... differentiation. * Author for correspondence ( [email protected] ) 31 05 2013 © 2013. Published by The Company of Biologists Ltd 2013 EB2 EB1 ACF7 Epithelia Microtubules Cochlea Intestinal crypt Actin filaments Microtubule reorganisation is critical for differentiation...

...Andrew Forge; Daniel J. Jagger; John J. Kelly; Ruth R. Taylor Summary A role for connexin (Cx)30 in epithelial repair following injury was examined in the organ of Corti, the sensory epithelium of the cochlea. In this tissue, lesions caused by loss of the sensory hair cells are closed...

... the stress-granule-associated protein Caprin-1 as being downregulated by Pou4f3. We demonstrated that this regulation occurs through the direct interaction of Pou4f3 with binding sites in the Caprin-1 5′ flanking sequence, and describe the expression pattern of Caprin-1 mRNA and protein in the cochlea...

...Takatoshi Karasawa; Qi Wang; Yi Fu; David M. Cohen; Peter S. Steyger The cochlea and kidney are susceptible to aminoglycoside-induced toxicity. The non-selective cation channel TRPV4 is expressed in kidney distal tubule cells, and hair cells and the stria vascularis in the inner ear. To determine...

... Cochlea Apico-basal microtubule arrays Differentiation and polarisation of epithelial cells involve a dramatic reorganisation of the microtubule cytoskeleton and centrosomal components. The centrioles migrate to the apical cell surface, the radial microtubule array is largely lost and an apico...

... claudins partition into subdomains and form a novel hybrid tight junction with adherens junction organization. Apical junctional complex Outer hair cell Reticular lamina Organ of Corti Tight-adherens junction Cochlea The capacity of cells to establish permeability barriers between...

... and neurotrophin signalling gave rise to a synergistic increase in SGN survival. Taken together, the data indicate that PKCβI activation represents a key factor for the protection of the integrity of neural elements in the cochlea. * Author for correspondence (e-mail: [email protected] ) 6...

... in compartmentalization in multicellular organisms. The cochlea includes a rather peculiar compartment filled with endolymph. This compartment is characterized by high K + concentration (∼150 mM) and a positive endocochlear potential (∼90 mV; EP), both indispensable conditions for cochlear hair cells to transduce...

... associated protein which may have a dual role as a minus-end capping and anchoring protein. 14 06 2000 09 08 2000 © 2000 by Company of Biologists 2000 Microtubule Centrosome Cochlea Epithelial cell Fig. 10. A diagrammatic representation of the distribution of ninein...

... they encounter the region where the apical SSS is forming. * Author for correspondence 21 10 1994 16 12 1994 © 1995 by Company of Biologists 1995 centrosome microtubule cochlea mouse The pericentriolar material of the centrosomal microtubule-organizing centre acts...

... ) after fixation in situ in a cochlea that had been dissected away from surrounding tissues. The portions of the organ that have been examined were all selected from the basal regions of cochleas because a graded baso-apical decrease in the number of microtubules/mature pillar cell has been reported...

... ). Intercellular junctions in the reticular lamina of the organ of Corti . J. Neurocytol . 5 , 479 – 507 . 10.1007/BF01181652 Held , H. ( 1926 ). Die Cochlea der Säuger und der Vögel, ihre Entwicklung und ihr Bau . In Handbuch der Normalen und Pathologischen Physiologie, Receptionsorgane I...

... calcium cochlea hearing loss motility outer hair cells Active mechanical processes are evident in the auditory peripheral organ, the cochlea. Since the outer hair cells can change their length when stimulated electrically, chemically or mechanically, and generate acoustic emissions from...

... to the operational configuration regarded as typical for animal tissue cells in general. * Author for correspondence 28 11 1991 19 03 1992 © 1992 by Company of Biologists 1992 microtubule centrosome cochlea mouse Pillar cells are columnar epithelial cells that contain very...