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Keywords: Connexin43
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Journal Articles
J Cell Sci (2020) 133 (5): jcs237925.
Published: 10 March 2020
... of BCR signaling include reorganization of actin and membrane spreading, which facilitates increased antigen gathering. We have previously shown that the gap junction protein connexin43 (Cx43; also known as GJA1) is phosphorylated upon BCR signaling, and its carboxyl tail (CT) is important for BCR...
Journal Articles
J Cell Sci (2014) 127 (15): 3269–3279.
Published: 01 August 2014
... downstream effects on cellular processes. Here, we identify an interaction between the T-cell protein tyrosine phosphatase (TC-PTP, officially known as PTPN2) and the carboxyl terminus of connexin43 (Cx43, officially known as GJA1). Two cell lines, normal rat kidney (NRK) cells endogenously expressing Cx43...
Journal Articles
J Cell Sci (2014) 127 (2): 455–464.
Published: 15 January 2014
...Clarence A. Dunn; Paul D. Lampe ABSTRACT The proteins that form vertebrate gap junctions, the connexins, are highly regulated and have short (<2 hour) half-lives. Phosphorylation of connexin43 (Cx43) affects gap junction assembly, channel gating and turnover. After finding dramatic effects...
Journal Articles
J Cell Sci (2012) 125 (17): 3966–3976.
Published: 01 September 2012
... channels are made of a family of integral membrane proteins called connexins, of which the best-studied member is connexin43. Gap junctions are dynamic plasma membrane domains, and connexin43 has a high turnover rate in most tissue types. However, the mechanisms involved in the regulation of connexin43...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2012) 125 (4): 1058–1067.
Published: 15 February 2012
... , 10213 - 10218 . Maass K. , Shibayama J. , Chase S. E. , Willecke K. , Delmar M. ( 2007 ). C-terminal truncation of connexin43 changes number, size, and localization of cardiac gap junction plaques . Circ. Res. 101 , 1283 - 1291 . Massey K. D. , Minnich...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (15): 2611–2621.
Published: 01 August 2011
...Steven Machtaler; May Dang-Lawson; Kate Choi; Caren Jang; Christian C. Naus; Linda Matsuuchi The gap junction protein connexin43 (Cx43) is widely expressed in mammalian cells and forms intercellular channels for the transfer of small molecules between adjacent cells, as well as hemichannels...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (24): 4029–4036.
Published: 15 December 2008
... and induced a G2-M arrest in ANSCs. Using Fluo-3 Ca 2+ imaging, we show that AQP4 knockout alters the spontaneous Ca 2+ oscillations by frequency enhancement and amplitude suppression, and suppresses KCl-induced Ca 2+ influx. AQP4 knockout downregulated the expression of connexin43 and the L-type voltage...
Journal Articles
J Cell Sci (2006) 119 (24): 5193–5203.
Published: 15 December 2006
...Ryoichi Mori; Kieran T. Power; Chiuhui Mary Wang; Paul Martin; David L. Becker Experimental downregulation of connexin43 (Cx43) expression at skin wound sites appears to markedly improve the rate and quality of healing, but the underlying mechanisms are currently unknown. Here, we have compared...
Journal Articles
J Cell Sci (2006) 119 (21): 4510–4519.
Published: 01 November 2006
...Mónica R. Calera; Heather L. Topley; Yongbo Liao; Brian R. Duling; David L. Paul; Daniel A. Goodenough Connexin43 is a major component of the gap junctions between pigmented and non-pigmented cells of the double-layered epithelium in the ciliary body of the eye. We directly tested the hypothesis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (20): 4187–4198.
Published: 15 October 2006
...Dong Jin Chung; Charlles H. M. Castro; Marcus Watkins; Joseph P. Stains; Min Young Chung; Vera Lucia Szejnfeld; Klaus Willecke; Martin Theis; Roberto Civitelli Connexin43 (Cx43) is involved in bone development, but its role in adult bone homeostasis remains unknown. To overcome the postnatal...
Journal Articles
J Cell Sci (2006) 119 (16): 3435–3442.
Published: 15 August 2006
...Paul D. Lampe; Cynthia D. Cooper; Timothy J. King; Janis M. Burt The functional consequences of Connexin43 (Cx43) phosphorylation remain largely unexplored. Using an antibody that specifically recognizes Cx43 phosphorylated at serine residues 325, 328 and/or 330 (pS325/328/330-Cx43), we show...
Journal Articles
J Cell Sci (2006) 119 (3): 532–541.
Published: 01 February 2006
...Albert Lai; Dung-Nghi Le; William A. Paznekas; Wes D. Gifford; Ethylin Wang Jabs; Andrew C. Charles Oculodentodigital dysplasia (ODDD) is a rare developmental disorder characterized by craniofacial and limb abnormalities. Over 35 separate mutations in human connexin43 (Cx43) causing ODDD have been...
Journal Articles
J Cell Sci (2005) 118 (1): 113–122.
Published: 01 January 2005
...Joanne E. I. Gittens; Kevin J. Barr; Barbara C. Vanderhyden; Gerald M. Kidder Intercellular communication is required for ovarian folliculogenesis. This is apparent in mice lacking connexin43 (Cx43, a gap junction protein strongly expressed in granulosa cells), or growth/differentiation factor-9...
Journal Articles
J Cell Sci (2004) 117 (20): 4717–4726.
Published: 15 September 2004
... cells), derived by overexposing J774 cells to extracellular ATP until they do not display the phenomenon of ATP-induced permeabilization, are essentially uncoupled. Western-blot and reverse-transcription polymerase chain reaction assays revealed that ATP-s and ATP-i cells express connexin43 (Cx43...
Journal Articles
J Cell Sci (2004) 117 (7): 1211–1220.
Published: 01 March 2004
...Edward Leithe; Edgar Rivedal Connexins are membrane-spanning proteins that form gap junction channels between adjacent cells. Connexin43 (Cx43), the most widely expressed member of the connexin family in tissues and cell lines, has a rapid turnover rate and its degradation involves both...
Journal Articles
J Cell Sci (2004) 117 (3): 507–514.
Published: 22 January 2004
... connexin43 (Cx43). Identification of and interference with the amino acid(s) that becomes phosphorylated in response to stimulation are important steps towards defining the relationship between Cx43 phosphorylation and cell cycle. Using immunoblotting and phosphospecific antibodies we were able to show...
Journal Articles
J Cell Sci (2003) 116 (5): 875–885.
Published: 01 March 2003
... whether loss of cardiac gap junctions, such as described in cardiac disease states, may influence the expression patterns of other intercalated disc-associated proteins. We investigated whether the major cardiac gap junction protein connexin43 (Cx43) may be responsible for regulating adherens junctions...