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Keywords: Cohesin
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Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2023) 136 (11): jcs261265.
Published: 8 June 2023
... lipid metabolism genes. We show that in cbf11Δ cells mitotic defects have already appeared prior to anaphase, before the nuclear expansion begins. Moreover, we identify altered cohesin dynamics and centromeric chromatin structure as additional factors affecting mitotic fidelity in cells with disrupted...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2023) 136 (11): jcs261014.
Published: 8 June 2023
... cohesion establishment and mitotic cohesion dissolution have been extensively explored, the regulation of cohesin loading is still poorly understood. Here, we report that the methyltransferase NSD3 is essential for mitotic sister chromatid cohesion before mitosis entry. NSD3 interacts with the cohesin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (1): jcs259102.
Published: 10 January 2022
.... In the fission yeast, Schizosaccharomyces pombe , Rec8-containing meiotic cohesin is suggested to establish kinetochore associations by mediating cohesion of the centromere cores. However, cohesin-mediated kinetochore associations on intact chromosomes have never been demonstrated directly. In the present study...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (1): jcs247577.
Published: 8 January 2021
...Avi Matityahu; Itay Onn ABSTRACT The three-dimensional structure of chromatin is determined by the action of protein complexes of the structural maintenance of chromosome (SMC) family. Eukaryotic cells contain three SMC complexes, cohesin, condensin, and a complex of Smc5 and Smc6. Initially...
Journal Articles
Journal Articles
J Cell Sci (2019) 132 (3): jcs220491.
Published: 7 February 2019
...Robert V. Skibbens ABSTRACT Condensins and cohesins are highly conserved complexes that tether together DNA loci within a single DNA molecule to produce DNA loops. Condensin and cohesin structures, however, are different, and the DNA loops produced by each underlie distinct cell processes...
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Journal Articles
Journal Articles
J Cell Sci (2017) 130 (6): 1134–1146.
Published: 15 March 2017
...Christopher Bot; Annika Pfeiffer; Fosco Giordano; Dharani E. Manjeera; Nico P. Dantuma; Lena Ström ABSTRACT NIPBL is required to load the cohesin complex on to DNA. While the canonical role of cohesin is to couple replicated sister chromatids together until the onset of mitosis, it also promotes...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (16): 3106–3116.
Published: 15 August 2015
... that paxillin interacts with cohesin and the mediator complex, which have been shown to mediate long-range chromosomal looping. We propose that these interactions occur at the IGF2 and H19 gene cluster and are involved in the formation of loops between the IGF2 and H19 promoters and the enhancer, and thus...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (4): 717–727.
Published: 15 February 2015
... explanation for the contribution of lamins and cohesins to meiotic recombination. * Author for correspondence ( [email protected] ) Competing interests The author declares no competing or financial interests. 16 07 2014 22 12 2014 © 2015. Published by The Company...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (21): 4658–4666.
Published: 1 November 2014
... for chromatin assembly of the male pronucleus, where it acts as a histone H3.3 chaperone in complex with Hira. We report here that Yem associates with the synaptonemal complex and the cohesin complex. A genetic interaction between yem 1 (V478E) and the Spo11 homolog mei-W68 , modified a yem 1 dominant effect...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (5): 685–691.
Published: 1 March 2011
...Maria T. Ocampo-Hafalla; Frank Uhlmann Cohesin is best known as a crucial component of chromosomal stability. Composed of several essential subunits in budding yeast, cohesin forms a ring-like complex that is thought to embrace sister chromatids, thereby physically linking them until their timely...
Journal Articles
J Cell Sci (2010) 123 (5): 806–813.
Published: 1 March 2010
...Lily Hui-Ching Wang; Bernd Mayer; Olaf Stemmann; Erich A. Nigg Sister chromatid cohesion is mediated by DNA catenation and proteinaceous cohesin complexes. The recent visualization of PICH (Plk1-interacting checkpoint helicase)-coated DNA threads in anaphase cells raises new questions...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2009) 122 (15): 2686–2698.
Published: 1 August 2009
... subunit of cohesin, is a key target of separase in yeast. Is the equivalent protein also a target in mammals? We show here that separase cleaves mouse Rec8 at three positions in vitro but only when the latter is hyper-phosphorylated. Expression of a Rec8 variant (Rec8-N) that cannot be cleaved in vitro...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2009) 122 (9): 1275–1284.
Published: 1 May 2009
... clusters and at imprinted loci, and X-chromosome inactivation. Here, we review recent data acquired with state-of-the-art technologies that illuminate possible mechanisms behind the diversity of CTCF functions. CTCF interacts with numerous protein partners, including cohesin, nucleophosmin, PARP1, Yy1...
Journal Articles
J Cell Sci (2008) 121 (13): 2107–2114.
Published: 1 July 2008
...Laura A. Díaz-Martínez; Juan F. Giménez-Abián; Duncan J. Clarke Sister-chromatid cohesion is essential for accurate chromosome segregation. A key discovery towards our understanding of sister-chromatid cohesion was made 10 years ago with the identification of cohesins. Since then, cohesins have...
Journal Articles
J Cell Sci (2007) 120 (17): 3123–3137.
Published: 1 September 2007
... cohesion, although how ORD protein promotes cohesion has remained elusive. We show that SMC subunits of the cohesin complex colocalize with ORD at centromeres of ovarian germ-line cells. In addition, cohesin SMCs and ORD are visible along the length of meiotic chromosomes during pachytene and remain...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (14): 2424–2434.
Published: 15 July 2007
.... CDK11 p58 Cell cycle Mitosis Cyclin-dependent kinase Sister chromatid cohesion Cohesin Mouse Cyclin-dependent kinases (CDKs) are involved in a variety of important regulatory pathways in eukaryotic cells, including cell-cycle control, apoptosis, neuronal physiology, differentiation...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2006) 119 (24): 5057–5066.
Published: 15 December 2006
..., allowing for their segregation to opposite spindle poles. The highly conserved cohesin complex is fundamental to this process, yet its role in mitosis is not fully understood. We show that depletion of cohesin from Xenopus egg extracts impairs sister chromatid cohesion and kinetochore-microtubule...