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Keywords: Cotransporter
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Journal Articles
J Cell Sci (2008) 121 (5): 675–684.
Published: 1 March 2008
... effectively by thiazide diuretics, which exert their effects by inhibiting the Na + -Cl – cotransporter (NCC), suggesting a link between WNK1 and NCC. Here, we demonstrate that the SPAK and OSR1 kinases that are activated by WNK1 phosphorylate human NCC at three conserved residues (Thr46, Thr55 and Thr60...