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Keywords: Collagen
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Journal Articles
J Cell Sci (2022) 135 (1): jcs258879.
Published: 13 January 2022
... complex Collagen Extracellular matrix Glycosylation Proteoglycans Secretory pathway Biotechnology and Biological Sciences Research Council http://dx.doi.org/10.13039/501100000268 BB/T001984/1 University of Manchester http://dx.doi.org/10.13039/501100000770...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (18): jcs258643.
Published: 27 September 2021
... of peptide bonds. It has been shown that, upon eIF5A depletion, yeast ribosomes stall in polyproline motifs, but also in tripeptide sequences that combine proline with glycine and charged amino acids. Mammalian collagens are enriched in putative eIF5A-dependent Pro-Gly-containing tripeptides. Here, we show...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (17): jcs259075.
Published: 07 September 2021
... removal of the cell monolayer by mass spectrometry (see Data availability statement). Proteins that decreased at least 5-fold in abundance (and filtered for detection of >10 peptides) in TANGO1 L−/S− compared to WT cells in three independent repeats included collagen IV, protein-glutamine γ...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (21): jcs246793.
Published: 03 November 2020
..., which is independent of the increasing epidermal length or the developmental cycles. This long-range synchronized reorganization of subcellular structures is achieved by physical links established by extracellular collagens together with extension forces generated from epidermal cell growth. Our studies...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (1): jcs224360.
Published: 09 January 2019
... that cells can be mechanically conditioned. Owing to increased focal adhesion assembly, Inv L /E:N H cells migrated faster, which could be reduced when increasing integrin affinity with high divalent cation concentrations. Mirroring these data in human patients, we observed that collagen organization...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (7): jcs203950.
Published: 09 April 2018
... of diverse animal tissues and organs. A major ECM component are members of the collagen superfamily –comprising 28 types in vertebrates – that exist in diverse supramolecular assemblies ranging from networks to fibrils. Each assembly is characterized by a hallmark feature, a protein structure called a triple...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (18): 3473–3484.
Published: 15 September 2016
...Daniela Semeniak; Rebecca Kulawig; David Stegner; Imke Meyer; Silke Schwiebert; Hendrik Bösing; Beate Eckes; Bernhard Nieswandt; Harald Schulze ABSTRACT Collagen receptors GPVI (also known as GP6) and integrin α2β1 are highly expressed on blood platelets and megakaryocytes, their immediate...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (15): 2950–2961.
Published: 01 August 2016
...Sindhu Row; Yayu Liu; Stella Alimperti; Sandeep K. Agarwal; Stelios T. Andreadis ABSTRACT We discovered that Cadherin-11 (CDH11) regulates collagen and elastin synthesis, both affecting the mechanical properties and contractile function of animal tissues. Using a Cdh11 -null mouse model, we...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (9): 1759–1768.
Published: 01 May 2016
... of matrix receptors on the formation, and dynamic and degradative activities of invadosomes. In particular, we highlight recent findings regarding the role of type I collagen fibrils in inducing the formation of a new linear organisation of invadosomes. We will also discuss invadosome plasticity more...
Journal Articles
J Cell Sci (2016) 129 (4): 706–716.
Published: 15 February 2016
... affinity to collagen I and to collagen XII that decorates the surface of collagen I fibrils. We demonstrate here that lack of COMP–collagen interaction in the extracellular space leads to changes in collagen fibril morphology and density, resulting in altered skin biomechanical properties. Surprisingly...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (4): 653–664.
Published: 15 February 2016
...Cédric Zeltz; Donald Gullberg ABSTRACT The α1β1, α2β1, α10β1 and α11β1 integrins constitute a subset of the integrin family with affinity for GFOGER-like sequences in collagens. Integrins α1β1 and α2β1 were originally identified on a subset of activated T-cells, and have since been found...
Journal Articles
J Cell Sci (2016) 129 (4): 743–756.
Published: 15 February 2016
... 2 2015 5 1 2016 © 2016. Published by The Company of Biologists Ltd 2016 Summary: Hic-5 coordinates matrix proteolysis and migration events by enhancing complex formation between MT1-MMP and FAK to initiate sprouting responses in activated endothelial cells. Collagen...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (19): 3525–3531.
Published: 01 October 2015
...Matilde Cescon; Francesca Gattazzo; Peiwen Chen; Paolo Bonaldo ABSTRACT Collagen VI represents a remarkable extracellular matrix molecule, and in the past few years, studies of this molecule have revealed its involvement in a wide range of tissues and pathological conditions. In addition to its...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (6): 1203–1213.
Published: 15 March 2014
... collagen matrices; however, its regulation during tubulogenesis is not understood. Here, we report that degradation of collagen in polarized epithelial cells is post-translationally regulated by changing the localization of MT1-MMP from the apical to the basal surface. MT1-MMP predominantly localizes...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (21): 4974–4984.
Published: 01 November 2013
... but lacked multiple collagen-processing enzymes, including lysyl oxidase ( Lox ), a BMP2-responsive gene regulated by Smad4 and Runx2. Accordingly, the collagen matrix in Smad4 mutants was disorganized, but also hypomineralized. Primary osteoblasts from these mutants did not mineralize in vitro...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (12): 2551–2560.
Published: 15 June 2013
... for genes with large 3′ terminal exons, and the applicability of the current models to large multi-exon genes is not clear. In this Commentary, we present an overview of the current understanding of NMD and discuss how analysis of nonsense mutations in the collagen gene family has provided new mechanistic...
Journal Articles
J Cell Sci (2012) 125 (5): 1118–1128.
Published: 01 March 2012
... mice and mice carrying a chondrocyte-specific Col2a1–Cre transgene. Hsp47 conditional null mutant mice died just before or shortly after birth, and exhibited severe generalized chondrodysplasia and bone deformities with lower levels of type II and type XI collagen. Second-harmonic generation (SHG...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (14): 2453–2463.
Published: 15 July 2010
... CRMs associated with the structural muscle gene fibrillar collagen 1 ( CiFCol1 ). We use these representative examples to reconstruct how compact CRMs orchestrate the muscle developmental program from pre-localized ooplasmic determinants to differentiated larval muscle in ascidian embryos. Using...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (10): 1751–1760.
Published: 15 May 2010
... collagen lattice contraction, cell migration, focal adhesion formation, and wound contraction . Wound Repair Regen. 12 , 505 - 511 . Liang W. , McDonald P. , McManus B. , van Breemen C. , Wang X. ( 2003 ). Histamine-induced Ca(2+) signaling in human valvular...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (11): 1788–1799.
Published: 01 June 2009
...Vera L. Martins; Jashmin J. Vyas; Mei Chen; Karin Purdie; Charles A. Mein; Andrew P. South; Alan Storey; John A. McGrath; Edel A. O'Toole Type VII collagen (ColVII) is the main component of anchoring fibrils, attachment structures within the lamina densa of the basement membrane...
Includes: Multimedia, Supplementary data