...) and the endogenous ligand kynurenine (Kyn), a tryptophan-derived metabolite. This approach identified a signature of six genes ( CYP1A1 , ALDH1A3 , ABCG2 , ADGRF1 and SCIN ) as commonly activated by endogenous or exogenous ligands of AHR in multiple colon cancer cell lines. Among these, the actin-severing protein...

... of transcripts in colon adenocarcinoma patient tissues led to the identification of a DNA damage responsive miR signature called DNA damage sensitive miRs (DDSMs). DDSMs were experimentally validated in the cancerous colon tissues obtained from an independent cohort of colon cancer patients and in multiple...

... inhibition, relative to apoptosis activation in HCT116 colon cancer cells expressing enhanced green fluorescent protein (EGFP) under the control of the HSP70 promoter. Single-cell and high-content time-lapse imaging of epoxomicin treatment revealed that neither basal activity nor the time of onset of the HSR...

...-A expression levels and provide new evidence for the roles of IR-B to limit proliferation of CRC cells. * Author for correspondence ( [email protected] ) 25 09 2013 © 2013. Published by The Company of Biologists Ltd 2013 Colon cancer Differentiation Insulin receptor isoform B...

... cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms. YWK-II protein/APLP2 Bat3 Stability Ubiquitin Nuclear export Apoptosis Colon cancer YWK-II protein was initially identified as the target antigen to a monoclonal...

... contributed equally to this work ‡ Author for correspondence ( [email protected] ) 26 3 2010 © 2010. 2010 Colon cancer L1 Metastasis NF-κB IκB Ezrin Studies of inherited and sporadic colorectal cancer (CRC) revealed the Wnt/β-catenin pathway ( Kinzler...

...Koji Aoki; Makoto M. Taketo The adenomatous polyposis coli ( APC ) gene is a key tumor suppressor gene. Mutations in the gene have been found not only in most colon cancers but also in some other cancers, such as those of the liver. The APC gene product is a 312 kDa protein that has multiple...

... of RER markers, a cis -Golgi resident protein, and the GalNAc α- O -Ser/Thr epitope (Tn) in human colon cancer cells and in normal colon. In cultured mucin-producing colon cancer cells, Gal-NAc α- O -Ser/Thr was found in mucin droplets and in RER cisternae. In addition, the Golgi apparatus...