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Keywords: Cilia
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Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2023) 136 (5): jcs259535.
Published: 22 June 2022
...Mia J. Konjikusic; Chanjae Lee; Yang Yue; Bikram D. Shrestha; Ange M. Nguimtsop; Amjad Horani; Steven Brody; Vivek N. Prakash; Ryan S. Gray; Kristen J. Verhey; John B. Wallingford ABSTRACT Most motile cilia have a stereotyped structure of nine microtubule outer doublets and a single central pair...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2023) 136 (5): jcs259257.
Published: 17 May 2022
...Alice Dupont Juhl; Zeinab Anvarian; Stefanie Kuhns; Julia Berges; Jens S. Andersen; Daniel Wüstner; Lotte B. Pedersen ABSTRACT Primary cilia are microtubule-based sensory organelles whose assembly and function rely on the conserved bidirectional intraflagellar transport (IFT) system, which...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (10): jcs259030.
Published: 16 May 2022
...Huxley K. Hoffman; Rytis Prekeris ABSTRACT Primary cilia play a key role in the ability of cells to respond to extracellular stimuli, such as signaling molecules and environmental cues. These sensory organelles are crucial to the development of many organ systems, and defects in primary...
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2022) 135 (6): jcs259201.
Published: 16 March 2022
...Kotoku Kawaguchi; Shogo Nakayama; Daichi Saito; Haruka Kogiso; Kasane Yasuoka; Yoshinori Marunaka; Takashi Nakahari; Shinji Asano ABSTRACT Mucociliary clearance, which is conducted by beating cilia cooperating with the surface mucous layer, is a major host defense mechanism of the airway epithelium...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2021) 134 (18): jcs259010.
Published: 23 September 2021
... directly into retrograde trains. Cilia Dynein1b Kinesin-2 BBSome Flagella National Institutes of Health http://dx.doi.org/10.13039/100000002 R01GM110413 References Backer , M. V. , Levashova , Z. , Patel , V. , Jehning , B. T. , Claffey , K...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2021) 134 (16): jcs258544.
Published: 18 August 2021
... function. Centrosome Cilia Cytoskeleton Mechanobiology Organelle assembly Rootlets Medical Research Council http://dx.doi.org/10.13039/501100007155 University of Cambridge http://dx.doi.org/10.13039/501100000735 Isaac Newton Trust http://dx.doi.org/10.13039...
Journal Articles
In collection:
Cilia and Flagella
Series: SUBJECT COLLECTION: CILIA AND FLAGELLA
J Cell Sci (2021) 134 (15): jcs258626.
Published: 3 August 2021
...Stephen M. King ABSTRACT Axonemal dyneins power the beating of motile cilia and flagella. These massive multimeric motor complexes are assembled in the cytoplasm, and subsequently trafficked to cilia and incorporated into the axonemal superstructure. Numerous cytoplasmic factors are required...
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2021) 134 (12): jcs247163.
Published: 14 June 2021
... Summary: A discussion of the current structural understanding of the intraflagellar transport (IFT) and of how IFT trains function as macromolecular machines to assemble the structure of the cilium. IFT Cilia Dynein Kinesin Protein structure Transport Cilia are highly ordered...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2021) 134 (6): jcs254995.
Published: 26 March 2021
.../jbc.M302536200 Loktev , A. V. and Jackson , P. K. ( 2013 ). Neuropeptide Y family receptors traffic via the Bardet-Biedl syndrome pathway to signal in neuronal primary cilia . Cell Rep. 5 , 1316 - 1329 . 10.1016/j.celrep.2013.11.011 Malicki , J. and Avidor-Reiss , T...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2020) 133 (18): jcs248989.
Published: 23 September 2020
...Eloïse Bertiaux; Adeline Mallet; Brice Rotureau; Philippe Bastin ABSTRACT Multicellular organisms assemble cilia and flagella of precise lengths differing from one cell to another, yet little is known about the mechanisms governing these differences. Similarly, protists assemble flagella...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2020) 133 (17): jcs249805.
Published: 11 September 2020
... by ∼90% in control cells and essentially abolished when the tubulin-binding site of IFT81 was incapacitated. Despite the strong reduction in IFT, the proportion of E-hook-deficient GFP–β-tubulin in the axoneme was only moderately reduced. In vivo imaging showed more GFP–β-tubulin particles entering cilia...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2020) 133 (16): jcs245233.
Published: 21 August 2020
...Emiliya Poghosyan; Ioan Iacovache; Lenka Faltova; Alexander Leitner; Pinfen Yang; Dennis R. Diener; Ruedi Aebersold; Benoit Zuber; Takashi Ishikawa ABSTRACT The radial spoke is a key element in a transducer apparatus controlling the motility of eukaryotic cilia. The transduction biomechanics...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2020) 133 (12): jcs240648.
Published: 28 June 2020
... embryos or embryos expressing C-terminally modified forms of Epb41l5 developed cilia with reduced motility and exhibited left–right patterning defects, an outcome of abnormal ciliary function. We observed genetic synergy between epb41l5 and iqcb1. Moreover, EPB41L5 decreased IQCB1 interaction with CEP290...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2020) 133 (12): jcs243592.
Published: 24 June 2020
... leads to cilia loss, RGP mislocalization, junctional integrity disruption, massive heterotopia and severe cerebellar hypoplasia. Together, these findings indicate that complete CPAP loss leads to severe and complex phenotypes in developing mouse brain, and provide new insights into the causes of MCPH...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (6): jcs240614.
Published: 30 March 2020
...Laura Vuolo; Nicola L. Stevenson; Aakash G. Mukhopadhyay; Anthony J. Roberts; David J. Stephens ABSTRACT Cytoplasmic dynein-2 is a motor protein complex that drives the movement of cargoes along microtubules within cilia, facilitating the assembly of these organelles on the surface of nearly all...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (2): jcs239855.
Published: 23 January 2020
... . Leishmania Cilia Dynein Flagella Motility * Author for correspondence ( eva.gluenz@path.ox.ac.uk ) Competing interests The authors declare no competing or financial interests. Fig. 4. LAX28 is required for flagellar localization of IC140 and CFAP44. Fluorescence micrographs...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2020) 133 (1): jcs239566.
Published: 2 January 2020
... and other cellular processes. Centriolar satellites Centrosome Cilia Ciliopathies Proteostasis The centrosome is composed of a pair of centrioles surrounded by pericentriolar material (PCM) and serves as the primary microtubule-organizing centre (MTOC) in animal cells. Centriolar...
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2019) 132 (22): jcs233973.
Published: 14 November 2019
..., and MICAL-L1 localizes to cilia and centrosomes in both ciliated and non-ciliated cells. Consistent with EHD1 function, MICAL-L1-depletion prevents CP110 removal from the mother centriole. Moreover, upon MICAL-L1-depletion, EHD1 fails to localize to basal bodies. Since MICAL-L1 localizes to the centrosome...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (17): jcs230680.
Published: 4 September 2019
...) protein Ahi1 in mouse embryonic fibroblasts (MEFs) has a small effect on cilia formation. However, Ahi1 loss in these cells results in: (1) reduced localization of the JBTS-associated protein Arl13b to the ciliary membrane, (2) decreased sonic hedgehog signaling, (3) and an abnormally elongated ciliary...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2019) 132 (16): jcs233429.
Published: 19 August 2019
... Bloodgood , R. A. ( 1980 ). Direct visualization of dynamic membrane events in cilia . J. Exptl. Zool.   213 , 293 - 295 . 10.1002/jez.1402130218 Bloodgood , R. A. ( 1981 ). Flagella-dependent gliding motility in Chlamydomonas . Protoplasma   106 , 183 - 192 . 10.1007/BF01275550...
Includes: Supplementary data