...Svetlana Lutsenko ABSTRACT Copper (Cu) homeostasis is essential for the development and function of many organisms. In humans, Cu misbalance causes serious pathologies and has been observed in a growing number of diseases. This Review focuses on mammalian Cu(I) transporters and highlights recent...

...: Excess Cu + induces the transport of ATP7B from the TGN to the membrane of the bile canaliculus through basolateral sorting and transcytosis for biliary Cu + excretion without lysosomal involvement. Copper ATP7B Trafficking TGN Bile canaliculus Transcytosis Fondo de Investigaciones...

..., with amelioration when copper bound. Amino acid residues 23-50 alone mediated a ROS reduction response. PrP23-50 ROS reduction was not due to copper binding or direct antioxidant activity, but was instead mediated through proteoglycan binding partners localised in or interacting with cholesterol-rich membrane...

...Carine White; Taiho Kambe; Yan G. Fulcher; Sherri W. Sachdev; Ashley I. Bush; Kevin Fritsche; Jaekwon Lee; Thomas P. Quinn; Michael J. Petris Copper is an essential nutrient for a variety of biochemical processes; however, the redox properties of copper also make it potentially toxic in the free...

... of its internalisation is unclear, with both raft/caveolae-based and clathrin-mediated processes being proposed. We have investigated the mechanism of copper-induced internalisation of PrP C in neuronal cells by immunofluorescence microscopy, surface biotinylation assays and buoyant sucrose density...

... Mol. Biol. 21 , 746 -752. Brewer, G. J. (2001). Copper control as an antiangiogenic anticancer therapy: lessons from treating Wilson's disease. Exp. Biol. Med. 226 , 665 -673. Brewer, G. J., Dick, R. D., Grover, D. K., LeClaire, V., Tseng, M., Wicha, M., Pienta, K., Redman, B. G...

...Anna Mandinova; Raffaella Soldi; Irene Graziani; Cinzia Bagalá; Stephen Bellum; Matteo Landriscina; Francesca Tarantini; Igor Prudovsky; Thomas Maciag Copper is involved in the promotion of angiogenic and inflammatory events in vivo and, although recent clinical data has demonstrated the potential...

...E. Piccinni; P. Irato; O. Coppellotti; L. Guidolin ABSTRACT The addition of copper (10 μ gml −1) or cadmium (5 μ gml −1) to the medium is well tolerated by Tetrahymena pyriformis GL. Both metals are accumulated by cells, cadmium to a greater extent than copper. The growth rate is not affected...