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Keywords: Cilia
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Journal Articles
In collection:
Cilia and flagella
J Cell Sci (2024) 137 (10): jcs261692.
Published: 3 June 2024
... Ciliogenesis Trypanosoma Cilia Flagella Nigel Groome PhD studentship Wellcome Trust http://dx.doi.org/10.13039/100010269 211075/Z/18/Z Oxford Brookes University http://dx.doi.org/10.13039/100010053 Cilia and flagella are highly conserved microtubule-based...
Includes: Supplementary data
Journal Articles
J Cell Sci (2024) 137 (8): jcs261816.
Published: 1 May 2024
...Johannes F. Weijman; Laura Vuolo; Caroline Shak; Anna Pugnetti; Aakash G. Mukhopadhyay; Lorna R. Hodgson; Kate J. Heesom; Anthony J. Roberts; David J. Stephens ABSTRACT Primary cilia are essential eukaryotic organelles required for signalling and secretion. Dynein-2 is a microtubule-motor protein...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and flagella
J Cell Sci (2024) 137 (1): jcs261497.
Published: 12 January 2024
...Poulomi Das; Betlehem Mekonnen; Rama Alkhofash; Abha V. Ingle; E. Blair Workman; Alec Feather; Gui Zhang; Nathan Chasen; Peiwei Liu; Karl F. Lechtreck ABSTRACT In Chlamydomonas , the channel polycystin 2 (PKD2) is primarily present in the distal region of cilia, where it is attached to the axoneme...
Includes: Supplementary data
Journal Articles
J Cell Sci (2023) 136 (23): jcs261387.
Published: 1 December 2023
... to separate genetic material equally into two daughter cells. In non-dividing cells, the mother centriole, a substructure of the centrosome, matures into a basal body and nucleates cilia, which acts as a signal-transducing antenna. The functions of centrosomes and their substructures are important...
Journal Articles
J Cell Sci (2024) 137 (5): jcs261047.
Published: 4 September 2023
...Huxley K. Hoffman; Rytis Prekeris ABSTRACT Primary cilia are sensory cellular organelles crucial for organ development and homeostasis. Ciliogenesis in polarized epithelial cells requires Rab19-mediated clearing of apical cortical actin to allow the cilium to grow from the apically docked basal...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and flagella
J Cell Sci (2023) 136 (16): jcs260807.
Published: 29 August 2023
...Riley A. Cooney; Maxwell L. Saal; Kara P. Geraci; Caitlin Maynard; Ondine Cleaver; Oanh N. Hoang; Todd T. Moore; Rosa F. Hwang; Jeffrey D. Axelrod; Eszter K. Vladar ABSTRACT Multiciliated cells contain hundreds of cilia whose directional movement powers the mucociliary clearance of the airways...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and flagella
J Cell Sci (2023) 136 (16): jcs261070.
Published: 17 August 2023
...Tomohiro Kubo; Yuma Tani; Haru-Aki Yanagisawa; Masahide Kikkawa; Toshiyuki Oda ABSTRACT α- and β-tubulin have an unstructured glutamate-rich region at their C-terminal tails (CTTs). The function of this region in cilia and flagella is still unclear, except that glutamates in CTTs act as the sites...
Includes: Supplementary data
Journal Articles
J Cell Sci (2023) 136 (8): jcs260353.
Published: 24 April 2023
... discovery that calcineurin directly associates with centriolar proteins highlights a role for Ca 2+ and calcineurin signaling at these organelles. Calcineurin inhibition promotes elongation of primary cilia without affecting ciliogenesis. Thus, Ca 2+ signaling within cilia includes previously unknown...
Includes: Supplementary data
Journal Articles
J Cell Sci (2023) 136 (3): jcs260565.
Published: 8 February 2023
...Peiwei Liu; Ying Liu; Jun Zhou ABSTRACT Cilia are surface-exposed organelles that provide motility and sensory functions for cells, and it is widely believed that mechanosensation can be mediated through cilia. Polycystin-1 and -2 (PC-1 and PC-2, respectively) are transmembrane proteins that can...
Journal Articles
Journal Articles
In collection:
Cilia and flagella
J Cell Sci (2022) 135 (24): jcs260303.
Published: 19 December 2022
...Chun-Xue Song; Xian-Ting Zeng; Wan-Xin Zeng; Rong Liu; Xia-Jing Tong; Qian Li ABSTRACT Cilia are conserved organelles found in many cell types in eukaryotes, and their dysfunction causes defects in environmental sensing and signaling transduction; such defects are termed ciliopathies. Distinct...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and flagella
J Cell Sci (2022) 135 (24): jcs260408.
Published: 19 December 2022
...Karl Lechtreck ABSTRACT The assembly and maintenance of most cilia and eukaryotic flagella depends on intraflagellar transport (IFT), the bidirectional movement of multi-megadalton IFT trains along the axonemal microtubules. These IFT trains function as carriers, moving ciliary proteins between...
Journal Articles
J Cell Sci (2023) 136 (5): jcs260073.
Published: 7 November 2022
... and anterograde transport, respectively, in the cilium. WDR34 (also known as DYNC2I2), a dynein-2 intermediate chain, is required for the maintenance of cilia function. Here, we investigated WDR34 mutations identified in Jeune syndrome, short-rib polydactyly syndrome and asphyxiating thoracic dysplasia patients...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (19): jcs246553.
Published: 12 October 2022
...Irene Ojeda Naharros; Maxence V. Nachury ABSTRACT Cilia sense and transduce sensory stimuli, homeostatic cues and developmental signals by orchestrating signaling reactions. Extracellular vesicles (EVs) that bud from the ciliary membrane have well-studied roles in the disposal of excess ciliary...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2022) 135 (16): jcs260299.
Published: 22 August 2022
...Bo Lv; Xiao-Ou Zhang; Gregory J. Pazour ABSTRACT During Hedgehog signaling, the ciliary levels of Ptch1 and Smo are regulated by the pathway. At the basal state, Ptch1 localizes to cilia and prevents the ciliary accumulation and activation of Smo. Upon binding a Hedgehog ligand, Ptch1 exits cilia...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and flagella
J Cell Sci (2023) 136 (5): jcs259535.
Published: 22 June 2022
...Mia J. Konjikusic; Chanjae Lee; Yang Yue; Bikram D. Shrestha; Ange M. Nguimtsop; Amjad Horani; Steven Brody; Vivek N. Prakash; Ryan S. Gray; Kristen J. Verhey; John B. Wallingford ABSTRACT Most motile cilia have a stereotyped structure of nine microtubule outer doublets and a single central pair...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and flagella
J Cell Sci (2023) 136 (5): jcs259257.
Published: 17 May 2022
...Alice Dupont Juhl; Zeinab Anvarian; Stefanie Kuhns; Julia Berges; Jens S. Andersen; Daniel Wüstner; Lotte B. Pedersen ABSTRACT Primary cilia are microtubule-based sensory organelles whose assembly and function rely on the conserved bidirectional intraflagellar transport (IFT) system, which...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (10): jcs259030.
Published: 16 May 2022
...Huxley K. Hoffman; Rytis Prekeris ABSTRACT Primary cilia play a key role in the ability of cells to respond to extracellular stimuli, such as signaling molecules and environmental cues. These sensory organelles are crucial to the development of many organ systems, and defects in primary...
Journal Articles