... and tissue remodeling is challenging. To address this challenge, engineered microtissues and computational models play an increasingly large role. In this Review, we propose that Notch takes on the role of a ‘mechanostat’, maintaining the mechanical equilibrium of tissues. We discuss the reciprocal role...

.... 14 1 2020 3 7 2020 © 2020. Published by The Company of Biologists Ltd 2020 http://www.biologists.com/user-licence-1-1/ Summary: Computational modeling shows that LRP6 endocytosis in vertebrates is clathrin-independent and not restricted to lipid rafts or microdomains...

... ( [email protected] ) Competing interests The authors declare no competing or financial interests. 25 11 2014 30 3 2015 © 2015. Published by The Company of Biologists Ltd 2015 Cell polarity Budding pattern Computational modeling Saccharomyces cerevisiae GTPase...

...Amina A. Qutub; Aleksander S. Popel Hypoxia-inducible factor-1, HIF1, transcriptionally activates over 200 genes vital for cell homeostasis and angiogenesis. We developed a computational model to gain a detailed quantitative understanding of how HIF1 acts to sense oxygen and respond to hypoxia...