... © 2011. 2011 Gap junction protein Connexin-43 Connexin-50 Autophagy Cellular proteins are continually renewed by synthesis and degradation. One of the fundamental cellular mechanisms involved in protein degradation is macroautophagy, a process by which cells autodigest parts...

... of gap junctions have remained largely unknown. Here, we show that ubiquitin is strongly relocalized to connexin-43 (Cx43; also known as Gja1) gap junction plaques in response to activation of protein kinase C. Cx43 remained ubiquitylated during its transition to a Triton X-100-soluble state and along...