1-20 of 77
Keywords: Clathrin
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
J Cell Sci (2021) 134 (3): jcs255794.
Published: 01 February 2021
...Ellis L. Ryan; James Shelford; Teresa Massam-Wu; Richard Bayliss; Stephen J. Royle ABSTRACT A multiprotein complex containing TACC3, clathrin and other proteins has been implicated in mitotic spindle stability. To disrupt this complex in an anti-cancer context, we need to understand its composition...
Includes: Supplementary data
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2020) 133 (17): jcs239681.
Published: 01 September 2020
...Francesco Baschieri; Dahiana Le Devedec; Samuel Tettarasar; Nadia Elkhatib; Guillaume Montagnac ABSTRACT Cells experience mechanical stresses in different physiological and pathological settings. Clathrin-coated structures (CCSs) are sensitive to such perturbations in a way that often results...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (13): jcs244467.
Published: 09 July 2020
... a role for clathrin and/or endocytosis in the regulation of this pathway, but conflicting results exist and demand a deeper mechanistic understanding. We investigated the consequences of clathrin depletion on Wnt/β-catenin signaling in cell lines and found a pronounced reduction in β-catenin protein...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (11): jcs240861.
Published: 04 June 2020
...Francesco Baschieri; Kseniia Porshneva; Guillaume Montagnac ABSTRACT Clathrin-mediated endocytosis is the main entry route for most cell surface receptors and their ligands. It is regulated by clathrin-coated structures that are endowed with the ability to cluster receptors and to locally bend...
Journal Articles
J Cell Sci (2019) 132 (20): jcs222992.
Published: 21 October 2019
... poster, we summarize what is known about the five AP complexes and discuss how this helps to explain the clinical features of the different genetic disorders. Five AP complexes have been identified. The first to be discovered were AP-1 and AP-2, which are abundant components of clathrin-coated...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (16): jcs232868.
Published: 15 August 2019
..., that has been acquired in opisthokonts and missing in other organisms. We discuss how other multicellular organisms, such as plants, recognise ubiquitylated cargoes. Endocytosis Endosomal transport ESCRT Ubiquitin-binding domains Clathrin Plasma membrane-localised proteins, including...
Journal Articles
J Cell Sci (2019) 132 (10): jcs224030.
Published: 15 May 2019
...Oxana M. Tsygankova; James H. Keen ABSTRACT Clathrin heavy chain is the structural component of the clathrin triskelion, but unique functions for the two distinct and highly conserved clathrin light chains (CLCa and CLCb, also known as CLTA and CLTB, respectively) have been elusive. Here, we show...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (21): jcs221317.
Published: 05 November 2018
... matrix adhesion. The vitronectin-binding integrin αVβ5 localizes to focal adhesions (FAs) as well as poorly characterized flat clathrin lattices (FCLs). Here, we show that, in human keratinocytes, αVβ5 is predominantly found in FCLs, and formation of the αVβ5-containing FCLs requires the presence...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (17): jcs216812.
Published: 03 September 2018
...Volker Haucke; Michael M. Kozlov ABSTRACT Clathrin-mediated endocytosis is an essential cellular mechanism by which all eukaryotic cells regulate their plasma membrane composition to control processes ranging from cell signaling to adhesion, migration and morphogenesis. The formation of endocytic...
Journal Articles
J Cell Sci (2018) 131 (1): jcs207696.
Published: 04 January 2018
...Wataru Yamamoto; Suguru Wada; Makoto Nagano; Kaito Aoshima; Daria Elisabeth Siekhaus; Junko Y. Toshima; Jiro Toshima ABSTRACT Clathrin-mediated endocytosis requires the coordinated assembly of various endocytic proteins and lipids at the plasma membrane. Accumulating evidence demonstrates a crucial...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2017) 130 (15): 2591–2605.
Published: 01 August 2017
..., live-cell imaging and correlative spinning-disk microscopy and transmission electron microscopy assays we provide the first in-depth high-resolution characterisation of this process. We provide a model of compensatory endocytosis based on rapid clathrin- and dynamin-mediated retrieval. Inhibition...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (8): 1379–1392.
Published: 15 April 2017
...Paul T. Manna; Samson O. Obado; Cordula Boehm; Catarina Gadelha; Andrej Sali; Brian T. Chait; Michael P. Rout; Mark C. Field ABSTRACT Clathrin-mediated endocytosis (CME) is the most evolutionarily ancient endocytic mechanism known, and in many lineages the sole mechanism for internalisation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (13): 2625–2637.
Published: 01 July 2016
... pathway that directly returns cargo from early endosomes to the cell surface. In contrast, NECAP2 does not regulate the clathrin-mediated endocytosis of these cargos, the degradation of EGFR or the recycling of transferrin along the slow, Rab11-dependent recycling pathway. We show that protein knockdown...
Journal Articles
J Cell Sci (2015) 128 (24): 4588–4600.
Published: 15 December 2015
..., constituents of Glut4 storage vesicles (GSVs). We further found that CD2AP forms a complex with GGA2, a clathrin adaptor, which sorts Glut4 to GSVs, suggesting a role for CD2AP in this process. We also found that CD2AP forms a complex with clathrin and connects clathrin to actin in the perinuclear region...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (24): 4629–4641.
Published: 15 December 2015
... endocytosis of adhesion proteins has been shown to play a role in cell migration, we examined whether Cad11 endocytosis plays a role in Cad11-mediated migration. The mechanism by which Cad11 is internalized is unknown. Using a GST pulldown assay, we found that clathrin binds to the Cad11 cytoplasmic domain...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (20): 3811–3821.
Published: 15 October 2015
...Bum-Chan Park; Yang-In Yim; Xiaohong Zhao; Maciej B. Olszewski; Evan Eisenberg; Lois E. Greene ABSTRACT Cyclin-G-associated kinase (GAK), the ubiquitously expressed J-domain protein, is essential for the chaperoning and uncoating of clathrin that is mediated by Hsc70 (also known as HSPA8). Adjacent...
Journal Articles
J Cell Sci (2015) 128 (16): 3131–3142.
Published: 15 August 2015
... are important sorting stations for some retrograde cargo. SMAP2, a GTPase-activating protein (GAP) for Arf1 with a putative clathrin-binding domain, has previously been shown to participate in the retrograde transport of the cholera toxin B-subunit (CTxB) from recycling endosomes. Here, we found that clathrin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (18): 3916–3927.
Published: 15 September 2014
...-density lipoprotein (LDL) receptor-related protein-1 (LRP1) cargo and resistance to toxins. Colocalization studies and proteomic analyses suggest that GPR107 associates with clathrin and the retromer protein VPS35 and that GPR107 might be responsible for the return of receptors to the plasma membrane from...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2014) 127 (16): 3477–3487.
Published: 15 August 2014
... to the monomeric clathrin-adaptor protein GGA2 ( Nielsen et al., 2001 ). Like AP-1, GGA2 binds to the TGN and to endosomes, and both are essential for development ( Govero et al., 2012 ; Meyer et al., 2000 ; Zizioli et al., 2010 ; Zizioli et al., 1999 ). Both receptors contain canonical YxxØ-type and dileucine...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (14): 3131–3140.
Published: 15 July 2014
... the intracellular localization of M1-mAChR. In this study, we observed constitutive internalization of M1-mAChR in mouse neuroblastoma N1E-115 cells without agonist stimulation. Constitutive internalization depended on dynamin, clathrin and the adaptor protein-2 (AP-2) complex. A WxxI motif in the M1-mAChR C...
Includes: Supplementary data