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Keywords: Contractility
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Journal Articles
In collection:
Cytoskeleton , Polarity
J Cell Sci (2022) 135 (3): jcs258921.
Published: 8 February 2022
...Imge Ozugergin; Karina Mastronardi; Chris Law; Alisa Piekny ABSTRACT Cytokinesis occurs at the end of mitosis as a result of the ingression of a contractile ring that cleaves the daughter cells. The core machinery regulating this crucial process is conserved among metazoans. Multiple pathways...
Includes: Supplementary data
Journal Articles
In collection:
Cell Migration
J Cell Sci (2021) 134 (17): jcs258767.
Published: 2 September 2021
...-mediated junctional contractility. We found that active RhoA levels were stimulated by p114 RhoGEF (also known as ARHGEF18) at the junctions between migrating MCF-7 monolayers, and this was accompanied by increased levels of actomyosin and mechanical tension. Applying a strategy to restore active RhoA...
Includes: Supplementary data
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2021) 134 (6): jcs240226.
Published: 22 March 2021
... an overview of the morphology and structure of pericytes, we describe their interactions with both the basement membrane and endothelial cells. We then turn our attention to biophysical considerations, and describe contractile forces generated by pericytes, mechanical forces exerted on pericytes, and pericyte...
Journal Articles
In collection:
Adhesion
J Cell Sci (2020) 133 (13): jcs235622.
Published: 6 July 2020
... not substantively alter the balance of epithelial and mesenchymal genes. However, we identified a transcriptional network that led to upregulated RhoA signalling and cortical contractility in cells expressing Snail 6SA . Enhanced contractility was necessary, but not sufficient, to drive extrusion, suggesting...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (24): jcs236828.
Published: 13 December 2019
... of actomyosin-based contractility. We propose that these newly identified features are instrumental for the ability of podosomes to generate protrusion forces and to mechanically probe their environment. Furthermore, these new results point to an increasing complexity of podosome architecture and have led...
Journal Articles
J Cell Sci (2018) 131 (24): jcs203570.
Published: 18 December 2018
.... For example, how does a disordered cytoskeletal network transform into a coherent ring? What are the long-distance effects of localized contractility? Here, we provide a general introduction to ‘modeling for biologists’, and review how agent-based modeling and continuum mechanics modeling have helped...
Journal Articles
J Cell Sci (2018) 131 (14): jcs186254.
Published: 19 July 2018
... ). Reassembly of contractile actin cortex in cell blebs . J. Cell Biol.   175 , 477 - 490 . 10.1083/jcb.200602085 Charras , G. T. , Coughlin , M. , Mitchison , T. J. and Mahadevan , L. ( 2008 ). Life and times of a cellular bleb . Biophys. J.   94 , 1836 - 1853 . 10.1529/biophysj...
Includes: Supplementary data
Journal Articles
In collection:
Cell Migration
J Cell Sci (2018) 131 (3): jcs209361.
Published: 8 February 2018
... binding. In polarized cells, ACTN1 was found to be enriched at the tight junction where it acts as a primary effector of EFA6A for normal luminogenesis. Both proteins are essential for the lumen extension and enlargement, where they mediate their effect by regulating the cortical acto-myosin contractility...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (1): 63–70.
Published: 1 January 2017
... stem cells (ESCs) ( Sargent et al., 2009 ) and, more recently, iPSCs ( Beauchamp et al., 2015 ). A hallmark of differentiated cardiac cells is the formation of sarcomeres, the fundamental contractile unit of cardiomyocytes, and ensuing spontaneous beating. Unlike heart muscle tissue, cellular and ECM...
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2016) 129 (1): 80–94.
Published: 1 January 2016
... molecularly uncoupled p120's cadherin-stabilizing and RhoA-suppressing activites. Unexpectedly, removing p120's Rho-suppressing activity dramatically disrupted the integrity of the apical surface, irrespective of E-cadherin stability. The physical defect was tracked to excessive actomyosin contractility along...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (12): 2209–2217.
Published: 15 June 2015
...Ronen Zaidel-Bar; Guo Zhenhuan; Chen Luxenburg ABSTRACT Actomyosin contractility is a highly regulated process that affects many fundamental biological processes in each and every cell in our body. In this Cell Science at a Glance article and the accompanying poster, we mined the literature...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (7): 1379–1393.
Published: 1 April 2014
.../journal.pbio.0050317 Zhang   X-F. , Schaefer   A. W. , Burnette   D. T. , Schoonderwoert   V. T. , Forscher   P. ( 2003 ). Rho-dependent contractile responses in the neuronal growth cone are independent of classical peripheral retrograde actin flow.   Neuron   40 , 931 – 944 . 10.1016...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (13): 3051–3060.
Published: 1 July 2012
... that complements the structural changes affected by regulatory systems in response to mechanical processes. * Authors for correspondence ( ulrich.schwarz@bioquant.uni-heidelberg.de ; gardel@uchicago.edu ) © 2012. Published by The Company of Biologists Ltd 2012 Actin Cell adhesion Contractility...
Journal Articles
J Cell Sci (2012) 125 (9): 2244–2256.
Published: 1 May 2012
... undergoes slower retrograde flow than the actin that is present in 2D lamellipodia. These data suggest an increase in mechanical coupling between adhesions and protrusive machinery. Experimental reduction of contractility resulted in the loss of 1D adhesion structure and stability, with scattered small...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2011) 124 (4): 635–646.
Published: 15 February 2011
... myosin contractility and F-actin polymerization. Furthermore, we find that the non-canonical Wnt-signaling pathway permissively regulates levels of punctuated actin contractions. Overexpression of Xfz7 (Fzd7) can induce early maturation of actin contractions in mesoderm and produce mesoderm-like actin...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2010) 123 (5): 712–722.
Published: 1 March 2010
... ROCK, MLCK and myosin ATPase II activity. The regulation of intercellular adhesion strength by integrin stimulation required activation of Src family kinases, ROCK and actomyosin contractility. These findings highlight the importance and mechanisms of molecular crosstalk between cadherins and integrins...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2010) 123 (3): 384–391.
Published: 1 February 2010
... to this work ‡ Author for correspondence ( granzier@email.arizona.edu ) 23 11 2009 © 2010. 2010 Muscle Cytoskeleton Contractility Sarcomeric structure Nemaline myopathy The sarcomere is the basic contractile unit of striated muscle, and is composed of highly ordered thin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (12): 2119–2126.
Published: 15 June 2009
... that promote rapid actin dynamics are also expressed in striated muscles. We show that a subset of actin filaments in cardiomyocyte sarcomeres displays rapid turnover. Importantly, we found that turnover of these filaments depends on contractility of the cardiomyocytes. Studies using an actin-polymerization...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2007) 120 (20): 3491–3499.
Published: 15 October 2007
...Stéphanie Pellegrin; Harry Mellor Animal cell movement is effected through a combination of protrusive and contractile events. Non-muscle cells contain stress fibres – bundles of actomyosin that are the major mediators of cell contraction and that can be compared to the highly organised actomyosin...
Journal Articles
J Cell Sci (1988) 90 (3): 351–364.
Published: 1 July 1988
...+ -binding proteins from the microfibrillar ectoplasmic-endoplasmic boundary of Isotricha and to beselectively solubilized in the presence of EGTA. The possibility that the ICL may be a new example of a non-actin contractile system foundin lower eukaryotes is discussed. cytoskeleton Paramecium...