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Keywords: Ciz1
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Journal Articles
J Cell Sci (2015) 128 (8): 1518–1527.
Published: 15 April 2015
...Nikki A. Copeland; Heather E. Sercombe; Rosemary H. C. Wilson; Dawn Coverley CIZ1 is a nuclear matrix protein that cooperates with cyclin A2 (encoded by CCNA2 ) and CDK2 to promote mammalian DNA replication. We show here that cyclin‐A–CDK2 also negatively regulates CIZ1 activity by phosphorylation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (10): 2466–2477.
Published: 15 May 2012
...Erin A. Greaves; Nikki A. Copeland; Dawn Coverley; Justin F. X. Ainscough CIZ1 is a nuclear-matrix-associated DNA replication factor unique to higher eukaryotes, for which alternatively spliced isoforms have been associated with a range of disorders. In vitro, the CIZ1 N-terminus interacts...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (7): 1108–1115.
Published: 01 April 2010
...-replication complex assembly, whereas cyclin-A-associated kinase acts later to terminate assembly and activate DNA replication. The mechanism by which these events are coordinated is unknown. Here, we show that the replication factor Ciz1 interacts with cyclins E and A sequentially through distinct cyclin...
Journal Articles
J Cell Sci (2007) 120 (1): 115–124.
Published: 01 January 2007
...Justin F.-X. Ainscough; Faisal Abdel Rahman; Heather Sercombe; Alicia Sedo; Bjorn Gerlach; Dawn Coverley Cip1-interacting zinc finger protein 1 (Ciz1) stimulates DNA replication in vitro and is required for mammalian cells to enter S phase. Here, we show that a significant proportion of Ciz1...
Journal Articles
J Cell Sci (2005) 118 (1): 101–112.
Published: 01 January 2005
...Dawn Coverley; Jackie Marr; Justin Ainscough Using a cell-free system that reconstitutes initiation of mammalian DNA replication, we identified a cyclin A-responsive protein, p21 Cip1 -interacting zinc finger protein 1 (Ciz1). In cell-free experiments, Ciz1 protein increases the number of nuclei...
Includes: Supplementary data