycle, from a low level in G1 to a high level in mitosis. However, it is not known...
Includes: Supplementary data
Journal Articles
Sexual cell cycle initiation is regulated by CDK19 and CYC9 in Tetrahymena thermophila
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (2020) 133 (6): jcs235721.
Published: 17 March 2020
...Yang Ma; Guanxiong Yan; Xiaojie Han; Jing Zhang; Jie Xiong; Wei Miao ABSTRACT To investigate the mechanisms underlying initiation of the sexual cell cycle in eukaryotes, we have focused on cyclins and cyclin-dependent kinases (CDKs) in the well-studied model ciliate, Tetrahymena thermophila . We...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2019) 132 (18): jcs232314.
Published: 23 September 2019
... medium provided that the original work is properly attributed. Summary: Phosphorylation of importin-α1 by cyclin-dependent kinase 1 provides spatial and temporal control of mitotic spindle assembly through the release of spindle-assembly factors from inhibitory complexes during mitosis...
Includes: Supplementary data
Journal Articles
Re-examining the role of Cdc14 phosphatase in reversal of Cdk phosphorylation during mitotic exit
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (2017) 130 (16): 2673–2681.
Published: 15 August 2017
...Brendan L. Powers; Mark C. Hall ABSTRACT Inactivation of cyclin-dependent kinase (Cdk) and reversal of Cdk phosphorylation are universally required for mitotic exit. In budding yeast ( Saccharomyces cerevisiae ), Cdc14 is essential for both and thought to be the major Cdk-counteracting phosphatase...
Includes: Supplementary data
Journal Articles
Phosphorylation network dynamics in the control of cell cycle transitions
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (2012) 125 (20): 4703–4711.
Published: 15 October 2012
...Daniel Fisher; Liliana Krasinska; Damien Coudreuse; Béla Novák Summary Fifteen years ago, it was proposed that the cell cycle in fission yeast can be driven by quantitative changes in the activity of a single protein kinase complex comprising a cyclin – namely cyclin B – and cyclin dependent kinase...
Journal Articles
CDK regulates septin organization through cell-cycle-dependent phosphorylation of the Nim1-related kinase Gin4
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (2012) 125 (10): 2533–2543.
Published: 15 May 2012
...Chang-Run Li; Jie-Ying Au Yong; Yan-Ming Wang; Yue Wang Cyclin-dependent kinases (CDKs) regulate septin organization in a cell-cycle-dependent manner in yeast. However, the mechanism remains unclear. Here, we show that the Candida albicans CDK Cdc28 phosphorylates the Nim1-related kinase Gin4...
Includes: Supplementary data
Journal Articles
CDK11 p58 is required for the maintenance of sister chromatid cohesion
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (2007) 120 (14): 2424–2434.
Published: 15 July 2007
...Dongli Hu; Marcus Valentine; Vincent J. Kidd; Jill M. Lahti Cyclin-dependent kinase 11 (CDK11) mRNA produces a 110-kDa protein (CDK11 p110 ) throughout the cell cycle and a 58-kDa protein (CDK11 p58 ) that is specifically translated from an internal ribosome entry site sequence during G2/M. CDK11...
Includes: Multimedia, Supplementary data
Journal Articles
Phosphorylation of Spc110p by Cdc28p-Clb5p kinase contributes to correct spindle morphogenesis in S. cerevisiae
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (2007) 120 (3): 435–446.
Published: 1 February 2007
...Stephen M. Huisman; Monique F. M. A. Smeets; Marisa Segal Spindle morphogenesis is regulated by cyclin-dependent kinases and monitored by checkpoint pathways to accurately coordinate chromosomal segregation with other events in the cell cycle. We have previously dissected the contribution...
Includes: Supplementary data
Journal Articles
Cdk5 regulates activation and localization of Src during corneal epithelial wound closure
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (2004) 117 (18): 4089–4098.
Published: 15 August 2004
...Chun Y. Gao; Mary Ann Stepp; Robert Fariss; Peggy Zelenka Recent studies have shown that Cdk5, a member of the cyclin-dependent-kinase family, regulates adhesion and migration in a mouse corneal epithelial cell line. Here, we extend these findings to corneal wound healing in vivo and examine...
Journal Articles
Characterization of B-type cyclins in the smut fungus Ustilago maydis : roles in morphogenesis and pathogenicity
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (2004) 117 (3): 487–506.
Published: 22 January 2004
...Tatiana García-Muse; Gero Steinberg; José Pérez-Martín Pathogenesis, morphogenesis and cell cycle are connected in the fungal pathogen Ustilago maydis . Here we report the characterization of the catalytic subunit of the cyclin-dependent kinase, encoded by the gene cdk1 , and the two B-type...
Journal Articles
In vivo localisation of fission yeast cyclin-dependent kinase cdc2p and cyclin B cdc13p during mitosis and meiosis
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (2001) 114 (14): 2627–2640.
Published: 15 July 2001
...Anabelle Decottignies; Patrick Zarzov; Paul Nurse We investigated the in vivo localisation of fission yeast cyclin-dependent kinase cdc2p during mitosis and meiosis. Fusion to yellow fluorescent protein (YFP) revealed that cdc2-YFP is present in the cytoplasm at all stages of the cell cycle...
Journal Articles
Chromatin-bound Cdc6 persists in S and G 2 phases in human cells, while soluble Cdc6 is destroyed in a cyclin A-cdk2 dependent process
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Journal:
Journal of Cell Science
J Cell Sci (2000) 113 (11): 1929–1938.
Published: 1 June 2000
... associated with yeast replication origins in cyclin-dependent kinase (cdk) mutants, and of the behaviour of the Mcm proteins in the presence of protein kinase inhibitors in mammalian cells ( Coverley et al., 1998 ; Dahmann et al., 1995 ; Piatti et al., 1996 ), suggest that phosphorylation events...
Journal Articles
Localization and regulation of the cdk-activating kinase (Cak1p) from budding yeast
Available to PurchasePhilipp Kaldis, Zachary W. Pitluk, I. Amy Bany, Deborah A. Enke, Marisa Wagner, Edward Winter, Mark J. Solomon
Journal:
Journal of Cell Science
J Cell Sci (1998) 111 (24): 3585–3596.
Published: 18 December 1998
...Philipp Kaldis; Zachary W. Pitluk; I. Amy Bany; Deborah A. Enke; Marisa Wagner; Edward Winter; Mark J. Solomon ABSTRACT Eukaryotic cell cycles are controlled by the activities of cyclin-dependent kinases (cdks). The major cdk in budding yeast, Saccharomyces cerevisiae , is Cdc28p. Activation...
Journal Articles
Cyclin dependent kinase 5, cdk5, is a positive regulator of myogenesis in mouse C2 cells
Available to PurchaseJean-Bernard Lazaro, Magali Kitzmann, Marie-Alix Poul, Marie Vandromme, Ned J. C. Lamb, Anne Fernandez
Journal:
Journal of Cell Science
J Cell Sci (1997) 110 (10): 1251–1260.
Published: 15 May 1997
...Jean-Bernard Lazaro; Magali Kitzmann; Marie-Alix Poul; Marie Vandromme; Ned J. C. Lamb; Anne Fernandez ABSTRACT We have examined the expression, activity and localization of cyclin dependent kinase 5 (cdk5), during myogenesis. Cdk5 protein was found expressed in adult mouse muscle. In murine C2...
Journal Articles
Subcellular localisation of human wee1 kinase is regulated during the cell cycle
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (1995) 108 (6): 2425–2432.
Published: 1 June 1995
... kinase activity is required to shut off already activated cyclin-dependent kinase complexes or to protect a sub-population of a specific cdk complex from being activated. The assembly of the contractile structures necessary for cytokinesis and the stabilisation of polar microtubules might therefore...
Journal Articles
Regulation of Cdc2/cyclin B activation by Ran, a Ras-related GTPase
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Journal:
Journal of Cell Science
J Cell Sci (1995) 108 (3): 1217–1225.
Published: 1 March 1995
... checkpoint cyclin-dependent kinase mitosis In the past few years, significant advances have been made in understanding the molecular mechanism controlling the pro-gression of the eukaryotic cell cycle ( Murray and Hunt, 1993 ). Central components of this mechanism are the cyclin-dependent protein...
Journal Articles
Cell cycle regulation of the p34 cdc2 /p33 cdk2 -activating kinase p40 MO15
Available to PurchaseRandy Y. C. Poon, Katsumi Yamashita, Michael Howell, Maxim A. Ershler, Alexander Belyavsky, Tim Hunt
Journal:
Journal of Cell Science
J Cell Sci (1994) 107 (10): 2789–2799.
Published: 1 October 1994
..., and that the activation of p40 MO15 may require phosphorylation on T176. * Author for correspondence 11 05 1994 10 06 1994 © 1994 by Company of Biologists 1994 CAK cell cycle cyclin-dependent kinase Cyclins and cyclin-dependent kinases (CDKs) are key regulators of the eukaryotic...
Journal Articles
The D-type cyclins and their role in tumorigenesis
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (1994) 1994 (Supplement_18): 89–96.
Published: 1 January 1994
...-mosomal translocation, DNA amplification and retroviral integration. Cyclins DI, D2 and D3 preferentially associate with two closely related members of the cyclin-dependent kinase family, Cdk4 and Cdk6 and the various complexes are each capable of phosphorylating the retinoblastoma gene product (pRb...
Journal Articles
Nuclear localization of vertebrate cyclin a correlates with its ability to form complexes with cdk catalytic subunits
Available to Purchase
Journal:
Journal of Cell Science
J Cell Sci (1993) 106 (2): 535–544.
Published: 1 October 1993
... subjected to SDS-PAGE or washed once more in kinase assay buffer ( Krek and Nigg, 1991 ) and used for histone H1 kinase assays. * Author for correspondence 31 05 1993 06 06 1993 © 1993 by Company of Biologists 1993 cyclin cdk cyclin-dependent kinase complex formation...